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Extend with Darshan Shah, MD is a podcast dedicated to cutting-edge science, research, tools, and protocols designed to help you extend your healthspan.
Starting my medical journey at 16 and becoming one of the youngest doctors in the country, studying and training at the Mayo Clinic, Harvard Business School, Singularity University and other prestigious institutions, becoming a board certified surgeon and accumulating over two decades of practice, I have discovered that a mere 20% of health knowledge yields 80% of the results.
That's why this podcast is all about cutting through the noise on how to turn back the aging clock.
I interview world-renowned medical practitioners, doctors, experts, and thought leaders, offering you a step-by-step guide and actionable advice to proactively avoid disease and optimize your health.
Plus, I share weekly solo episodes giving you quick, digestible protocols for successfully extending your healthspan.
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213. Nicole Bell: The Hidden Dangers of Lyme Disease—Brain Fog, Alzheimer's & Misdiagnosis
What if a negative Lyme disease test doesn't tell the whole story? And could an overlooked infection be contributing to symptoms like brain fog, chronic fatigue, or even cognitive decline? When Nicole Bell's husband began experiencing perso
212. Dr. Brad Goodman: The Truth About Chronic Back Pain & How to Avoid Surgery
What if the solution to your chronic back pain isn't another prescription, another injection, or even major spine surgery—but identifying exactly where your pain is coming from? Back pain is one of the most common reasons people lose mobili
211. Emma Heming Willis and Dr. Nicole Beurkens: Why Women Face a Higher Alzheimer's Risk—Menopause, Brain Fog & Prevention
What if the brain fog, forgetfulness, poor sleep, and mood changes so many women experience in midlife aren't just signs of getting older—but signals that their brains need more support? Women account for nearly two-thirds of Alzheimer's ca
210. Dr. Rena Malik: Why Erectile Dysfunction Could Be an Early Warning Sign of Heart Disease
What if problems in the bedroom were actually an early warning sign of something much bigger happening in your body? Most people think of sexual health as separate from their overall health. But erectile dysfunction, low libido, and changes
209. Dr. David Barzilai: Can We Reverse Aging? Harvard's Latest Longevity Science Explained
What if aging isn't just something that happens to us—but a biological process we can actually influence? For decades, medicine has focused on treating diseases after they develop. But a growing field called geroscience is asking a much big
208. Dr. Thais Aliabadi: PCOS & Endometriosis—The Symptoms Women Should Never Ignore
What if the painful periods, irregular cycles, unexplained weight gain, acne, and fertility struggles so many women experience aren't something they should simply learn to live with? Too often, women are told their symptoms are normal, thei
207. Dr. Jason Wersland: The Science of Recovery—Pain, HRV, Sleep & Your Nervous System
We spend so much time thinking about exercise, nutrition, and performance—but I believe recovery may be one of the most overlooked pieces of longevity. In this episode, I'm joined by Dr. Jason Wersland, chiropractor and founder of Therabody
206. Dr. Pamela Smith: The Truth About Hormone Replacement Therapy—HRT, Menopause & Cancer Risk
Hormones influence far more than reproductive health. They affect your sleep, mood, metabolism, muscle, bone health, brain function, stress response, and how you age—yet hormone health is still often reduced to a handful of numbers on a sta
205. Rajeev Kapur: How AI Is Transforming Healthcare
What if AI could change the way we understand, manage, and optimize our health? In today's episode, my guest is Rajeev Kapur, a leading AI advisor, educator, speaker, and author who helps non technical leaders understand how to turn artific
204. Dr. Cassie Smith: Fix Your Gut, Fix Your Hormones, Fix Your Health
What if your gut health is the missing piece behing your hormones, energy, metabolism, and how you feel every day? Today, I sit down with Dr. Cassie Smith, a double board-certiied endocrinologist and internal medicine physician who has take
203. Sat Randhawa: Can You Train Your Brain? QEEG & Neurofeedback
What if we stopped guessing about the brain and started measuring it? In today's episode, my guest is Sat Randhawa of One-Hype Wellness, where he and his team are focused on using brain mapping and neurotechnology to better understand how e
202. Dr. Colleen Cutcliffe: The Fiber-Gut Connection: How to Improve Your Microbiome, Blood Sugar & Cholesterol
Most people know they should eat more fiber. But what we're learning about fiber, gut health, and the microbiome goes far beyond digestion. Your gut contains trillions of microbes that depend on what you eat—and different types of fiber fee
201: Joey Munoz: The Truth About Nutrition, Protein, Weight Loss & Muscle
What if the biggest mistake you're making with your health isn't what you're eating - but the way you're thinking about nutrition in the first place? In this episode, I'm joined by Dr. Joey Munoz, a PhD in Nutrition Science and an evidence-
200. Dr. Will Cole: How to Heal Your Cells—Mitochondria, Peptides & the Science of Aging
