This Week in Oncology — Jun 6, 2026

Welcome to This Week in Oncology. This week we're covering 10 notable papers spanning major updates in lung cancer, novel therapeutic strategies for tough-to-treat malignancies, and new insights into tumor biology and supportive care. Let's dive in.

We begin this week with lung cancer, where a long-term follow-up from the ASTRUM-005 trial was published in JAMA Oncology [6].
This week's papers:
• Intrathecal nivolumab in metastatic solid tumors with leptomeningeal disease: dose escalation part of the multicenter IT-PD1/NOA-26 phase 1 trial. — Nature Cancer 2026 (pubmed.ncbi.nlm.nih.gov/42243276)
• Hypoxia shapes both therapeutic response and resistance in metastatic clear cell renal cell carcinoma. — Cancer Cell 2026 (pubmed.ncbi.nlm.nih.gov/42242232)
• Plasma signals of lung tumor promotion for molecular cancer prevention. — Cell 2026 (pubmed.ncbi.nlm.nih.gov/42242224)
• Guanylyl Cyclase 2C-Targeted Chimeric Antigen Receptor T-Cell Therapy in Patients With Metastatic Colorectal Cancer. — Journal of Clinical Oncology 2026 (pubmed.ncbi.nlm.nih.gov/42241671)
• Reducing or omitting dexamethasone with NEPA and olanzapine for prevention of chemotherapy-induced nausea and vomiting in highly emetogenic chemotherapy: a randomized non-inferiority phase III trial. — Journal of Clinical Oncology 2026 (pubmed.ncbi.nlm.nih.gov/42241642)
• First-Line Serplulimab in Extensive-Stage Small Cell Lung Cancer: Secondary Analysis of the ASTRUM-005 Phase 3 Randomized Clinical Trial. — JAMA Oncology 2026 (pubmed.ncbi.nlm.nih.gov/42240984)
• Spermine is an endogenous iron chelator that inhibits ferroptosis. — Nature 2026 (pubmed.ncbi.nlm.nih.gov/42236947)
• Acquired genetic and cell-state changes in IDH-mutant glioma progression. — Nature 2026 (pubmed.ncbi.nlm.nih.gov/42236943)
• All-Oral Treatment of Newly Diagnosed Acute Myeloid Leukemia. — The New England Journal of Medicine 2026 (pubmed.ncbi.nlm.nih.gov/42235013)
• Obexelimab for the Treatment of IgG4-Related Disease. — The New England Journal of Medicine 2026 (pubmed.ncbi.nlm.nih.gov/42233621)
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