This Week in Startups

What VCs Really Think About Personal AI Agents | E2347

Donnerstag, 8. Oktober 2026 · 1 h 19

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Today’s show:

A personal AI agent that’s still invite-only just hit a $10 billion valuation. Guest host Deedy Das of Menlo Ventures is joined by Kanu Gulati of Khosla Ventures, Chris Farmer of SignalFire, and Sheel Mohnot of Better Tomorrow Ventures to debate whether Instinct can beat Meta’s Muse, what they actually use their own agents for, and what breaks when everyone’s agent makes the same move.

Plus we’re also talking about OpenAI’s math breakthroughs, the Factory vs. Cognition fight, and whether SaaS is still worth funding. Catch the whole debate on this week’s VC roundtable.

Guests:

Deedy Das on X: x.com/deedydas

Menlo Ventures: menlovc.com

Kanu Gulati on X: x.com/KanuGulati

Khosla Ventures: khoslaventures.com

Chris Farmer on X: x.com/chriswfarmer

SignalFire: signalfire.com

Sheel Mohnot on X: x.com/pitdesi

Better Tomorrow Ventures: btv.vc

Relevant Links:

OpenAI’s 722 math manuscripts from an unreleased internal model → github.com/openai/math

OpenAI’s earlier Navier–Stokes Millennium Prize result → openai.com/index/navier-stokes-solution

Pramaana Labs, the Khosla-backed startup turning tax rules into provable logic → pramaanalabs.ai

Logos Research, the Imperial College spinout verifying AI-written financial code → imperial.ac.uk/news/articles/2026/logos-resear…

EvenUp, SignalFire’s AI company for personal injury law → evenuplaw.com

WindBorne Systems, the Khosla-backed weather balloon company Kanu mentioned → windbornesystems.com

Gokul Rajaram’s X Post: x.com/gokulr/status/2107851356019290569?s=20

micro1, the AI training data company Chris and LAUNCH backs → micro1.ai

Vercel’s data on companies shifting to open-weight models → vercel.com/i/open-weight-models

Instinct raises $1B at a $10B valuation (SiliconANGLE) → siliconangle.com/2026/09/28/everyday-personal-…

Meta introduces Muse, its personal AI agent → about.fb.com/news/2026/09/introducing-muse-per…

Wajo, maker of the Fo agent Kanu uses → wajo.ai

Factory’s CEO accuses his board adviser of spying for Cognition (TechCrunch) → techcrunch.com/2026/09/30/factory-ceo-just-acc…

xAI rents its Colossus 1 data center to Anthropic (Data Center Dynamics) → datacenterdynamics.com/en/news/musk-spacex-xai…

Bending Spoons agrees to buy Miro, weeks after Airtable → investors.bendingspoons.com/newsroom/bending-s…

The FCC’s new rule on foreign-made robots → fcc.gov/covered-list-faqs-robots-inverters

Timestamps:

VC roundtable with guest host Deedy Das

If your work depends on conversations - interviews, meetings, calls - you need a Plaud NotePin S. You can check it out at plaud.ai/twist and use code TWIST for 10% off!

OpenAI's math results and what's left to invest in

Formalizing taxes and code so AI can prove its work

Why science breakthroughs still need the real world

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Can startups compete with the labs on compute?

Private data and vertical AI as the moat

Would you invest in AI training data companies?

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What a great founder looks like in the AI era

Quo (formerly OpenPhone) gives you a clean, modern way to handle every customer call, text, and thread all in one place. Try it free at quo.com/TWiST

Is Instinct worth $10 billion?

Can Muse reach a billion daily users?

Favorite personal agent use cases

What happens when everyone's agent makes the same call

Factory vs. Cognition and VCs backing rivals

Is SaaS still worth venture money?

Where the panel gets its information

What a seed fund means in 2026

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