What if the fatigue, brain fog, low energy, and other symptoms we associate with getting older actually begin much deeper—at the level of our cells? I've followed Dr. Will Cole's work for years, and his approach to gut health and functional
199. Dr. Jeffrey Wiegers: Stem Cells Explained—What They Can Do Now & What's Coming Next
What if medicine could do more than manage disease—and actually help the body repair itself? Regenerative medicine is moving quickly, but the world of stem cells, PRP, exosomes, and cellular therapies can be incredibly confusing. In this co
198. Dr. Bryce Appelbaum: Your Eyes Are Connected to Everything—Focus, Balance, Brain Health & Aging
What if your eyesight is 20/20—but your vision still isn't working the way it should? Dr. Bryce Appelbaum specializes in functional vision and the connection between the eyes and the brain. In this conversation, he explains why seeing clear
197. Ben Greenfield: When Biohacking Goes Too Far—What Actually Matters for Longevity
What happens when optimizing your health starts taking over your life? Ben Greenfield has spent decades at the forefront of biohacking, fitness, human performance, and longevity—testing the technologies, tracking the biomarkers, competing a
196: Dr. Jill Carnahan: Is Mold Making You Sick? Hidden Toxins, Symptoms & Detox
What if the fatigue, brain fog, inflammation, or unexplained symptoms you're experiencing aren't starting inside your body—but in the environment around you? Dr. Jill Carnahan knows this story from both sides of the exam room. At just 25, w
195: Jeff Byers: Inside the Supplement Industry: The 4 Supplements That Actually Matter
Walk into any supplement aisle—or scroll through social media—and you'll find thousands of products promising better energy, performance, brain health, and longevity. But which supplements actually work? And how do you know what's really in
194: Dr. Mark Hyman: Why You're Still Sick—Finding the Root Cause With Functional Medicine
What if the reason you're still sick isn't because there's no answer—but because no one has looked deeply enough for the root cause? My guest, Dr. Mark Hyman, is one of the world's leading voices in functional medicine, a bestselling author
193: Dr. Sasha Hamdani: ADHD, Anxiety and How to Regulate your Emotions
What if ADHD isn't just an attention problem—but also a problem of emotional regulation? My guest, Dr. Sasha Hamdani, is a board-certified psychiatrist, ADHD specialist, author, and someone who has lived with ADHD herself. She brings a uniq
192: Dr. Perlmutter: How to Protect Your Brain From Alzheimer's & Cognitive Decline
What if your risk of Alzheimer's isn't predetermined by your genes—but influenced by the metabolic health of your brain? My guest, Dr. David Perlmutter, is a board-certified neurologist, six-time New York Times bestselling author, and one o
191: Kiran Krishnan: How to Rebuild Your Gut Microbiome & Reduce Inflammation
What if the biggest mistake we're making with gut health is treating the microbiome like a list of bacteria instead of a living ecosystem? Your gut is home to trillions of microorganisms that influence inflammation, metabolism, immune funct
190. Dr. William Harris: 90% of Americans Are Low in This Critical Longevity Nutrient
What if one of the most important markers for your heart, brain, and longevity is something most people have never measured? AND roughly 90% of Americans aren't in the optimal range for? In this episode, I sit down with Dr. William Harris,
189. Dr. Florence Comite: The 5 Biomarkers That Predict How You'll Age
What if aging isn't something you simply accept - but something you can measure, predict, and even reverse? Most of us are told our lab work is "normal," yet chronic disease often develops silently for years before symptoms appear. Dr. Flor
188. James Beshara: How to Find Productivity Without the Hustle
We're living in a culture that celebrates being busy. More coffee. More hours. More hustle. But what if those things are actually making you less productive? The truth is, many high performers are stuck in a cycle of chasing energy instead
187. Dr. Izabella Wentz: 30+ Root Causes Behind An IBS Diagnosis
Hashimotos isn't just a thyroid disease-it may actually begin in the gut. If you've been told your thyroid labs are "normal" but you still struggle with fatigue, bloating, constipation, IBS, or autoimmune symptoms, this episode could change
186. Raj Sisodia: The Inner Work Behind Better Leadership
A leader's unresolved pain rarely stays contained within that leader. It can show up as control, aggression, emotional distance, relentless pressure, or a workplace where people are treated as resources rather than human beings. The organiz
185. Dr. Neha Sangwan: The 5 Questions That Predict a Health Crisis Before It Happens
I have operated on patients whose bodies had been sending them warning signals for years before a crisis ever put them in front of me. Stress alone causes or worsens more than 80 percent of the illness I see, and most of it traces back to o
184. Dr. Sahil Chopra & Sagar Chopra: Why Your Sleep Apnea Machine Might Be Lying to You
Millions of people wear a CPAP machine every night, the standard breathing device prescribed for sleep apnea. They trust the number on the screen to tell them their sleep apnea is under control. I've had patients tell me they stopped using
