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Editor's Pick: Dexamethasone-Free Antiemetic Prophylaxis for Children and Adolescents Receiving Highly Emetogenic Chemotherapy: A Multicenter, Phase III, Noninferiority Trial (CIVIC POD) (Journal of Clinical Oncology, 2026)
Welcome to This Week in Oncology. This week we're covering 7 notable papers spanning supportive care and de-escalation, biomarker-driven treatment selection across solid tumours, and rare cancers with long-term outcome data. Let's dive in.

We start with two trials that ask whether adding or removing a drug actually changes anything.
This week's papers:
• Dexamethasone-Free Antiemetic Prophylaxis for Children and Adolescents Receiving Highly Emetogenic Chemotherapy: A Multicenter, Phase III, Noninferiority Trial (CIVIC POD) — Journal of Clinical Oncology 2026 (pubmed.ncbi.nlm.nih.gov/42535876)
• Addition of High-Dose Vitamin D3 to Standard Treatment in Patients With Metastatic Colorectal Cancer: The SOLARIS Randomized Clinical Trial (Alliance A021703) — JAMA 2026 (pubmed.ncbi.nlm.nih.gov/42545685)
• Impact of Tumor Genomic Profile on Adjuvant Chemotherapy Efficacy in Resected Pancreatic Adenocarcinoma: Results From the PRODIGE-24/CCTG PA6 Study — Journal of Clinical Oncology 2026 (pubmed.ncbi.nlm.nih.gov/42546248)
• Long-Term Analysis of Patients With Ewing Sarcoma Included in the Euro-EWING99 Study — Journal of Clinical Oncology 2026 (pubmed.ncbi.nlm.nih.gov/42537000)
• Darolutamide Alone and in Combination With Goserelin in Androgen Receptor-Positive Salivary Gland Carcinoma: Results From the Phase II DISCOVARY Trial — Journal of Clinical Oncology 2026 (pubmed.ncbi.nlm.nih.gov/42546251)
• High-Risk Smoldering Multiple Myeloma: A Review of Controversies in Early Treatment Versus Observation — Journal of Clinical Oncology 2026 (pubmed.ncbi.nlm.nih.gov/42535861)
• Circulating thymidine kinase activity predicts survival and optimal treatment sequencing in BRAF-mutated metastatic melanoma in the SECOMBIT trial — Clinical Cancer Research 2026 (pubmed.ncbi.nlm.nih.gov/42550831)
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