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Scaling Intelligence Out: Cisco's Vision for the Internet of Cognition, with Vijoy Pandey
Vijoy Pandey of Outshift by Cisco lays out his vision for an “Internet of Cognition,” where AI agents can share context, build reputation, and collaborate safely at scale. He offers a useful mental model for superintelligence: progress has
Your Agent's Self-Improving Swiss Army Knife: Composio CTO Karan Vaidya on Building Smart Tools
Karan Vaidya, CTO of Composio, explains how their “smart tool” platform lets AI agents access over 50,000 tools across 1,000+ apps through a single interface. He details how Composio handles tool discovery, authentication, sandboxes, and lo
Zvi's Mic Works! Recursive Self-Improvement, Live Player Analysis, Anthropic vs DoW + More!
Zvi Mowshowitz returns to survey the current AI landscape, from recursive self-improvement and the shift from the “beginning” to the “middle” of the AI story to what true AI end-game would look like. He and Nathan dig into AI-driven job los
AI Scouting Report: the Good, Bad, & Weird @ the Law & AI Certificate Program, by LexLab, UC Law SF
This special AI Scouting Report episode from the Law & Artificial Intelligence Certificate Program surveys the current AI landscape for legal professionals. Nathan Labenz walks through the “Good, Bad, and Weird” of frontier models, from usi
Bioinfohazards: Jassi Pannu on Controlling Dangerous Data from which AI Models Learn
Jassi Pannu, Assistant Professor at Johns Hopkins, explains how rapidly advancing AI is transforming biological research and raising the risk of engineered pandemics. They map today’s biosecurity landscape, from pathogen detection and DNA s
Try this at Home: Jesse Genet on OpenClaw Agents for Homeschool & How to Live Your Best AI Life
Jesse Genet shares how she built a team of AI agents to transform homeschooling, family life, and personal productivity without a software background. She explains how agents like an AI chief of staff, curriculum planner, and content creato
Don't Fight Backprop: Goodfire's Vision for Intentional Design, w/ Dan Balsam & Tom McGrath
Dan Balsam and Tom McGrath from Goodfire return to explore the frontier of mechanistic interpretability and their new research pillar, Intentional Design. They explain the shift from sparse autoencoders to understanding geometric structure
Situational Awareness in Government, with UK AISI Chief Scientist Geoffrey Irving
Geoffrey Irving, Chief Scientist at the UK AI Security Institute, explains why our theoretical understanding of machine learning remains fragile even as models surpass experts on critical security tasks. He details AISI’s work on frontier m
Universal Medical Intelligence: OpenAI's Plan to Elevate Human Health, with Karan Singhal
Karan Singhal, Head of Health AI at OpenAI, explains how ChatGPT Health is achieving attending-physician-level performance and already serving hundreds of millions of users. He details how OpenAI works with over 250 doctors, built the 49,00
Intelligence with Everyone: RL @ MiniMax, with Olive Song, from AIE NYC & Inference by Turing Post
Olive Song from MiniMax shares how her team trains the M series frontier open-weight models using reinforcement learning, tight product feedback loops, and systematic environment perturbations. This crossover episode weaves together her AI
Mathematical Superintelligence: Harmonic's Vlad Tenev & Tudor Achim on IMO Gold & Theories of Everything
Vlad Tenev and Tudor Achim from Harmonic explain how they built Aristotle, an AI system that reaches International Mathematical Olympiad gold-medal performance using formally verified Lean proofs. They unpack the architecture behind mathema
Approaching the AI Event Horizon? Part 2, w/ Abhi Mahajan, Helen Toner, Jeremie Harris, @8teAPi
Abhi Mahajan (@owlposting) explains how AI is reshaping biology and medicine, including foundation models to predict cancer treatment response and why he’s both skeptical and optimistic about current results. Helen Toner unpacks CSET’s “Whe
Approaching the AI Event Horizon? Part 1, w/ James Zou, Sam Hammond, Shoshannah Tekofsky, @8teAPi
Part 1 of this live special dives into AI for Science, U.S. AI policy, and the behavior of AI agents in open-ended environments. James Zou explains how interpretability and virtual labs of AI agents can accelerate scientific discovery. Sam
AGI-Pilled Cyber Defense: Automating Digital Forensics w/ Asymmetric Security Founder Alexis Carlier
Alexis Carlier, founder of Asymmetric Security, explains how assuming AGI-level intelligent labor should transform cybersecurity from reactive triage to proactive, continuous digital forensics. He breaks down today’s threat landscape—from “
Infinite Code Context: AI Coding at Enterprise Scale w/ Blitzy CEO Brian Elliott & CTO Sid Pardeshi
Blitzy founders Brian and Sid break down how their “infinite code context” system lets AI autonomously complete over 80% of major enterprise software projects in days. They dive into their dynamic agent architecture, how they choose and cro
The AI-Powered Biohub: Why Mark Zuckerberg & Priscilla Chan are Investing in Data, from Latent.Space
This crossover episode from the Latent Space podcast features Mark Zuckerberg and Priscilla Chan on the 10-year anniversary of the Chan Zuckerberg Initiative and their expanded Biohub vision. They discuss how a “Frontier Biology Lab” workin
AI & The Law: Changing Practice, Claude Constitution, & New Rights, w/ Kevin & Alan of Scaling Laws
Kevin Frazier and Alan Rozenshtein explore how AI is reshaping the legal profession, from “secret cyborg” lawyers using tools like Harvey to the uncertain future of junior associates and access to legal services. They discuss maximalist leg
The Internet Computer: Caffeine.ai CEO Dominic Williams on Unstoppable, Self-Writing Software
Dominic Williams, President & Chief Scientist of the DFINITY Foundation and CEO of Caffeine AI, explains the Internet Computer and his vision of a “sovereign cloud where AI builds the web.” He breaks down core innovations like the Network N
AMA Part 2: Is Fine-Tuning Dead? How Am I Preparing for AGI? Are We Headed for UBI? & More!
