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The $50,000 Underwater Drone - EP 66 Ulysses
Guinness. Sharks. American manufacturing. These are a few of the interests I share with the founders of Ulysses, a San Francisco startup building autonomous underwater drones. The idea for Ulysses started when one of the four co-founders wa
The Very Wild, Very Real Plan To Build AI Data Centers In The Ocean - EP 65 Garth Sheldon-Coulson
We’re in a moment of insatiable desire for more energy and more computing. And so the ideas of how to provide said energy and computing are getting ever more adventurous. Case in point: Panthalassa (https://panthalassa.com/), which is the s
The Company Helping Paralyzed People Move And Thrive Again - EP 64 Dave Marver
Three years ago, I’d caught some videos online of paralyzed people walking again. This struck me as miraculous. It also confused me. If paralyzed people were moving again, why weren’t more people talking about this incredible occurrence? Th
He Hacked Finance And Is Now Building An AI CEO - EP 63 Pedro Franceschi
Pedro Franceschi taught himself to code when he was eight years old. At 12, he began receiving legal notices from Apple, asking him to stop hacking iPhones. By 14, he was making hundreds of thousands of dollars a year selling software and h
Here Come The Space Lasers - EP 62 Baiju Bhatt
Baiju Bhatt is trying to pull an Elon Musk. About 25 years ago, Musk sold his finance tech company PayPal and left dot-com life to get into rockets with the founding of SpaceX. Hardly anyone considered this a rational choice on Musk’s part.
The Aussie Man Who Used AI To Create A Cancer Cure For His Dog
We have tracked down the man and dog of the hour. Paul Conyngham and his dog Rosie gained worldwide attention over the past week for breaking new medical ground. Using a variety of artificial intelligence tools, Conyngham – and some doctors
Inside The Race To Reboot Human Cells - EP 60 Nabiha Saklayen
The mainstream media says almost nothing about induced pluripotent stem cells (iPSCs). So, you’re lucky that we’re here to help. These cells with a clunky name hold the promise of being able to reverse the aging process across our bodies. P
He Thinks AI Code May Break Everything - EP 59 Will Wilson
Will Wilson paints a bleak picture for where we’re heading with code written by AIs. He thinks the world will fill with poorly written code that no one understands and that software bugs will proliferate through critical systems. Your airpl
She Survived Being Shot, Bombed And Working At Google - EP 58 Anna Prouse
Anna Prouse has survived multiple assassination attempts. She’s been tapped by General David Petraeus to get work done in Iraq that U.S. troops couldn’t handle. She’s faced off against Iranian militants. Over a multi-decade career working i
The Grand Quest To Simulate Life - EP 57 Ed Boyden
Ed Boyden has spent the last twenty or so years building the technology needed to create a working simulation of living systems. Put another way – he’s been trying to turn biology into physics. Boyden has helped develop new techniques for i
What's Real And What's Fake In Tech - EP 56 Peter Barrett
We do not usually do venture capitalists on the Core Memory podcast. They can be a lot and like to hear themselves talk a bit too much. (Not you! The other ones – Ed.) But, for Peter Barrett, we will always make an exception. He’s a general
The Joy And Doom Of New San Francisco - EP 55 Jayden Clark
The center of the universe has been born again. The most insufferable posters on our timeline, including myself, are enjoying the abundance found in San Francisco thanks to the AI boom lining the pockets of fresh college dropouts. The theme
The Present And Future Of Gene Editing - EP 54 Jennifer Doudna
Let’s get right to the point: Nobel Prize winner Jennifer Doudna is on the pod this week. Doudna won the 2020 Nobel Prize in Chemistry alongside Emmanuelle Charpentier for their work developing “a method for high-precision genome editing.”
