The Gut-Brain Link That Could Change How We Understand Parkinson’s

Could Parkinson’s disease begin in the gut? It’s a question that challenges how we think about brain health, and one that today’s guest has spent years investigating.

I’m talking with Sarkis Mazmanian, PhD, a professor of microbiology at Caltech whose research explores how gut bacteria influence the brain. We discuss why the gut has become an important focus in Parkinson’s research and how understanding that connection could open new possibilities for treatment.

Here’s what we get into:

• How the bacteria in your gut communicate with your brain and may influence behavior

• Why digestive problems can show up years before the movement symptoms of Parkinson’s

• What mouse studies suggest about the microbiome and autism, and what we still need to learn in people

• Whether commercial microbiome tests and probiotics can deliver on their promises

• Ways to support your gut through food, sleep, movement, and managing stress

When someone comes into my office, I want to understand their whole story, including what was changing long before they came to see me. That’s what makes the gut connection so compelling in Parkinson’s. If changes are happening years before movement problems appear, could that give us an earlier opportunity to help? It’s a question worth asking, especially when the answer could mean more years of doing the things you love.

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