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Latent Space: The AI Engineer Podcast

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The main Latent Space podcast: AI engineering, Forward Deployed Engineering, AI for science, and ⚡ Lightning episodes. Other feeds: Engineering and FDE: podcast.latent.space/eng.xml; Science: podcast.latent.space/science.xml; Misc (Lightning and other shows): podcast.latent.space/misc.xml; Firehose (all available shows): podcast.latent.space/firehose.xml. Feed directory: latent.space/pods

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  1. ⚡ Building ChatGPT for Finance — Joseph Kim, OpenAI's Head of Financial Services

    <p>Watch the full show on YouTube: https://www.youtube.com/watch?v=v-d1WTqIULs</p><p><a href="https://www.youtube.com/watch?v=v-d1WTqIULs">Full show notes and links</a></p>

  2. Why Agents Love Supabase

    <p>AI agents are creating more software—and that changes what a backend needs to do. Supabase co-founders Paul Copplestone and Ant Wilson join swyx to discuss running long-lived workloads alongside the database, making schemas easier for ag

  3. How Anthropic ships the #1 LLM in the World safely: Separating the Brain from the Hands

    <p>Katelyn Lesse and Angela Jiang join Latent Space to explain the engineering behind the Claude Platform: launching Opus 5.5, separating the model’s “brain” from the agent’s “hands,” scaling APIs, and building reliable managed agents. A ne

  4. ⚡ An Eval for AI Scientists That Knows the Answer Key - Ian Quigley, Leash Bio

    <p>Watch the full show on YouTube: https://www.youtube.com/watch?v=vhPCo-8K78U</p><p><a href="https://www.youtube.com/watch?v=vhPCo-8K78U">Full show notes and links</a></p>

  5. Why AI Compute Comes in Rectangles — Erik Bernhardsson, Modal CEO

    <p>Warm welcome to Basil Chatha, our newest cohost from the Forward Deployed side of the AI Engineering world! We’ll be ramping up a new show with him and couldn’t pass up an interview with Modal’s CEO Eric on the occasion of their monster

  6. The Recommendation Engine for Commodity Traders — Anekha Sokhal, Moshi

    <p>Anekha Sokhal, CEO of Moshi, joins swyx to discuss building a recommendation engine for commodity traders, turning market data into useful signals, and designing AI that fits users’ workflows. Watch: YouTube · Moshi · Anekha 0:00 AI Engi

  7. AI for the Fortune 2000: How Tenex Builds an AI-Native SDLC — Alex Lieberman & CJ Hess

    <p>Alex Lieberman and CJ Hess join swyx at AI Engineer New York to discuss Tenex’s approach to AI-native engineering, paying for outcomes, MetaHarness, enterprise AI adoption and rebuilding SaaS. Show notes: Tenex: https://www.tenex.co/ Bui

  8. The Programmable Data Center — Evan Conrad, SF Compute

    <p>This was recorded on the sidelines of the new Compute Trading track at AIE NYC. Catch us next at AIE CODE, our last flagship for the top agentic engineers in the world. In the early days of cloud, former guest Martin Casado made somethin

  9. 🔬 Lab-in-the-Loop at Compute Speed — Ian Quigley, Leash Bio

    <p>A few years ago I stumbled upon Leash Bio’s Substack, and was hooked. Be it their Kaggle competition that showed that no, we really haven’t solved protein-ligand binding, or their crazy discovery that knowing a molecule’s author is perha

  10. Dyna-2: General Purpose Physical Agents with Hour-Long Autonomy — Jason Ma, Dyna Robotics

    <p>Watch along AIE NYC and join us at AIE CODE in SF next month! This episode includes a live demo of the Taku robot that is best enjoyed on YouTube. Last month, Dyna made waves by announcing Dyna-2, a world-action model pre-trained on one

  11. 🔬 Why AlphaFold Didn't Solve Protein Folding — Pushmeet Kohli, Google DeepMind & Sal Candido, Biohub

    <p>From the Bitter Lesson of AI scaling to the unsolved mysteries of protein folding, Google DeepMind’s Pushmeet Kohli and Biohub’s Sal Candido are rethinking what it takes to build AI that truly understands biology. In this special panel m

  12. 🔬 Synthesis Superintelligence: from Semiconductors to Superconductors — Periodic Labs’ Liam Fedus and Ekin Dogus Cubuk

    <p>It’s hard to believe that Periodic was only launched last September: One year later, it is considered one of the pre-eminent AI scientist labs, with dizzying talent density and astonishing progress in the autonomous lab buildout: Most pe

  13. ⚡️ Which GPU Clouds Are Actually Good? | ClusterMAX 3.0

    <p>Watch the full show on YouTube: https://www.youtube.com/watch?v=MWX36ZYnsm0</p><p><a href="https://www.youtube.com/watch?v=MWX36ZYnsm0">Full show notes and links</a></p>

  14. Academia is for Ambition — Alex Zhang, MIT

    <p>Last call for regular tickets for AI Engineer NYC! As an exclusive for Latent Space subscribers, the first 30 of you can take a 30% off code if it helps - for new tickets only, no refunds! See you in 2 weeks! While we tend to cover indus

