From First Principles· Staffel 2· Folge 27

Dream Engineering, the Proton Radius Puzzle, and an ALS Breakthrough (EP. 27)

Donnerstag, 26. Februar 2026 · 2 h 12

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Hosted by Lester Nare and Krishna Choudhary, this episode has three main stories: interactive dream engineering (yes, two-way “communication” during lucid dreaming), the proton radius puzzle finally getting resolved by a precision lab measurement, and a sobering but hopeful look at ALS—including a breakthrough “ALS-in-a-dish” model that could finally make drug screening translate to humans.
Summary
• Dream engineering — targeted cues + induced lucidity → dream-content biasing and measurable next-day performance gains.
• Proton radius puzzle — precision hydrogen spectroscopy resolves the decade-long discrepancy; normal hydrogen agrees with muonic hydrogen.
• ALS — a predictive iPSC motor-neuron model that correlates with patient survival and reveals a promising multi-drug synergy.
• Rundown — pulsar near the Milky Way center, AI decoding a Roman board game, hormones + evolution signals, and AI-in-the-loop protein engineering.
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