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Psychopharmacology and Psychiatry Updates

Semaglutide for Clozapine-Induced Weight Gain: The COaST Trial

Mittwoch, 25. Februar 2026 · 13 min

MP3

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In this episode, we explore the groundbreaking COaST trial examining semaglutide for clozapine-induced weight gain in schizophrenia patients. Could GLP-1 agonists finally offer a real solution to one of psychiatry's most frustrating paradoxes—when the medication that saves lives simultaneously shortens them?
Faculty: Oliver Freudenreich, M.D. Host: Richard Seeber, M.D.
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• Earn 0.5 CMEs: Quick Take Vol. 78
• Does Semaglutide Reverse Clozapine-Induced Weight Gain in Schizophrenia? Results from the COaST Trial

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