How to study protein shapes with light | One-step Nanoscale Expansion ONE Microscopy | Dr. Ali Shaib

In this episode, we hosted Dr. Ali Shaib, Group Leader at the Institute of Neurophysiology, University Medical Center Göttingen. We explored One-step Nanoscale Expansion (ONE) microscopy – revolutionary imaging technology transforming structural biology and diagnostics.
Dr. Shaib shared how ONE microscopy enables the visualization of proteins at an unprecedented scale, and why neuronal receptors are such fascinating targets for structural studies. We also discussed how this technology has a potential role in Parkinson’s diagnostics.
Beyond science, we touched on work-life balance in research, the impact of preprint servers like BioRxiv, the role of social media in science communication, the Imaging for All initiative and the upcoming Göttingen Expansion Forum 2025.
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Timestamps
00:00:00 Introduction
00:03:10 Ali’s background
00:07:20 One-step Nanometer Expansion Microscopy
00:14:09 Imaging GABA receptors with ONE microscopy vs other techniques
00:16:12 Democratizing Microscopy
00:21:55 Parkinson’s diagnostics with ONE microscopy
00:32:20 Initial stages of ONE
00:35:38 Work-life balance and mental health
00:39:17 Peptide labeling
00:43:40 3D Structures from 2D planes
00:46:38 ONE and quantum computing - experimental approach
00:50:54 ONE microscopy in cells and tissues
00:53:06 BioRxiv impact on publications
00:55:32 Social media & science communication
00:58:12 Imaging for All
01:01:23 Göttingen Expansion Forum 2025 (GEF25)

Neuroscience and Beyond team:
Svilen Georgiev
Kristina Jevdokimenko
Ahsen Konaç Sayıcı
Beatriz Apgaua
Mels Akhmetali
Steffen Pöschel (intro music)
Klaas Kock (intro music)

#Microscopy #ONEmicroscopy #SuperResolution #Research #Health #Science #Innovation