Giredestrant-everolimus nearly doubles PFS in ESR1-mutant BC

Editor's Pick: Giredestrant plus Everolimus in Advanced Breast Cancer (New England Journal of Medicine, 2026)
This AudioScholar briefing is generated by artificial intelligence for healthcare professionals and trainees. It is not medical advice.
Welcome to This Week in Oncology. This week we're covering 10 notable papers spanning new ways to overcome treatment resistance in breast and pancreatic cancer, the growing role of immunotherapy before surgery and transplant, advances in hematologic malignancies, and supportive care and prevention trials that test what actually helps patients. Let's dive in.
This week's papers:
• Giredestrant plus Everolimus in Advanced Breast Cancer. — New England Journal of Medicine 2026 (pubmed.ncbi.nlm.nih.gov/42814929)
• Pancreatic Cancer KRAS Breakthrough: Drug Graveyard No More. — Clinical Cancer Research 2026 (pubmed.ncbi.nlm.nih.gov/42836735)
• Intravenous hyaluronidase-expressing oncolytic adenovirus with chemotherapy in metastatic pancreatic cancer: a randomized phase 2b trial. — Nature Medicine 2026 (pubmed.ncbi.nlm.nih.gov/42816596)
• Five-year survival with neoadjuvant therapy in melanoma: updated pooled analysis from the International Neoadjuvant Melanoma Consortium (INMC). — Nature Medicine 2026 (pubmed.ncbi.nlm.nih.gov/42823486)
• Immune Checkpoint Inhibitor-Based Downstaging Therapy for Hepatocellular Carcinoma. — JAMA Oncology 2026 (pubmed.ncbi.nlm.nih.gov/42821267)
• FDA Approval Summary: Epcoritamab with Lenalidomide and Rituximab for Relapsed or Refractory Follicular Lymphoma. — Clinical Cancer Research 2026 (pubmed.ncbi.nlm.nih.gov/42820870)
• Sitagliptin for Acute Graft-Versus-Host Disease Prevention in Alternative Donor Transplantation: A Randomized Phase III Trial. — Journal of Clinical Oncology 2026 (pubmed.ncbi.nlm.nih.gov/42837636)
• Treatment of Multiple Myeloma: ASCO Living Guideline, Version 2026.1.3. — Journal of Clinical Oncology 2026 (pubmed.ncbi.nlm.nih.gov/42814948)
• Smoking Cessation Among Underserved Patients Referred for Lung Cancer Screening: A Randomized Clinical Trial. — JAMA 2026 (pubmed.ncbi.nlm.nih.gov/42832220)
• Efficacy of Cryotherapy in Preventing Taxane-Induced Neuropathy: The CryoPac Randomised Controlled Trial. — Annals of Oncology 2026 (pubmed.ncbi.nlm.nih.gov/42838271)
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