Psychopharmacology and Psychiatry Updates
KarXT: A New Era in Antipsychotics?
Samstag, 11. April 2026 · 13 min
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Shownotes
In this episode, we explore KarXT, a newly FDA-approved antipsychotic with a groundbreaking cholinergic mechanism, through the lens of a single powerful metric: the Number Needed to Treat. Could an NNT of 5 change how you approach treatment-resistant schizophrenia?
Faculty: Oliver Freudenreich, M.D. Host: Richard Seeber, M.D.
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• How Effective Is KarXT (Xanomeline-Trospium) for Schizophrenia? NNT and NNH Explained