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AI for Atoms: How Periodic Labs is Revolutionizing Materials Engineering with Co-Founder Liam Fedus
What happens when you apply the scaling laws of large language models to the physical work of atoms? Elad Gil sits down with Liam Fedus, co-founder at Periodic Labs, which is pioneering an AI foundation lab for atoms. Liam discusses how he
Andrej Karpathy on Code Agents, AutoResearch, and the Loopy Era of AI
What happens when AI agents can design experiments, collect data, and improve — without a human in the loop? Andrej Karpathy joins Sarah Guo on the state of models, the future of engineering and education, thinking about impact on jobs, and
From Coder to Manager: Navigating the Shift to Agentic Engineering with Notion Co-Founder Simon Last
Notion isn’t designing AI agents that just use tools. Their agents can autonomously build their own integrations, as well as write the code needed to finish a task. Sarah Guo sits down with Notion Co-Founder Simon Last to explore Notion’s r
How Capital is Powering the AI Infrastructure Buildout with Magnetar Capital Managing Director Neil Tiwari
By the end of 2026, AI capital expenditure is projected to hit nearly $700 billion. The question isn’t who has the best model, but who has the most creative financing to build out AI infrastructure and beyond. Sarah Guo is joined by Neil Ti
From SaaS to AI-First: How Companies Are Reshaping Innovation
In this episode of No Priors, Sarah and Elad dive into the evolving landscape of software, exploring how AI is transforming the traditional SaaS model. They discuss whether SaaS as we know it is coming to an end, what new business and sales
Rivian’s Roadmap to AI Architecture and Autonomy with Founder and CEO RJ Scaringe
Autonomous vehicle technology has moved past human-coded rules and into an era of neural networks and custom computer chips. And to solve the most difficult driving scenarios, electric vehicle company Rivian abandoned its original technolog
Introducing 4D Creation Open Beta: NPCs, 4D Worlds, and the Future of Gaming with Roblox CEO Dave Baszucki
From “virtual doppelgängers” to “real-time dreaming,” online gaming platform Roblox is using AI technology to build the “Holodeck” envisioned in science fiction decades ago. Sarah Guo and Elad Gil sit down with Roblox CEO Dave Baszucki at R
Why Cryopreservation is No Longer Science Fiction with Until Co-founder and CEO Laura Deming
What if we could pause biological time to wait for a cure for a disease? Thanks to innovations and research in reversible cryopreservation, this possibility is no longer just science fiction. Sarah Guo sits down with Laura Deming, CEO and c
No Priors Live: Building Durable Software in the AI Age with MongoDB President & CEO CJ Desai
Why are there only a handful of companies in the world with over $10 billion in pure-play software revenue? CJ Desai believes the reason is that products are replaceable, but platforms are forever. For No Priors’ very first live from MongoD
AI and the Future of Warfare with US Under Secretary of War Emil Michael
Today’s arms race looks a little different from those of the past. Under the Trump administration, the US Department of War (DoW) is deploying generative AI to millions of employees in order to maintain a strategic edge over our global adve
NVIDIA’s Jensen Huang on Reasoning Models, Robotics, and Refuting the “AI Bubble” Narrative
Even if ChatGPT never existed, the tech giant NVIDIA would still be winning. The end of Moore’s Law—says NVIDIA President, Founder, and CEO Jensen Huang—makes the shift to accelerated computing inevitable, regardless of any talk of an AI “b
The 2026 AI Forecast: Foundation Models, IPOs, and Robotics with Sarah Guo and Elad Gil
Pundits are screaming about the so-called “AI bubble.” But historically slow-to-adopt industries like medicine and law are actually embracing AI at an unprecedented speed. Sarah Guo and Elad Gil look ahead to 2026, breaking down the major t
The Future of Voice AI: Agents, Dubbing, and Real-Time Translation with ElevenLabs Co-Founder Mati Staniszewski
Imagine learning chess from a grand master, or negotiating tactics from an expert FBI hostage negotiator. ElevenLabs’ voice AI technology is making that unlock possible. Sarah Guo sits down with Mati Staniszewski, co-founder of ElevenLabs,
Scaling Legal AI and Building Next-Generation Law Firms with Harvey Co-Founder and President Gabe Pereyra
In just over three years, Harvey has not only scaled to nearly one thousand customers, including Walmart, PwC, and other giants of the Fortune 500, but fundamentally transformed how legal work is delivered. Sarah Guo and Elad Gil are joined
Sunday Robotics: Scaling the Home Robot Revolution with Co-Founders Tony Zhao and Cheng Chi
The robotics industry is on the cusp of its own “GPT” moment, catalyzed by transformative research advances. Enter Memo, the first general-intelligence personal robot, focused on taking on your chores to give back your time. Sarah Guo sits
