Multiple Endocrine Neoplasia Type 1

Multiple endocrine neoplasia type 1 arises from inactivating MEN1 tumor suppressor mutations, causing loss of menin function. Clinical manifestations classically feature primary hyperparathyroidism due to multiglandular hyperplasia, enteropancreatic neuroendocrine tumors, and anterior pituitary adenomas. Management prioritizes subtotal parathyroidectomy with transcervical thymectomy, specialized biochemical surveillance, and aggressive multi-phase imaging to detect malignant functional pancreatic lesions early.