The OPTIMUM Trial: A Roadmap for Treatment-Resistant Depression in Late Life

In this episode, we explore the OPTIMUM trial, a landmark study examining how to treat older adults with treatment-resistant depression when antidepressants fall short. When adding a medication outperforms switching entirely — and what that means for the patient sitting across from you — the answer may reshape your clinical approach.
Faculty: Scott Beach, M.D. Host: Richard Seeber, M.D.
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• Antidepressant Augmentation vs. Switching in Geriatric Depression: Key Findings from the OPTIMUM Trial