#169 MGUS to Multiple Myeloma Diagnostics and Counseling: 5 Pearls Segment

<p>SPEP vs. UPEP? What does it tell you and not tell you? What is the role for immunofixation and free light chains in diagnosis? Learn about paraneoplastic antibodies with MGCS and its renal, neurologic, and dermatologic manifestations!</p><p><strong>Sponsor</strong>: <a href="coreimpodcast.com/Freed"; rel="nofollow">Freed</a> is an AI scribe that listens and writes your note in < 30 seconds. Freed <strong>learns your style</strong> over time and is HIPAA compliant! </p><p>Use the code <strong>CORE50</strong> to get 50% off your first month with <a href="coreimpodcast.com/Freed"; rel="nofollow">Freed</a></p><p>🔹 <strong>This episode is also sponsored by Factor!</strong> Get fresh, ready-made meals delivered to your door. Use the code <strong>factorpodcast</strong> for a special discount at <a href="factor75.com/"; rel="nofollow">factor75.com</a>.</p><p><a href="youtube.com/playlist?list=PLD6maWB-VZPDYXYDVSB…; rel="nofollow"><strong>Behind The Scenes Youtube Interview with Dr. Vincent Rajkumar </strong></a></p><p><a href="coreimpodcast.com/2025/01/22/monoclonal-gammop…; rel="nofollow"><strong>Transcript and Show Notes</strong></a></p><p><strong>Timestamps:</strong></p><p>(01:26) | Pearl 1: What is a monoclonal gammopathy? What is our expected clinical presentation?</p><p>(10:12) | Pearl 2: What is our initial workup? Understanding SPEP, Immunofixation, and Free Light Chains</p><p>(24:13) | Pearl 3: Do we need urine testing? When urine testing is necessary and when it is not.</p><p>(26:26) | Pearl 4: How should we differentiate monoclonal gammopathies? The continuum of MGUS, SMM, and MM.</p><p>(41:35) | Pearl 5: Demystifying Monoclonal gammopathy of clinical significance (MGCS)</p><p><br></p><p><strong>Tags:</strong> CoreIM, Internal Medicine, ClinicalPearls, Medical Education, IMCore, hospitalist, physician assistant, nurse practitioner, medical student, internal medicine</p><br /><br />Find the best disability insurance for you: patternlife.com/disability-insurance?campid=49… Sponsors:<br/>* Check out Eko: ekohealth.com<br/>* Check out FIGS and use my code FIGSRX for a great deal: wearfigs.com<br/><br/><br/>A… Inquiries: <a href='redcircle.com/brands'>https://redcircle… & Opt-Out: <a href='redcircle.com/privacy'>https://redcircl…;