A history of prolactin

This episode charts the century-long history of prolactin research, tracing how scientists mapped its complex neuroendocrine regulation. We begin with the discovery of its lactogenic properties in 1928 and the paradigm-shifting realization that the hypothalamus exerts tonic inhibition over its release via tuberoinfundibular dopamine neurons. The discussion covers the identification of stimulatory factors like thyrotropin-releasing hormone, estrogen, and oxytocin, the molecular characterization of short-loop negative feedback, and its modern reemergence as a vital metabolic regulator.