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The TWIML AI Podcast (formerly This Week in Machine Learning & Artificial Intelligence)

von Sam Charrington

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Machine learning and artificial intelligence are dramatically changing the way businesses operate and people live. The TWIML AI Podcast brings the top minds and ideas from the world of ML and AI to a broad and influential community of ML/AI researchers, data scientists, engineers and tech-savvy business and IT leaders. Hosted by Sam Charrington, a sought after industry analyst, speaker, commentator and thought leader. Technologies covered include machine learning, artificial intelligence, deep learning, natural language processing, neural networks, analytics, computer science, data science and more.

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  1. The Brutal Reality of Building Agentic Products Today with Daniel Jeffries - #782

    AI agents are becoming accessible to everyone, raising the bar for developers building the next generation of agent products. When capable, general-purpose agents are available out of the box, differentiation increasingly comes down to the

  2. Airbnb Is Building a ‘Company Brain’ for AI Agents with Ahmad Al-Dahle - #781

    AI agents need the institutional knowledge experienced employees rely on: why a system works a certain way, which policies apply, and what never made it into the documentation. Capturing that knowledge is hard. Keeping it useful as people a

  3. Your Ranking Model Is Optimizing the Wrong Thing with Zoe Weil - #780

    In this episode, Zoe Weil, co-founder and CEO of Sequen, joins us to discuss how ranking systems can use live behavioral signals to optimize for purchases rather than clicks or search relevance alone. Zoe explains why approaches developed a

  4. Why Jev Is Changing How We Build With AI with Diogo Almeida - #779

    In this episode, Diogo Almeida, co-founder and CEO of TypeSafe, joins us to discuss Jev, TypeSafe’s recently released model for bringing fast, reliable intelligence directly into software. We explore the idea of “machine-native intelligence

  5. From Math Olympiads to Navier-Stokes: How Fast Is AI Progressing? with Greg Burnham - #778

    AI systems have gone from struggling with grade-school math to helping solve research problems that have resisted mathematicians for decades, including Navier-Stokes. In this episode, Greg Burnham, who leads AI capabilities research at Epoc

  6. From Voice Agents to AI Avatars with Alexander Smola - #777

    Voice AI has gotten remarkably good, but natural conversation remains a high bar. Small delays, awkward interruptions, or the wrong tone can quickly break the illusion—and adding vision and visual presence only raises the stakes. In this ep

  7. Do AI Tokenomics Matter More Than Model Benchmarks? with Chris Potts - #776

    As reasoning models consume more tokens and AI systems become more expensive to run, understanding what those tokens actually buy is becoming increasingly important. In this episode, Stanford professor and Big Spin co-founder Chris Potts jo

  8. World Models and the Future of Spatial AI with Justin Johnson - #775

    In this episode, Justin Johnson, co-founder of World Labs, joins us to discuss world models and the emerging field of spatial AI. We explore why many researchers see capabilities beyond language as an important frontier for AI, and what it

  9. Why the Next AI Breakthrough May Come from Physics with Max Welling - #774

    The conventional wisdom in AI is that the next breakthrough will come from more compute, more data, and larger models. But what if the next leap comes from somewhere else? In this episode, Max Welling—co-founder and CTO of CuspAI and profes

  10. Why Image Generation Needs More Than Bigger Models with Fatih Porikli - #773

    Text-to-image models have become remarkably good at producing realistic images. But realism isn’t the same as correctness. Ask for several distinct people, a specific composition, or a high-resolution image generated locally, and today’s mo

  11. Why Models Are AI’s Next Training Dataset with Damian Borth - #772

    For more than a decade, AI has advanced by training ever-larger models on ever-larger datasets. But as high-quality training data becomes harder to find and pretraining grows increasingly expensive, researchers are looking for new ways to k

  12. How AI Learns to Smell with Alex Wiltschko - #771

    In this episode, Alex Wiltschko, founder and CEO of Osmo, joins the show to discuss his goal of giving computers a sense of smell and what it takes to build olfactory intelligence. We explore the science behind smell, from the hundreds of o

  13. Why AI Agents Break the GenAI Security Model with Devvret Rishi - #770

    In this episode, Sam talks with Dev Rishi, GM of AI at Rubrik, about what happens when agents move beyond answering questions and start taking action across tools, systems, and business processes. We explore why the enterprise playbook of s

  14. Is RAG Dead? Lessons from Building AI for Tax Law with Alex Bowcut - #769

    As context windows grow into the millions of tokens, many AI practitioners are questioning whether retrieval-augmented generation (RAG) is still necessary. If modern models can ingest entire libraries of documents, why bother with retrieval

