The Science of Drug Discovery: Insights from Artem Evdokimov

In this episode, drug discovery scientist Artem Evdokimov discusses the science of pharmaceutical development, from historical breakthroughs to the current landscape. He shares insights on antibiotics resistance, the obesity drug Ozempic, and technical details of drug screening methods like DNA-encoded libraries.
The conversation covers the economics of drug development, the potential of AI, and broader philosophical questions about human health and medicine. Evdokimov emphasizes the importance of avoiding oversimplification in science while highlighting both the triumphs and ongoing challenges in pharmaceutical research.
03:18 Historical Roots of Medicine
05:33 Evolution of Drug Delivery Methods
12:52 Modern Drug Discovery and Challenges
45:39 Understanding the Drug Discovery Process
47:30 Challenges in Gene Therapy
49:26 Complexities of Human Physiology
53:14 The Role of Receptors and Hormones
01:28:12 The Selenium Shortage and Shampoo Dilemma
01:28:54 Challenges in Drug Manufacturing and Distribution
01:34:23 Antibiotic Resistance: A Growing Concern
01:45:18 The Future of Drug Discovery and AI
02:11:01 Exploring AI and Drug Discovery
02:11:41 Outsourcing in Pharma: Pros and Cons
02:13:56 High Throughput Screening and Machine Learning
02:16:37 Challenges and Future of Drug Discovery

FOLLOW US ON SOCIAL:
Twitter @ x.com/632nmPodcast
Substack: 632nmpodcast.substack.com
Michael Dubrovsky @ x.com/MikeDubrovsky
Misha Shalaginov @ x.com/MYShalaginov
Xinghui Yin @ x.com/XinghuiYin
SUBSCRIBE:
Apple Podcasts: podcasts.apple.com/us/podcast/632nm/id1751170269
Spotify: open.spotify.com/show/4aVH9vT5qp5UUUvQ6Uf6OR
WEBSITE:
632nm.com