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Technical interviews with the greatest scientists in the world.
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Where Does Intelligence Live? | Michael Levin on Evolution, AI, and Platonic Space
What is intelligence, and where does it come from? Watch Part 1 here: https://youtu.be/t6EFV2gSSmg?si=VIztbK2CM5Nwj7QA In this episode, Michael Levin, professor of biology at Tufts University, returns to discuss his research into unconventi
AI, Cancer Vaccines, and the Future of Personalized Medicine | Sid Sijbrandij on GitLab + Biotech
Can AI help design personalized cancer vaccines? Visit Future of Cancer Care Today: https://sijbrandijfoundation.org/fcct In this episode, we speak with Sid Sijbrandij, founder of GitLab who went "Founder Mode" against his own cancer. Sid d
Building Quantum Computers at Semiconductor Scale | John Martinis on Qolab + Superconducting Qubits
What does it actually take to build a quantum computer that can scale to millions of qubits? Learn more about Qolab here: https://qolab.ai/ In this episode, we speak with John Martinis, recipient of the 2025 Nobel Prize in Physics. Martinis
Diffraction Limit, Microscopy, and Cell Biology | Eric Betzig on Super-Resolution Microscopy
What does a cell actually look like when you can see its molecules in action? In this episode, we speak with Nobel Prize-winning scientist Eric Betzig, whose pioneering work in super-resolution microscopy transformed our ability to see insi
The Hybrid Architecture Behind Quantum Computing | Yonatan Cohen Quantum Machines CTO
Why is controlling a quantum hardware becoming one of the biggest challenges in scaling quantum computers? In this episode, we speak with Yonatan Cohen, co-founder and CTO of Quantum Machines, a company developing advanced control systems f
How DNA Sequencing Was Discovered By Accident | Walter Gilbert on Biogen, Industry, and Art
How did we go from knowing almost nothing about genes to sequencing the entire human genome? In this episode, we speak with Nobel Prize-winning molecular biologist Walter Gilbert, whose discoveries helped lay the foundation for modern genom
How Bacteria Evolved Rotary Motors | Michael Manson
How do bacteria power one of the most sophisticated molecular machines in nature? In this episode, we speak with Dr. Michael Manson, one of the pioneers of bacterial motility research, whose nearly 50-year career has helped uncover how the
The Atomic Physics Behind Neutral Atom Computers | Mark Saffman
Why are so many companies betting on neutral atoms to build the first useful quantum computers? In this episode, we speak with Mark Saffman, professor at the University of Wisconsin–Madison and one of the pioneers of neutral atom quantum co
Silicon Photonics and the Future of AI Scaling | John Bowers
Why are some of the world's largest technology companies betting on silicon photonics? In this episode, we speak with John Bowers, professor at UC Santa Barbara and one of the pioneers of silicon photonics, about the technologies that are t
Bioelectricity, Morphogenesis, and Two-Headed Worms | Michael Levin
How can a flatworm regenerate a complete head after being cut in half? In this episode, we speak with Michael Levin, developmental biologist and director of the Allen Discovery Center at Tufts University, about the emerging field of develop
Quantum Architecture, QAOA, and Cancer Biomarkers | Fred Chong
Are quantum computers changing the way we discover cancer treatments? In this episode, Misha and Yudong spoke with Fred Chong, Seymour Goodman Professor at the University of Chicago, about the future of quantum computer architecture and how
How Quantum Sensors Can Measure Single Electrons | Amir Yacoby
How do you measure something as small as a single electron or map quantum behavior at the nanoscale? In this episode, Misha spoke with Amir Yacoby, professor at Harvard University, about the cutting edge of quantum sensing and the experimen
The Physics of Un-Hackable Face Recognition | Rob Devlin on Metalenz
How do you turn a flat piece of nanostructured material into a secure biometric sensor? In this episode, we speak with Rob Devlin, co-founder and CEO of Metalenz, about how metasurfaces are transforming optics and enabling a new generation
The Real Economics of Data Centers in Space | Starcloud CEO Philip Johnston
Are data centers in space physically possible, or just another overhyped idea? In this episode, we speak with Philip Johnston, CEO of Starcloud, about the technical and economic case for putting AI infrastructure in orbit. The idea has gone
How To Make Quantum Algorithms Cheaper | Craig Gidney on Magic-State Factories, Resource Estimates
