#11 — Francesco Pappone, Paradigma: Automating Science, AI Scientists, and the SPRIND Frontier AI Challenge

Can AI make the next great scientific discovery? Francesco Pappone, Co-Founder and CEO of Paradigma, explains his mission to automate scientific research—from building AI “mad scientists” to creating factories for discovery. We discuss why today’s models lack research intuition, how Flywheel helps humans and agents collaborate, and his prediction that the Riemann hypothesis won’t be solved by a human. We also explore founding an ambitious startup in Rome, the SPRIND Frontier AI Challenge, and why he believes culture is Europe’s biggest AI bottleneck.
Thank you for listening!
GUEST
Paradigma: paradigma.inc
Try Flywheel: flywheel.paradigma.inc
Contact Paradigma: founders@paradigma.inc
SPONSORS
ETH Juniors: ethjuniors.ch
ETH Student Project House: sph.ethz.ch
PODCAST LINKS
Europe on Edge: europeonedge.com
Europe on Edge on LinkedIn: Europe on Edge (linkedin.com/company/europeonedge)
SOCIAL
X: @fbar3000 (x.com/fbar3000)
LinkedIn: Filipe Barata (linkedin.com/in/filipe-barata)