#175 A Revolution in HIV Prevention & The PURPOSE Trials: Beyond Journal Club Segment with NEJM Group

<p><strong>How good are we at preventing HIV?</strong> How do <strong>efficacy</strong> and <strong>effectiveness</strong> differ? We journey from <strong>oral pre-exposure prophylaxis (PrEP)</strong> to <strong>long-acting injectables</strong>, and then to the <strong>PURPOSE trials</strong>, which look at the use of <strong>long-acting lenacapavir</strong> as PrEP — a potential <strong>game-changer in the field of HIV</strong>.</p><p>Listen to this latest episode of <strong>Beyond Journal Club</strong>, a collaboration between <strong>CoreIM</strong> and <strong>NEJM Group</strong>, where we <strong>put research into context</strong>, telling the story of how we arrived at the <strong>current standard of care</strong>, appreciating the <strong>clinical question</strong> of the trial at hand, and interpreting what the <strong>findings may mean for these patients</strong>.</p><p><br></p><p>🔹 <strong>Sponsor</strong>: <strong> NEJM Fellowship Program, click </strong><a href="coreimpodcast.com/NEJMFellowship"; rel="nofollow"><strong>here to learn more and/or apply</strong></a><strong>!</strong></p><p><br></p><p>🔹 <a href="coreimpodcast.com/2025/04/16/a-revolution-in-h…; rel="nofollow"><strong>Transcript and Show Notes</strong></a></p><p><br></p><p><strong>Timestamps:</strong></p><p>(02:25) | <strong>HIV PrEP Daily Truvada and Descovy </strong></p><p>(07:48) | <strong>On-Demand Prep</strong></p><p>(13:25) | <strong>Purpose Trials</strong></p><p>(20:56) | <strong>Discussion of Effectiveness to Efficacy </strong></p><p><br></p><p><strong>Tags:</strong> CoreIM, Internal Medicine, Primary Care, Medical Education, IMCore, Physician Assistant, Nurse Practitioner, Medical Student, HIV Prevention, Infectious Disease </p><br /><br />Find the best disability insurance for you: patternlife.com/disability-insurance?campid=49… Sponsors:<br/>* Check out Eko: ekohealth.com<br/>* Check out FIGS and use my code FIGSRX for a great deal: wearfigs.com<br/><br/><br/>A… Inquiries: <a href='redcircle.com/brands'>https://redcircle… & Opt-Out: <a href='redcircle.com/privacy'>https://redcircl…;