Matthias Preusser on the phase 2 TUXEDO-3 trial

Deputy Editor Ali Landman speaks with Matthias Preusser (Medical University of Vienna, Vienna, Austria) about two reports from the phase 2 TUXEDO-3 trial investigating patritumab deruxtecan (HER3-Dxd) in patients with active brain metastases of breast cancer or non-small-cell lung cancer.

Hear about the potential of HER3-targeted antibody-drug conjugates for brain metastases, why recruiting patients with active brain metastases to clinical trials is so important, and where the field is going next.

Click here to read the full article: Patritumab deruxtecan (HER3-DXd) in patients with active brain metastases of non-small-cell lung cancer (TUXEDO-3): a multicentre, single-arm, phase 2 trial (thelancet.com/journals/lanonc/article/PIIS1470…)00465-6/fulltext?dgcid=tlcom_podcast_acq-november-2025_lanonc)

Click here to read the full article: Patritumab deruxtecan (HER3-Dxd) in patients with active brain metastases of breast cancer (TUXEDO-3): a multicentre, single-arm, phase 2 trial (thelancet.com/journals/lanonc/article/PIIS1470…)00470-X/fulltext?dgcid=tlcom_podcast_acq-november-2025_lanonc)

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