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Biology's Biggest Chicken and Egg Problem | Jacob Fine
Life’s First Blueprint Wasn’t DNA; it was RNA. Read Jacob Fine’s latest publication here: https://www.sciencedirect.com/science/article/pii/S0022283625001901 Today we spoke with Jacob Fine, graduate student researcher in Computational Biolo
The Final Interview with MIT Physicist Keith Johnson
One of Keith Johnson’s final interviews: a brilliant mind on dark matter, water, and fusion. Read about Keith’s legacy here: https://news.mit.edu/2025/keith-johnson-materials-scientist-independent-filmmaker-dies-0723 This episode is one of
How We Build Telescopes to Explore the Early Cosmos | Brian Keating
Did the Big Bang really happen? Telescopes, dark matter & cosmic origins explored. Join cosmologist Brian Keating as we explore the mysteries of the universe, from building telescopes at the South Pole to measuring the polarization of the c
Quantum Complexity: Scott Aaronson on P vs NP and the Future
In this episode of the 632nm podcast, Scott Aaronson shares his early fascination with calculus at age 11 and how “rediscovering” old mathematics led him toward groundbreaking work in complexity theory. He gives a lucid explanation of P vs
Science Memes, Epigenetic Inheritance, and Rethinking Peer Review
In this episode of the 632nm podcast, we explore cutting-edge ideas in epigenetics and academic publishing. Oded Rechavi reveals how C. elegans worms defy conventional genetics by passing on traits through small RNAs, and discusses how thes
Quantum Diamond Sensing: The Surprising Power of NV Centers
In this episode of the 632nm podcast, we explore how diamond-based nitrogen vacancy (NV) centers went from being a curiosity in gemstone physics to a transformative tool for precision magnetometry. You’ll hear how these tiny defects enable
Origin of Life, Thermodynamics, and God: Jeremy England
In this episode, Jeremy England reframes the origin of life debate by applying non-equilibrium physics, challenging the notion that life’s emergence must be purely biological or chemical. He describes how matter can “learn” from its environ
Flux Grant by 1517 Fund: Backing Garage Science and Sci-Fi Tech
In this episode of the 632nm podcast, we sit down with 1517 Fund’s Danielle Strachman and Michael Gibson to explore their Flux program, a unique pre-seed fellowship backing wild, unorthodox scientific and technical ideas. They share how the
Trapped Ion Quantum Computing: Christopher Monroe of IonQ
In this episode of the 632nm podcast, our guest traces the evolution from the early days of Bose-Einstein condensation experiments to pioneering trapped ion quantum gateways. He reveals how breakthroughs in laser cooling and atomic clock re
Maintaining Moore's Law: Lithography, Semiconductors, and Chip Fabrication with Mordechai Rothschild
In this episode of the 632nm podcast, we explore how 193nm lasers unexpectedly overtook x-ray approaches and reshaped semiconductor manufacturing. Physicist Mordechai Rothschild describes the breakthroughs that turned a once “impossible” te
Quantum Cascade Lasers: Federico Capasso on Curiosity and Bell Labs
In this episode, physicist Federico Capasso recounts his winding path from struggling undergrad to pioneering inventor of the quantum cascade laser. He reveals how openness, daring ideas, and the bottom-up ethos at Bell Labs led to breakthr
How Edison Inspired Eli Yablonovitch to Create Four World-Changing Inventions
Eli Yablonovitch shares how Thomas Edison's approach of requiring "a thousand failed discoveries for every one that works" shaped his scientific philosophy. From solar cells to semiconductor lasers to photonic crystals to cell phone antenna
From Failed PhD to Nobel Prize | John Mather’s Journey to Revolutionize Astronomy
Join the 632nm team as we sit down with Nobel laureate Dr. John Mather. From his childhood days of building radios and telescopes to leading NASA's groundbreaking COBE mission, learn how a spectacular failure during his PhD research unexpec
Hunting for Alien Artifacts | Avi Loeb
Join the 632nm team as we sit down with Harvard Professor Avi Loeb, in this fascinating exploration of astronomy, alien life, and the intersection of science and politics. From discussing the mysterious interstellar object that changed astr
Are We Doomed? | Dan Aronovich on Norbert Wiener's 1948 “Cybernetics”
In this episode, the 632nm team sits down with Dan Aronovich (Data Science Decoded Podcast) to explore predictions about technology and society, starting with MIT pioneer Norbert Wiener's remarkably prescient warnings about AI from 1948. Hi
Information, Entropy & Reality | MIT Professor Seth Lloyd on Quantum Computing
