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Possible: Lisa Su on semiconductors, compute, and big bets
What’s the role of semiconductors—and the companies that make them—in powering human progress? What does it look like to innovate thoughtfully in a landscape where the demand for power may be higher than the supply? With AI evolving faster
How AI can unlock life-saving cures, with Siddhartha Mukherjee
Discovering new medicines has long been a slow, inefficient, and expensive process. Siddhartha Mukherjee, esteemed cancer biologist and author of the Pulitzer Prize-winning book The Emperor of All Maladies, is looking to change that. That’s
Designing AI for people and the planet, with Aza Raskin
AI is rapidly changing what it means to be human, but is AI development truly human-centered? According to Aza Raskin, co-founder of the Center for Humane Technology, the answer is largely “no.” The man who invented the “infinite scroll” is
Baratunde Thurston wants us to reimagine our relationship with AI
How we decide to live with AI, at home or at work, will greatly impact our personal and professional futures. Baratunde Thurston, a comedian, writer, and commentator, has had a long career exploring what a harmonious relationship between hu
Could this be the future of K-12 education?, with Alpha School’s Joe Liemandt
Educators around the world are wrangling with AI in learning. At Alpha School, a private K-12 school based in Texas, students use AI-driven software to complete core subjects in about two hours’ time. They spend the rest of the school day w
Vibe coding and the one-person start-up, with Lovable's Anton Osika
“Vibe coding” is taking software development by storm, allowing users to build apps by simply chatting with AI. These tools will transform how digital products and companies are created – and who gets to create them. Anton Osika is the co-f
Rapid Response: Hollywood’s hottest AI partner, with Runway’s Cristóbal Valenzuela
AI tools are disrupting all types of creative content, and Runway AI is a pioneer making major waves in Hollywood. In this episode of Rapid Response, Runway’s co-founder & CEO Cristóbal Valenzuela dissects the company’s breakneck growth, th
How Harvey is reinventing legal work with AI
Law is one of the oldest professions in the world, a storied occupation steeped in traditions, where innovation can be challenging. Gabe Pereyra wants to change that with the power of AI. As Co-founder and President of Harvey, he’s creating
Arianna Huffington thinks AI could be a GPS for the soul
Personal health and wellness tools are on the rise as more people take ownership of their physical and mental well-being. Arianna Huffington, co-founder of The Huffington Post, believes AI is the key to unlocking small behavior changes for
How Microsoft is democratizing safe AI
Responsible AI is more than a buzzword, it’s a guiding principle at Microsoft. Sarah Bird, Chief Product Officer of Responsible AI, leads the company’s efforts to build and deploy AI products with responsibility at the core. She and her tea
The power of storytelling in VCs, with Jeffrey Katzenberg and ChenLi Wang
WndrCo is a venture capital firm that views storytelling as the foundation of every successful business, and for good reason. Its founding partner, Jeffrey Katzenberg, helped build DreamWorks into one of the most celebrated animation studio
Replay: How AI is shaping the job market, with Hilke Schellmann
This week, Pioneers of AI is bringing back one of our most thought-provoking conversations: How AI is transforming the job market. Hilke Schellmann, journalist and author of “The Algorithm,” has spent years diving into the impact of AI on w
Inside how The New York Times leverages AI
For years, news organizations have walked a fine line between embracing new and emerging technologies and safeguarding their IP and content from those same technologies. The New York Times is no exception when it comes to its relationship w
Back to school: How AI is transforming the classroom, with Sal Khan
It’s back-to-school season and questions about how AI is changing the classroom are top of mind for parents, students, and teachers. Sal Khan, the founder of Khan Academy, an education platform that pioneered online learning, is one of the
Can artists and AI coexist?