In this AMA-style episode, Nathan takes on listener questions about whether fine-tuning is really on the way out, what emergent misalignment and weird generalization results tell us, and how to think about continual learning. He talks candi
Pioneering PAI: How Daniel Miessler's Personal AI Infrastructure Activates Human Agency & Creativity
Daniel Miessler shares his Personal AI Infrastructure (PAI) framework and vision for a future where single human owners are supported by armies of AI agents. He explains his TELOS system for defining purpose and goals, multi-layered memory
Snowflake VP of AI Baris Gultekin on Bringing AI to Data, Agent Design, Text-2-SQL, RAG & More
Baris Gultekin, VP of AI at Snowflake, explains how “bringing AI to the data” is reshaping enterprise AI deployment under strict security and governance requirements. PSA for AI builders: Interested in alignment, governance, or AI safety? L
AMA Part 1: Is Claude Code AGI? Are we in a bubble? Plus Live Player Analysis
In this AMA episode, Nathan gives an update on his son Ernie’s cancer treatment and how frontier AI models are helping him navigate complex medical decisions. PSA for AI builders: Interested in alignment, governance, or AI safety? Learn mor
Building & Scaling the AI Safety Research Community, with Ryan Kidd of MATS
Ryan Kidd, Co-Executive Director of MATS, shares an inside view of the AI safety field and the world’s largest AI safety research talent pipeline. PSA for AI builders: Interested in alignment, governance, or AI safety? Learn more about the
Confronting the Intelligence Curse, w/ Luke Drago of Workshop Labs, from the FLI Podcast
This cross-post episode from the Future of Life Institute podcast features Luke Drago, co-author of The Intelligence Curse and co-founder of Workshop Labs, in conversation with Gus Docker. PSA for AI builders: Interested in alignment, gover
Controlling Tools or Aligning Creatures? Emmett Shear (Softmax) & Séb Krier (GDM), from a16z Show
Emmett Shear and Séb Krier debate whether today’s AI alignment paradigm—focused on control and instruction-following—is fundamentally flawed. PSA for AI builders: Interested in alignment, governance, or AI safety? Learn more about the MATS
The Great Security Update: AI ∧ Formal Methods with Kathleen Fisher of RAND & Byron Cook of AWS
Kathleen Fisher and Byron Cook dive into automated reasoning and formal verification as tools for building truly secure software systems. PSA for AI builders: Interested in alignment, governance, or AI safety? Learn more about the MATS Summ
AI 2025 → 2026 Live Show | Part 2
This year-end live show features nine rapid-fire conversations to make sense of AI’s 2025 and what might define 2026. PSA for AI builders: Interested in alignment, governance, or AI safety? Learn more about the MATS Summer 2026 Fellowship a
AI 2025 → 2026 Live Show | Part 1
This year-end live show features nine rapid-fire conversations to make sense of AI’s 2025 and what might define 2026. PSA for AI builders: Interested in alignment, governance, or AI safety? Learn more about the MATS Summer 2026 Fellowship a
AI's Energy & Water Demands: Sorting Fact from Fiction with Andy Masley
Andy Masley on AI energy and water use unpacks common myths and brings an Effective Altruism lens to the debate. PSA for AI builders: Interested in alignment, governance, or AI safety? Learn more about the MATS Summer 2026 Fellowship and su
Superintelligence: To Ban or Not to Ban? Max Tegmark & Dean Ball join Liron Shapira on Doom Debates
Max Tegmark and Dean Ball debate whether we should ban the development of superintelligence in a crossover episode from Doom Debates hosted by Liron Shapira. PSA for AI builders: Interested in alignment, governance, or AI safety? Learn more