He Left OpenAI To Think Bigger - EP 53 Jerry Tworek
On January 5th, famed AI researcher Jerry Tworek stunned world+dog by announcing (https://x.com/MillionInt/status/2008237251751534622) his departure from OpenAI. A few days later, he hopped over to the Core Memory podcast studio for his not
Welcome To The Chinese Peptide Underground - EP 52 Jasmine Sun
Biohacking has gone through a lot of different phases. Implanting an NFC chip in your hand is old school and having a blood boy is passé. Among Silicon Valley’s 20-somethings, all the cool kids have a peptide stack. Jasmine Sun joins us thi
New, More Precise Cancer Therapies Could Soon Be Here - EP 51 Richard Fuisz
We have a guest host and some breaking news for this episode. Eryney Marrogi (https://eryney.substack.com/), the scientist and soon-to-be doctor who writes for us now and again, has taken over the pod studio to interview Richard Fuisz (http
Is The Era Of AI-Designed Drugs Actually Here? - EP 50 Josh Meier and Jack Dent
We have been talking about computer-aided drug discovery for well more than a decade. It used to be the case that start-ups pitched their ability to use “machine learning” to hunt for new, promising therapies. Now we call machine learning “
The Next Step Toward Understanding The Nature Of Intelligence - EP 49 Sebastian Seung
Well, here we are. It’s brain uploading time. As we’ve just reported (https://www.corememory.com/p/exclusive-connectome-pioneer-sebastian-seuing-memazing), famed neuroscientist Sebastian Seung has created a new start-up called Memazing (htt
Attacking Cancer With Code And Winning - EP 48 Jake Becraft
Jake Becraft was working on mRNA way before it was cool. In fact, Becraft’s advisors at MIT told him trying to develop therapies with mRNA would be a colossal waste of time. But, here we are in 2025, and Becraft has pushed the mRNA technolo
America Has A Steel Start-Up. Yes, Really - EP 47 Laureen Meroueh
America has a new steel company, which is sort of a weird thing to write in 2025. It’s called Hertha Metals (https://herthametals.com/), and it’s based in Houston. It’s also run by a woman named Laureen Meroueh, who is this week’s guest. As
OpenAI's Research Chief On The Soup Wars, Poker And The Next Models - EP 46 Mark Chen
One must not feel sorry for Mark Chen. He gets paid very well to work in one of the most exciting fields imaginable. That said, as OpenAI’s Chief Research Officer, he has the difficult job of picking the company’s research priorities and of
The Famed Hacker Trying To Find The World's Best Inventors - EP 45 Pablos Holman
Pablos Holman has one of the most-watched (https://www.youtube.com/watch?v=hqKafI7Amd8) TED Talks of all time, and that’s sort of the least interesting thing about him. For the past 30 years or so, Holman has been traveling amid the most in
The Open Source AI Model For The West - EP 44 Misha Laskin
In December of 2024, the Chinese start-up DeepSeek shocked the world with the release of an AI model that appeared much cheaper to make and run than those from its American rivals. The company also open sourced its AI, meaning it released t
Aliens, AI, and Saving the Planet - EP 43 Will Marshall
Well, I wrote a book (https://www.amazon.com/gp/aw/d/0062998870/ref=tmm_hrd_swatch_0?ie=UTF8&qid=&sr=) and made a movie (https://www.hbomax.com/movies/wild-wild-space/55ee21e5-4295-4107-859a-a97decf2eebf) about this week’s guest, so he must
He Bought The First Tesla Roadster 2 In 2013 - EP 42 Konstantin Othmer
Over the past week or so, Elon Musk has started hyping up the launch of the long-, long-awaited Tesla Roadster 2. Musk appeared on the Joe Rogan podcast last week and said he hoped to unveil the car before the end of the year. (When it goes
Trump's Cyber Czar on China's Infiltration of America - EP 41 Joshua Steinman
Joshua Steinman spent four years (2017-2021) working for President Trump and had a very broad remit. He shaped all cyber, telecommunications, cryptocurrency, and supply chain policy. It’s fair to say the Washington press corps did not adore
She's Here To Make Dogs (And Then Humans) Live Longer - EP 40 Celine Halioua
Celine Halioua and her company Loyal are on track to deliver a drug next year that could help dogs live longer. Loyal’s therapy is aimed at senior dogs (10+ years of age) that weigh more than 14 pounds. It’s a pill that the dogs will take d
Now We Shall Mine The Oceans - EP 39 Gerard Barron
We know that there are trillions of dollars’ worth of minerals sitting on the ocean floor. The big question is whether humans should start hoovering them up. Our guest this week is very much Pro Hoover. He’s Gerard Barron, the head of The M
He's Building A Space Station For $1 Billion - EP 38 Jed McCaleb
Jed McCaleb grew up in Arkansas where he lived in a cabin in the woods that had no electricity or running water. Now, he’s a billionaire building a space station and funding some of the world’s most adventurous science. America remains a th
The State Of Gene Editing - EP 37 Eryney Marrogi
We have a proper treat this week. Core Memory special correspondent Eryney Marrogi (https://substack.com/@eryney) comes on the pod. Marrogi is a scientist and soon-to-be doctor who has followed the rise of the gene editing tools at humanity