Award-winning visual artist Shantell Martin has made a name for herself through her signature black-line, graphic drawings that have scaled gallery walls and traced paths across Times Square. She's collaborated with iconic brands like Tiffa
Does OpenAI’s new model deliver on the hype? Inside GPT-5 with Jeremy Kahn
OpenAI has released the latest iteration of its flagship product, GPT-5. It arrives after much anticipation, but does it live up to the hype? Jeremy Khan, AI Editor at Fortune, returns to the show to break down what this new model can do. W
Possible: Alexis Ohanian on the future of online and offline communities
How do we build products and platforms that support a healthy, prosperous future? What will it take to “make the internet fun again?” Should kids be using AI? This week, serial entrepreneur and investor Alexis Ohanian—who co-founded Reddit
How Writer is helping Fortune 500 companies become AI-forward
As AI becomes a bigger part of the modern workplace, more companies are integrating agents into their workflows, redefining how employees and technology collaborate. At the forefront of this shift is Writer, a company deploying AI agents to
How Google DeepMind is building AI that can help humanity
Google DeepMind is the powerhouse artificial intelligence lab behind Google’s AI assistant, Gemini. It’s also behind the groundbreaking AI tool, AlphaFold, that can predict a protein’s 3D structure. DeepMind’s COO, Lila Ibrahim, who’s the f
Can AI talk us out of conspiracy theories?
From deepfakes to fabricated news, AI has been shown to generate convincing deceptive images and videos, increasing the spread of misinformation. David Rand, a professor of Information Science and marketing at Cornell University, is using t
How today’s AI giants mirror global empires of the past, with journalist Karen Hao
In her New York Times bestseller “Empire of AI,” journalist Karen Hao traces the rise of an intriguing and controversial tech giant: OpenAI. In years spent chronicling the company, she came to a theory of how OpenAI’s operating model mimics
What humans get (and don’t get) from AI, with MIT’s Pattie Maes
Artificial general intelligence, or AGI, is the next horizon that could match or surpass human thinking. Companies are investing billions in it, but not necessarily in projects to help humans with our memory, health, or well-being. MIT Medi
Possible: Latanya Sweeney on AI, trust, and privacy
How does the rise of AI impact our sense of what’s true? How can humans maintain a degree of individual privacy and unlock the benefits of AI while mitigating potential harms? In this episode, Reid and Aria sit down with data privacy pionee
Elias Torres wants to reach unicorn status with just 100 employees
Founders and entrepreneurs today are racing to build companies with the leanest teams possible. Elias Torres, founder and CEO of Agency AI, a B2B company that delivers personalized, AI-powered customer service, is doing exactly that. His go
Possible: Jane Goodall on hope, AI, and the natural world
What would it look like to keep all living creatures in the loop on the development of new technology? Reid sat down for a wide-ranging solo discussion with Jane Goodall on that very subject – and more. They talked about how to maintain hop
How to use AI to fight online image abuse, with Breeze Liu
AI is a powerful tool full of possibilities, but it also carries the potential for significant harm. One disturbing misuse is the creation of synthetic “revenge porn” through deepfakes, targeting anyone without consent. Breeze Liu, a surviv
Possible: Artful Intelligence, part 3, featuring Paul Trillo
What does it take to create something the world has never seen before? In this final episode of Artful Intelligence, Reid Hoffman and Chris McLeod explore what it takes to spark a creative revolution with filmmaker Paul Trillo. Using OpenAI
How to build robots that can live alongside us, with Cynthia Breazeal
Over the past several decades, the field of robotics has achieved remarkable milestones. Robots have been sent to Mars and to the deepest parts of the ocean. Cynthia Breazeal, a professor at the MIT Media Lab, believes there’s another front
Possible: Artful Intelligence, part 2, featuring Elise Swopes
How can you shape the future with AI to create the world you want to live in? Reid Hoffman and Chris McLeod explore this question with Elise Swopes, a trailblazing visual artist and educator blending AI with photography. Currently an evange
The hidden environmental costs of a single AI prompt, with Dr. Sasha Luccioni
You may have heard that AI is a bit of a resource hog. It requires so much electricity that scaling it could have a tremendous impact on the planet through the increase of emissions. So, what is the exact footprint you’ll leave the next tim