  15. Why Dwarkesh is Wrong about Computer Use + How OpenAI shipped its Jev competitor in 1 Week

    <p>Three months ago Dwarkesh, who has been posting incredible blogs and episodes about RL, posted a framing question for his video essay on RLVR which upset a lot of Computer Use folks: We are no strangers to learning in public and are no s

  16. Claude Code’s Next Era — Thariq Shihipar, Anthropic

    <p>We are excited to have Anthropic share their latest AI x Finance work at AI Engineer New York ( https://ai.engineer/nyc/2026 ), coming up in 2 weeks! In case you’ve been under a rock, here’s a non-exhaustive list of what Anthropic has be

  17. OpenRouter: from Seed to Stripe — with OpenRouter’s Alex Atallah & AMP’s Anjney Midha

    <p>From the earliest days of open-weight models to becoming the neutral routing layer for more than 10 million developers, OpenRouter is one of the clearest bets that the future of AI will be multi-model. In this episode, OpenRouter co-foun

  18. Runway’s WorldPrompt and the Engineering of Real-Time Worlds

    <p>Earlier this month, world model company Runway introduced GWM Worlds 2, a research preview that “turns high-fidelity video and audio generation into real-time interactive simulation.” Runway calls this an “autoregressive diffusion” model

  19. 🔬 Bio-security is an AI Arms Race - Eric Nguyen (CEO, Radical Numerics)

    <p>The OpenAI → Hugging Face attack has people asking “what else do we need to worry about?” and Anthropic’s filters flag two things: cyber-security and biology. The natural question is: what about bio-security, then? Clem Delangue argues t

  20. 🔬 An Oscar, Two Asteroids, and the Algorithm in Your sklearn: John Platt on AI for Science

    <p>How often do you get to talk to a guest who has both an Academy Award and who invented textbook machine learning algorithms? John Platt has an Oscar, two textbook algorithms, two named asteroids, and an Erdos-Bacon number of 6. This was

  21. Jev: System One models for Prod, not God — with Diogo Almeida, CEO, TypeSafe AI

    <p>Tickets for AIE NYC now open, and apply for the invite-only AIE CODE. Join us! We have an unusual relationship with today’s guest: for years since coauthoring the InstructGPT paper, Diogo Almeida had been saying that API-available fronti

  22. ⚡️ A Worm With 302 Neurons Inspired Their Architecture — Ramin Hasani, Liquid AI

    <p>Watch the full show on YouTube: https://www.youtube.com/watch?v=V_9TCu_21SE</p><p><a href="https://www.youtube.com/watch?v=V_9TCu_21SE">Full show notes and links</a></p>

  23. Underwriting Superintelligence: Backing Agents you can Sue — Rune Kvist, AIUC

    <p>AIUC first got our attention with the NFDG backing, and have just announced a $40M series A today, with the most impressive industry advisor list we may have ever seen for an early startup behind AIUC-1, their agent standard backed by re

  24. Humanity’s Last Invention — Richard Socher of Recursive

    <p>At 1:09:00 we talk about the rise of AI x Finance, and AIE NYC is one month away - our hotel block is 97% sold out, get tix & travel ASAP - we will announce speakers from Bridgewater, Ramp, Coatue, Mastercard, Vanguard, Coinbase, Blackro

  25. 🔬 “We have foundation models for language, not for physics” — Anima Anandkumar, Bren Professor of Computing

    <p>A few years ago, Caltech Prof. and co-founder of Accelerated Understanding, Anima Anandkumar set out to develop the first open-source weather model with AI. Talking to experts in the field, she was met with skepticism. Weather is chaotic

  26. ⏭️ Forward Deployed: Voice AI on what works in 2026

    <p>Watch the full show on YouTube: https://www.youtube.com/watch?v=MwNvowwcZOo</p><p><a href="https://www.youtube.com/watch?v=MwNvowwcZOo">Full show notes and links</a></p>

  27. Simulation: the new Scaling Law — Joon Sung Park, Simile AI

    <p>When we first dicsussed the Summer of Simulative AI in 2024 we knew it would be a brief summer, but it has recently come back with a vengeance with SimGym in April and now Simile AI’s $2B Series B, backed by GreenOaks and Index Ventures

  28. ⚡️ Exo: Harnesses should see their own code and logs — Alex Krentsel, UC Berekeley / Google Research

    <p>Watch the full show on YouTube: https://www.youtube.com/watch?v=5lFD-34dhqE</p><p><a href="https://www.youtube.com/watch?v=5lFD-34dhqE">Full show notes and links</a></p>

  29. 🔬 The BioAI Phase Shift - Matthew McPartlon & Neil Patil, Chai Discovery

    <p>This January, four big AI × Pharma tools deals were announced at the huge JPM Pharma conference that takes over San Francisco every year. OpenAI-backed Chai Discovery (now worth $4B) was somehow at the heart despite being all of 2 years

  30. The Inference Engineering Masterclass — Philip Kiely & Ali Taha, Baseten

    <p>Watch the full episode on YouTube: We first covered Baseten last year when DeepSeek mania was at peak hype. Now they have raised a monster $13B round and become one of the new cohort of AI Infra decacorns that are (with Nvidia, Intel, an

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