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  1. Treating cost disease with Congressman Jake Auchincloss

    How can we build new cities in America? Which historical president is Trump most like? Why did immigration policy go so wrong? Sam and Pieter sit down with Congressman Jake Auchincloss to discuss the politics of the Abundance movement. They

  2. The art of protein design with AI

    What if you could design a protein never seen before? In this episode, Jacob and Saloni explore how researchers are using new tools like RFDiffusion, AlphaFold, and ProteinMPNN to ‘hallucinate’ entirely novel proteins: designing them from s

  3. Hacking proteins with AI

    Nature didn’t evolve all the proteins we need, but maybe artificial intelligence can help. Jacob and Saloni explore how tools like AlphaFold and ProteinMPNN are helping researchers re-engineer proteins, to make them safer, more stable, and

  4. How traffic modernism ruined cities with Nicholas Boys Smith

    Nicholas Boys Smith joins Ben and Sam to explain how to plan spaces that people like; dense, sociable and, above all else, beautiful. He says people don't like new buildings because they don't trust what planners and architects are going to

  5. 100 years of insulin in 15 minutes

    A hundred years ago, insulin was scraped from pig pancreases. Today, it’s made by bacteria in giant tanks. In the second part of a mini series on proteins, drug development and AI, Saloni tells the story of how insulin went from a crude ani

  6. Why feminism worked best in the West with Alice Evans

    Social scientist Alice Evans talks about why, despite a superficially similar feminist movement in East Asia, Western feminism has been much successful. Alice, Sam and Aria talk about dating markets, drinking culture at work, top-down media

  7. Proteins: Weird blobs that do important things

    This episode kicks off a mini-series on proteins, drug development and AI. Saloni and Jacob explore the world of proteins, including how proteins fold into complex shapes, why that complexity matters and how crowded and dynamic the inside o

  8. How to become President of China with Dan Wang

    Is it better to be run by engineers, lawyers or regulators? Can you build an economy on luxury handbags or do you need advanced manufacturing? Dan Wang, author of Breakneck: China's Quest to Engineer the Future (https://www.amazon.com/Break

  9. The underrated economics of land with Mike Bird

    Why is Chinese housing so expensive despite being oversupplied? How did land reforms in Russia lead to the Bolshevik revolution? What killed Georgism? The Economist’s Wall Street Editor, Mike Bird, discusses the underrated economics of land

  10. How Henry VIII accidentally started the Industrial Revolution, with Anton Howes

    Historian Anton Howes discusses how Henry VIII turned Britain into an economic backwater – making it the unlikeliest place for the Industrial Revolution to happen. But, he explains it only took a small cabal of people who understood the pro

  11. Stian Westlake on the intangible economy and paying for social science

    Why does London dominate Britain's economy, whereas Germany's is spread out across the whole country? Why don't restaurants scale well? What kind of social science research (if any) should the government be funding? Stian Westlake – Executi

  12. Samuel Hughes on The Great Downzoning

    Before the twentieth century, most cities were highly permissive about what people were allowed to build on their land. Nearly all Western householders lost these liberties during the first half of the twentieth century. Samuel Hughes calls

  13. Lenacapavir: The miracle drug that could end AIDS

    Lenacapavir is a new HIV drug that blocks infections with an efficacy rate of nearly 100%, and it could completely change the fight against HIV worldwide. Saloni and Jacob talk about the development and prospects for this new drug, as well

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