How AI Will Accelerate Breakthroughs in Biotechnology with Benchling CEO Sajith Wickramasekara
Bringing new drugs to market is a costly, time-consuming endeavor. On top of that, most medicines fail at some point in the research and development phase. Sarah Guo is joined by Sajith Wickramasekara, co-founder and CEO of Benchling, a com
Meet Snowflake Intelligence: A Personalized Enterprise Intelligence Agent with Sridhar Ramaswamy
Snowflake is moving beyond the data warehouse. Its new Snowflake Intelligence is an agentic platform for every employee, not just data teams. Sarah Guo sits down with Snowflake CEO Sridhar Ramaswamy to discuss his first 18 months at the hel
The Best of 2025 (So Far) with Sarah Guo and Elad Gil
2025 has thus far been a year of great leaps and advances in AI technology. And Sarah and Elad have spoken with some of the most enterprising founders and scientific minds in the field of AI today. So we’re revisiting a few of our favorite
Reinventing the Developer Terminal with Warp Co-Founder and CEO Zach Lloyd
For decades, the developer terminal has remained largely unchanged. But for Warp CEO and co-founder Zach Lloyd, reinventing this core tool is the key to unlocking AI agents for coding, debugging, and automating the entire development proces
Unlocking the Road to Energy Abundance with Base Power CEO and Co-Founder Zach Dell
With demand from AI for energy already exploding, our electric grid is facing a crisis. Base Power CEO and co-founder Zach Dell is ready to re-architect its future from the ground up. Zach sits down with Elad Gil to talk about Base Power’s
Humans&: Bridging IQ and EQ in Machine Learning with Eric Zelikman
The AI industry is obsessed with making models smarter. But what if they’re building the wrong kind of intelligence? In launching his new venture, humans&, Eric Zelikman sees an opportunity to shift the focus from pure IQ to building models
The Impact of AI, from Business Models to Cybersecurity, with Palo Alto Networks CEO Nikesh Arora
Between the future of search, the biggest threats in cybersecurity, and the jobs and platforms of tomorrow, Nikesh Arora sees one common thread connecting and transforming them all—AI. Sarah Guo and Elad Gil sit down with Nikesh Arora, CEO
Reinventing K-12 Education Using AI with Alpha School Principal Joe Liemandt
What if kids could master their academics in just two hours a day and spend the rest of their time developing real-world skills they’re passionate about? Joe Liemandt, founder of the software company Trilogy, is doing just that. Sarah Guo a
AI Agents Talking to AI Agents: Reinventing Commerce with Decagon CEO Jesse Zhang
The traditional call center may soon be a thing of the past. Jessie Zhang is building AI agents designed to replace monotonous human labor and transform how consumers interact with brands. Elad Gil sits down with Jesse Zhang, co-founder and
Jared Kushner: BrainCo, Affinity Partners, and the Geopolitics of AI
From negotiating with world leaders to partnering with top entrepreneurs, businessman and investor Jared Kushner has traveled the unique path of bringing private sector knowledge to government work and back again. Jared Kushner joins Sarah
A New Operating System for Physicians with OpenEvidence Founder Daniel Nadler
How does a new technology get adopted by 40% of American doctors in just 18 months? In an era where the golden age of biotechnology has also created a dark age of physician burnout, OpenEvidence found the answer by fundamentally changing ho
Reshaping America’s Economy for the Superintelligence Century with Jacob Helberg
AI doomers say that the technology will be the ultimate job-killer. But Jacob Helberg wants people to see AI as a tech that will boost, not replace, human workers and give them superpowers. Under Secretary of State for Economic Growth, Ener
How Agentic AI is Transforming The Startup Landscape with Andrew Ng
Andrew Ng has always been at the bleeding edge of fast-evolving AI technologies, founding companies and projects like Google Brain, AI Fund, and DeepLearning.AI. So he knows better than anyone that founders who operate the same way in 2025
Chips, Neoclouds, and the Quest for AI Dominance with SemiAnalysis Founder and CEO Dylan Patel
What would it take to challenge Nvidia? SemiAnalysis Founder and CEO Dylan Patel joins Sarah Guo to answer this and other topical questions around the current state of AI infrastructure. Together, they explore why Dylan loves Android produc
The Shifting Value of Content in the AI Age with Cloudflare CEO Matthew Prince
Cloudflare has spent nearly fifteen years making the Internet faster, more reliable, and more secure. So now that AI systems are changing the way we interact with the Internet, Cloudflare wants to help level the playing field for content cr