Building the Largest Health Data Ecosystem in the US | Datavant CEO Kyle Armbrester

It has been said that we don’t have “big data” in healthcare, but instead a large amount of “small data.”
In this episode, Halle speaks with Kyle Armbrester, CEO of Datavant and former CEO of Signify Health (acquired for $8B), about why healthcare data still moves the way it did decades ago and what it will take to modernize it at scale. Kyle reflects on building and leading large health tech companies and explains how fixing data flow could reduce administrative waste, improve security, and make care easier for patients and providers alike.
We cover:
• Why healthcare billing still happens after the fact and how that fuels administrative waste
• How missing data standards led to fax-based workflows and brittle systems
• Why healthcare data is such an attractive target for cyberattacks
• How clinical data can be shared digitally without being owned or resold
• Leadership lessons from scaling companies through IPOs and acquisitions
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About our guest:
Kyle Armbrester is Chief Executive Officer of Datavant, a healthcare data platform company with a mission to make the world’s health data secure, accessible, and actionable. Datavant operates the largest and most diverse health data exchange in the U.S., connecting more than 70 percent of the 100 largest health systems, all U.S. payers, and 300 plus real world data partners.
Previously, Kyle served as CEO of Signify Health, where he led more than 200 percent revenue growth, took the company public in 2021, and guided its acquisition by CVS Health in 2023 for approximately $8 billion. He later served on the CVS Health executive management team, overseeing healthcare delivery strategy and interoperability.
Earlier in his career, Kyle was Chief Product Officer and Head of Corporate Development at athenahealth, where he helped scale revenue from $320 million to $1.2 billion and launched the company’s partnership marketplace. Kyle has served on multiple healthcare boards and holds an MBA and AB from Harvard University.
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Chapters:
00:01:20 Introduction to Kyle Armbrester and his journey in healthcare
00:03:58 The impact of Athena Health on healthcare innovation
00:06:20 Datavant: Revolutionizing health data interoperability
00:08:15 The role of Datavant in reducing administrative burden
00:12:20 Understanding Datavant's value proposition across stakeholders
00:14:00 Consumer products and data accessibility at Datavant
00:18:25 The scale and impact of Datavant in healthcare
00:19:35 Cybersecurity challenges in healthcare data management
00:23:57 Bridging the gap in healthcare regulations
00:26:13 Unlocking the value of untapped healthcare data
00:29:25 Challenges of value-based care models
00:33:23 The reality of being a CEO in healthcare
00:37:00 Navigating IPOs vs. Acquisitions
00:39:44 Innovating healthcare incentives for better outcomes
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Pre-order Halle's new book, Massively Better Healthcare (massivelybetterhealthcare.com).
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