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Gene activity in human cortex shows striking sex differences
The results mark a "dramatic shift" in how neuroscientists think about sex differences, and they may help explain sex biases in certain neurodegenerative and neurodevelopmental conditions.
What leeches reveal about movement
Lidia Szczupak turned to the animals to explore how the nervous system coordinates movement.
Switching neural code may solve ongoing face-recognition debate
Face patch cells in macaque monkeys initially respond to images of any object but rapidly transition to attend to faces exclusively, a new study finds.
Frameshift: How Mia Thomaidou tapped a fellowship to connect neuroscience to criminal justice
As a fellow at the Dana Foundation, she merged two familiar passions and discovered a new one: science philanthropy.
To understand decision-making, we need to truly challenge lab animals
Complex, multidimensional tasks that unfold over time could reveal how different brain areas work together to support decisions.
Nearly 400 compounds affect behaviors tied to autism-linked genes in zebrafish
Estropipate, paclitaxel and levocarnitine altered behaviors tied to SCN2A and DYRK1A variants specifically, a new open-source platform revealed.
Arousal neurons' activity explains brain's blood flow dynamics in mice
The findings could influence how researchers interpret signals from techniques that use blood flow as a surrogate for neuronal activity.
This paper changed my life: Erin Calipari ponders the nuances of rewarding and aversive stimuli
A 1960s study by Kelleher and Morse found that lever pressing in squirrel monkeys depended not on whether they received a reward or shock, but on the rules of the task. This taught Calipari to think deeply about factors that influence how b
Why neural foundation models work, and what they might-and might not-teach us about the brain
These models can partly generalize across species, brain regions and tasks, suggesting that a set of machine-learnable rules govern neural population activity. But will we be able to understand them?
Error equation predicts brain's ability to generalize
Four statistical measurements of neural network geometry capture how well brains and artificial networks use what they already know to solve new problems, a study suggests.
Embrace complexity to improve the translatability of basic neuroscience
Researchers must learn to view heterogeneity as an essential feature of the systems they study and a central consideration in experimental design, not a variable to control for or reduce.
What geckos tell us about the evolution of hearing
Catherine Carr explains her discovery that geckos retain a vibration-sensing pathway previously thought to be lost when animals moved onto land.
Frameshift: How Caitlin Vander Weele made science communication her business
Her favorite part of research was talking about it. So she left academia and turned that passion into a successful company.
Signs of aging vary across brain cells
Senescence presents differently depending on the cell type, toxic trigger and neighboring cells, two new studies find.
Neuroscientists challenge NIH's proposed human-data access policy
The changes would restrict the sharing of human neuroimaging, transcriptomic and genetic data.
Large-scale neuroimaging datasets often lack information specific to women's health, constraining AI's analysis potential
Addressing this gap will require collecting widespread data on pregnancy, menopause and other life events women experience-and could bring us closer to the "holy grail" of linking brain and behavior.
Remembering Annette Dolphin, who helped explain gabapentin's effects
The "intuitive" neuropharmacologist pushed against the status quo.
Revised statistical bar extracts less-common variants from autism genetics studies
Adjusting genetic analyses could help plug autism's heritability gap, according to a new preprint.
This paper changed my life: Talia Lerner reflects on dopamine neuron diversity and the value of simple experiments
In a 2011 Neuron study, Stephan Lammel and his colleagues showed that dopamine neurons with different projections have different physiological properties. The work inspired Lerner to think about how to challenge widely held assumptions in t
Hippocampus builds reputation as 'general-purpose statistical learning machine'
New cross-species findings may help settle a long-standing debate about whether the hippocampus is required for passive learning.
Securing the academic pipeline amid uncertain U.S. funding climate
Finding creative ways to keep early-career researchers in academia-for example, through part-time roles-can help the field weather the storm.
Shifting neural code powers speech comprehension
Dynamic coding helps explain how the brain processes multiple features of speech-from the smallest units of sounds to full sentences-simultaneously.
Astrocytes orchestrate oxytocin's social effects in mice
The cells amplify oxytocin-and may be responsible for sex differences in social behavior, two preprints find.
Neuro's ark: Spying on the secret sensory world of ticks
Carola Städele, a self-proclaimed "tick magnet," studies the arachnids' sensory neurobiology-in other words, how these tiny parasites zero in on their next meal.
Lack of reviewers threatens robustness of neuroscience literature
Simple math suggests that small groups of scientists can significantly bias peer review.
Post-infection immune conflict alters fetal development in some male mice
The immune-conflict between dam and fetus could help explain sex differences in neurodevelopmental conditions.
Is there a neuroscientist in the House?
Sam Wang, a neuroscientist running for the U.S. House of Representatives, has been considering American democracy for decades.
Infant visual system categorizes common objects by 2 months of age
Brain activity patterns in the ventral visual cortex appear to distinguish images across 12 categories, including birds and trees, longitudinal functional MRI scans suggest.
Frameshift: Raphe Bernier followed his heart out of academia, then made his way back again
After a clinical research career, an interlude at Apple and four months in early retirement, Raphe Bernier found joy in teaching.
Organoid study reveals shared brain pathways across autism-linked variants
The genetic variants initially affect brain development in unique ways, but over time they converge on common molecular pathways.
