Real world use of Palopegteriparatide

A long-acting parathyroid hormone prodrug engineered for continuous parathyroid hormone receptor type 1 activation via physiologic autocleavage. Once-daily administration maintains stable serum calcium and phosphate levels while lowering urinary calcium excretion. This physiologic replacement reduces hypercalciuria and nephrocalcinosis risks intrinsic to conventional therapy, enabling the elimination of therapeutic active vitamin D and large oral calcium supplements.