  15. Relational Foundation Models for Enterprise Data with Jure Leskovec - #768

    In this episode, Jure Leskovec, co-founder and chief scientist at Kumo and professor of computer science at Stanford, joins us to explore two fronts of his work: AI for science and relational deep learning. We begin with AI Virtual Cell, a

  16. How to Find the Agent Failures Your Evals Miss with Scott Clark - #767

    In this episode, Scott Clark, co-founder and CEO of Distributional, joins us to explore how teams can reliably operate and improve complex LLM systems and agents in production. Scott introduces a Maslow’s hierarchy of observability: telemet

  17. How to Engineer AI Inference Systems with Philip Kiely - #766

    In this episode, Philip Kiely, head of AI education at Baseten, joins us to unpack the fast-evolving discipline of inference engineering. We explore why inference has become the stickiest and most critical workload in AI, how it blends GPU

  18. How Capital One Delivers Multi-Agent Systems with Rashmi Shetty - #765

    In this episode, Rashmi Shetty, senior director of enterprise generative AI platform at Capital One, joins us to explore how the company is designing, deploying, and scaling multi-agent systems in a highly regulated environment. Rashmi walk

  19. The Race to Production-Grade Diffusion LLMs with Stefano Ermon - #764

    Today, we're joined by Stefano Ermon, associate professor at Stanford University and CEO of Inception Labs to discuss diffusion language models. We dig into how diffusion approaches—traditionally used for images—are being adapted for text a

  20. Agent Swarms and Knowledge Graphs for Autonomous Software Development with Siddhant Pardeshi - #763

    In this episode, Sid Pardeshi, co-founder and CTO of Blitzy, joins us to discuss building autonomous development systems able to deliver production-ready software at enterprise scale. Sid contrasts AI-assisted coding with end-to-end autonom

  21. AI Trends 2026: OpenClaw Agents, Reasoning LLMs, and More with Sebastian Raschka - #762

    In this episode, Sebastian Raschka, independent LLM researcher and author, joins us to break down how the LLM landscape has changed over the past year and what is likely to matter most in 2026. We discuss the shift from raw model scaling to

  22. The Evolution of Reasoning in Small Language Models with Yejin Choi - #761

    Today, we're joined by Yejin Choi, professor and senior fellow at Stanford University in the Computer Science Department and the Institute for Human-Centered AI (HAI). In this conversation, we explore Yejin’s recent work on making small lan

  23. Intelligent Robots in 2026: Are We There Yet? with Nikita Rudin - #760

    Today, we're joined by Nikita Rudin, co-founder and CEO of Flexion Robotics to discuss the gap between current robotic capabilities and what’s required to deploy fully autonomous robots in the real world. Nikita explains how reinforcement l

  24. Rethinking Pre-Training for Agentic AI with Aakanksha Chowdhery - #759

    Today, we're joined by Aakanksha Chowdhery, member of technical staff at Reflection, to explore the fundamental shifts required to build true agentic AI. While the industry has largely focused on post-training techniques to improve reasonin

  25. Why Vision Language Models Ignore What They See with Munawar Hayat - #758

    In this episode, we’re joined by Munawar Hayat, researcher at Qualcomm AI Research, to discuss a series of papers presented at NeurIPS 2025 focusing on multimodal and generative AI. We dive into the persistent challenge of object hallucinat

  26. Scaling Agentic Inference Across Heterogeneous Compute with Zain Asgar - #757

    In this episode, Zain Asgar, co-founder and CEO of Gimlet Labs, joins us to discuss the heterogeneous AI inference across diverse hardware. Zain argues that the current industry standard of running all AI workloads on high-end GPUs is unsus

  27. Proactive Agents for the Web with Devi Parikh - #756

    Today, we're joined by Devi Parikh, co-founder and co-CEO of Yutori, to discuss browser use models and a future where we interact with the web through proactive, autonomous agents. We explore the technical challenges of creating reliable we

  28. AI Orchestration for Smart Cities and the Enterprise with Robin Braun and Luke Norris - #755

    Today, we're joined by Robin Braun, VP of AI business development for hybrid cloud at HPE, and Luke Norris, co-founder and CEO of Kamiwaza, to discuss how AI systems can be used to automate complex workflows and unlock value from legacy ent

  29. Building an AI Mathematician with Carina Hong - #754

    In this episode, Carina Hong, founder and CEO of Axiom, joins us to discuss her work building an "AI Mathematician." Carina explains why this is a pivotal moment for AI in mathematics, citing a convergence of three key areas: the advanced r

  30. High-Efficiency Diffusion Models for On-Device Image Generation and Editing with Hung Bui - #753

    In this episode, Hung Bui, Technology Vice President at Qualcomm, joins us to explore the latest high-efficiency techniques for running generative AI, particularly diffusion models, on-device. We dive deep into the technical challenges of d

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