How do you actually make quantum algorithms work on real hardware? Build your own quantum circuits in Crumble: https://algassert.com/crumble In this episode, we speak with Craig Gidney of Google Quantum AI, whose work focuses on the practic
How Neurons Translate Electricity into Chemistry | Tom Südhof
How do neurons convert electrical signals into chemical messages in under a millisecond? In this episode, we speak with Thomas Südhof, Stanford neuroscientist and Nobel laureate whose discoveries revealed the molecular machinery that allows
How Engineers Solve “Impossible” Problems | Dan Gelbart
How do engineers solve problems that seem to violate the laws of physics? In this episode, we speak with Dan Gelbart, a prolific inventor and precision engineer, about what it really means to work at the limits of physical law. From lasers
How Visual Experience Rewires the Brain | Mark Bear on Neuroplasticity
How does experience rewire the brain—and why is vision the ideal system for understanding neuroplasticity? In this episode, we speak with Mark Bear, MIT neuroscientist and a pioneer in the study of experience-dependent plasticity. Bear expl
Snell's Law, Metasurfaces, and Metalenses | Federico Capasso
How can flat surfaces shape light as powerfully as bulky lenses? In this episode, we speak with Federico Capasso, Harvard physicist and pioneer of metasurfaces, metalenses, and nanophotonics. Capasso traces the path from his work at Bell La
Graphene, Nanotubes, and Quantum Hall Physics | Philip Kim
How do electrons behave when they’re confined to a single layer, and why do entirely new laws of physics emerge when dimensions shrink? Papers discussed in this episode: Experimental observation of the quantum Hall effect and Berry's phase
Quantum Matter, Super-conductors, and Black Holes | Subir Sachdev on the SYK Model
What makes high-temperature superconductors and “strange metals” some of the most perplexing systems in modern physics? In this episode, we speak with Dr. Subir Sachdev: Harvard physicist and one of the leading architects of today’s underst
How to Build Fault-Tolerant Quantum Computers | Austin Fowler on Surface Codes + TQEC
Would we get a quantum computer sooner if everything was open source? In this episode, we speak with Austin Fowler, one of the architects of quantum error correction and a pioneer of the surface code used in today’s leading quantum computer
Why Syncing Atomic Clocks is Virtually Impossible | Judah Levine on UTC
Why is syncing atomic clocks still one of the hardest problems in physics and engineering? In this episode, we speak with Judah Levine—legendary NIST physicist and one of the key architects of modern timekeeping—about the invisible systems
Can We Predict History Like the Weather? | Peter Turchin on Cliodynamics
Why do civilizations rise, prosper, and then collapse? Here's what the math tells us. In this episode, we sit down with Peter Turchin, complexity scientist and founder of the field of cliodynamics, which uses data and mathematical models to
Why Do Quantum Computers Make So Many Mistakes? | Mikhail Lukin on Quantum Error Correction
You can’t copy a qubit. So how do quantum computers remember anything? In this episode, we sit down with Mikhail Lukin, Harvard physicist and co-director of the Harvard Quantum Initiative, whose lab is building quantum computers from arrays
We Interviewed the Winners of the Ig Nobel Prize | Ig Nobel 2025
The scientific stories behind this year's research that made people LAUGH, then THINK. Watch the 2025 Ig Nobel Ceremony here: https://youtu.be/z1cP4xKd_L4 In this episode, we bring together three of this year’s Ig Nobel winners whose resear
What Science can Learn from Startups | Adam Marblestone on Focused Research Organizations
Science has stalled. And Adam Marblestone thinks he knows why. Check out the Research Gap Map here: https://www.gap-map.org/?sort=rank In this episode, we sit down with Adam Marblestone, neuroscientist, nanotechnologist, and founder of Conv
What Optical Atomic Clocks Tell Us About Space-Time | Jun Ye
Times have changed. And cesium clocks can't keep up. In this episode, we sit down with Jun Ye, Joint Institute for Laboratory Astrophysics (JILA) Fellow and pioneer of optical lattice clocks, whose work has pushed timekeeping far beyond tra
Laser Cooling and Quantum Timekeeping | Bill Phillips
How did cooling atoms with lasers revolutionize our understanding of time? In this episode, we speak with Bill Phillips, Nobel Laureate in Physics, about his groundbreaking work on laser cooling and trapping of atoms: research that not only
Inside the Battle for Psychedelic Therapy | Rick Doblin
What does it take to turn a banned psychedelic into an FDA-approved medicine? Visit MAPS to read about the latest progress is psychedelic research: https://maps.org/ In this episode, we speak with Rick Doblin, founder of the Multidisciplina