The 632nm team sat down with MIT professor Seth Lloyd for a mind-bending journey through quantum mechanics, information theory, and the early days of quantum computing. Lloyd shares fascinating stories from his pioneering work in quantum in
From Medieval Glass to Nobel Prize | Moungi Bawendi on Mastering Quantum Dots
In this episode, the 632 team interviewed Nobel laureate Moungi Bawendi, revealing his serendipitous journey to the discovery and development of quantum dots. From a summer internship at Bell Labs to an expired bottle of chemicals that cont
How a Vision Disorder Led to Shocking Brain Science Discoveries | Mark Bear on Neuroplasticity
In this captivating episode, we explore how Mark Bear's personal experience with congenital nystagmus sparked a revolutionary career in neuroscience. Mark shares his remarkable journey from struggling with a visual impairment to making grou
The Current Reality of Quantum Computing | Yudong Cao on Deploying Quantum for Real-Life Problems
In this eye-opening episode, former Zapata Computing CEO Yudong Chen reveals the sobering truth about quantum computing's potential impact on drug discovery and the industry's inflated market expectations. Chen explains why even with perfec
From Failed Project to 40 Million Eye Scans: David Huang on the Birth of OCT
Dr. David Huang shares the remarkable journey of how a failed laser surgery project during his MD-PhD studies at MIT led to the invention of Optical Coherence Tomography (OCT), now used in over 40 million eye procedures annually. The story
Origins of Life | Anna Wang on Artificial Cells and Nano-Robots
Origins of life researcher Anna Wang takes us on a fascinating journey through the latest theories about how life began, revealing why Darwin's "warm little ponds" are making a comeback and how ocean spray droplets may have served as nature
The Future of Fusion | Dennis Whyte on Nuclear Fusion and MIT Plasma Science
MIT Professor Dennis Whyte's path to becoming a fusion energy pioneer began with an unlikely source - a Ripley's Believe It or Not comic strip he read as a teenager in rural Saskatchewan. The comic described how a bottle of water could theo
Origins of Life | Jack Szostak on Basement Experiments to Nobel Prize-Winning Discoveries
Nobel laureate Jack Szostak takes us on a fascinating journey through his remarkable scientific career, from conducting dangerous chemistry experiments in his basement as a curious child to making groundbreaking discoveries about telomeres
The God Particle | Christoph Paus on Higgs Boson, CERN, and CMS
Professor Christoph Paus, a key figure in the discovery of the Higgs Boson at CERN's Large Hadron Collider, discusses his journey in high-energy physics, the challenges of leading large international collaborations, and the future of partic
Cold Atoms: Mikhail Lukin on Quantum Optics and Neutral Atom Computing
In this episode, Harvard Professor Mikhail Lukin discusses his pioneering work in quantum computing using neutral atoms. He shares the journey from his early work in quantum optics and electromagnetically induced transparency to developing
Einstein Was Wrong: John Clauser on Bell's Theorem and the Nature of Reality
In this episode, we sit down with Nobel laureate John Clauser to discuss his experiments from the early 1960’s, testing Bell's inequalities and quantum entanglement. Clauser shares the story of how, as a graduate student, he proposed testin
The Science of Drug Discovery: Insights from Artem Evdokimov
In this episode, drug discovery scientist Artem Evdokimov discusses the science of pharmaceutical development, from historical breakthroughs to the current landscape. He shares insights on antibiotics resistance, the obesity drug Ozempic, a
Optical Metatronics: Nader Engheta on Electromagnetics and Scientific Curiosity
In this episode of the 632nm podcast, Nader Engheta shares his journey and experiences within the field of electromagnetics, from his early days at the University of Tehran and Caltech, to his current research in optical metatronics and non
Quantum Computing: Peter Zoller and Ignacio Cirac on the Quantum Revolution
In this episode of the 632-nanometer podcast, we explore the evolution of quantum computing with theoretical physicists and experimentalists Peter Zoller and Ignacio Cirac, two pioneers in the field. They recount their personal journeys and
Gravitational Waves: Rainer Weiss (Nobel Prize 2017) on Laser Interferometer Observation
In 1916, Einstein predicted the existence of gravitational waves, however, it took almost a century for researchers to detect them. In this episode of the 632-nanometer podcast, the team has a fireside chat with Rainer Weiss, the man behind
