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Practical Neurology Podcast

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  1. How do new cancer drugs affect our brains? A practical guide to immune checkpoint inhibitors

    Immune checkpoint inhibitors can significantly improve cancer survival rates. But resulting immune-related toxicities are common, requiring multidisciplinary cooperation between oncology and neurology. This episode, PN's podcast editor Dr.

  2. Guidelines on disease-modifying treatment in MS: a decade-long update

    The latest guidelines on disease-modifying treatment in multiple sclerosis (MS) from the Association of British Neurologists is discussed in this intercontinental podcast with perspectives from the UK, the USA, and Australia. Participants:

  3. Localisation myths, brain fog, and small fibre neuropathies - Editors' Highlights April 2025

    It's a podcast of pairs this time, for the latest issue of the journal. There's two hosts, two halves of the brain, two sides to a clinical debate, and two themes to the episode itself. Leading off is a discussion on peripheral neurology, t

  4. Intestinal obstruction, and new-onset refractory status epilepticus (NORSE) - Case Reports February 2025

    A puzzling pair of Case Reports from the most recent issue of the journal. First up (1:35) is a man in his mid-fifties, presenting with lumbar spine fractures, which then developed into confusion, vomiting, and abdominal pain. An x-ray show

  5. Stiff-person syndrome

    Intermittent painful spasms, stiffness and rigidity of the proximal and truncal muscles are only a few symptoms of the relatively uncommon Stiff-person syndrome (SPS). In this podcast, we delve into the characteristics and diagnosis of this

  6. Posterior cortical atrophy, mascara staining, and careers in stroke - Editors' Highlights February 2025

    The practice of neurology is constantly changing, and the papers in this issue exemplify that trend. On this episode, journal editors Dr. Geraint Fuller and Prof. Philip Smith discuss their highlights from the latest issue of Practical Neur

  7. Episodic headaches after travel, and declining cognition with treated HIV - Case Reports

    Two more fascinating Case Reports from the latest issue of the journal. The first case (1:15) is of a 57-yo woman, with an intermittent posterior headache, which had an associated bilateral pressure-like sensation. Her symptoms had begun on

  8. Championing general neurology

    It’s the Christmas Special for 2024! Joining Amy in the studio is Dr. Steven Lewis. Current secretary general of the World Federation of Neurology, Steven is based in the United States, where he works as a general neurologist. Their convers

  9. Diagnosing neuromuscular junction disorders: red flags and atypical presentations

    The often challenging diagnosis of neuromuscular junction (NMJ) disorders can be explained by suspicious red flags for the key differential diagnoses (mimics) and atypical presentations (chameleons). In the latest Editor's Choice paper podc

  10. Upward tingling, racing glaucoma and the toppling tower of frailty - Editors’ Highlights December 2024

    Neuromuscular junction disorders can present in a variety of challenging ways, with the potential to mislead neurologists. Journal editors Prof. Philip Smith and Dr. Geraint Fuller begin with this subject as they talk through the latest iss

  11. Postpartum paraesthesia, and myasthenia with melanoma - Case Reports

    The immune system is a recurring feature in the cases discussed in this edition of the Case Reports podcast. The first paper details the cases of two young women, sisters, presenting with overlapping conditions but resulting in tragically d

  12. Neurotoxicology’s top offenders

    "Could this presenting syndrome be caused by a neurotoxin?" Oftentimes neurologists will pass over toxins when diagnosing. Yet disease caused by neurotoxins is widespread, with many having quite typical syndromes. In the studio to discuss t

  13. Oligoclonal bands, methotrexate use, and inconclusive cases - Editors’ Highlights October 2024

    The surgical sieve and Occam's razor may sound like familiar diagnostic metaphors, but what about Crabtree's bludgeon? These are just a few of the tools touched on by journal editors Prof. Philip Smith and Dr. Geraint Fuller, as they discus

  14. Midnight tetraparesis, and morning dysarthria - Case Reports

    This month's cases both feature sudden onset neurological syndromes. The first case (1:23) is that of a 26-yo Brazilian man who awoke from sleep with weakness in all four limbs. The signs suggest a possibility of Guillain-Barré syndrome or

  15. Lessons and pitfalls of whole genome sequencing

    Genetic testing is a useful tool for any practising neurologist, but they must know how to interpret the results. This Editors' Choice podcast features two experts on the subject, Prof. Mary Reilly¹ and Dr. Christopher Record¹. They're in t

  16. Charcot-Marie-Tooth, steroid safety, and dusting off the old optokinetic drum - Editors’ Highlights June 2024

    Journal editors Prof. Philip Smith and Dr. Geraint Fuller discuss the August 2024 issue of Practical Neurology, with room for mystery, history and practical advice. In particular, they cover topics like whole genome sequencing, foot surgery

  17. Vacant spells, and bodybuilding hazards - Case Reports

    Two highly unusual cases in this edition of Case Reports. The first case describes a 64-yo woman presenting to the emergency department with a five day history of bizarre behaviours (1:45). A BBC radio show prompts her, out of character, to

  18. Why are brain banks so important, and what can they tell us?

    Neurodegenerative disease is the subject of this month's Editors' Choice podcast, with Dr. Patrick Cullinane¹ and Dr. Zane Jaunmuktane.¹ They join the podcast for an overview of brain examination, explaining the process of protein misfoldin

  19. Valproate restriction, sexual dysfunction, and neuropathology - Editors’ Highlights June 2024

    Journal editors Prof. Philip Smith and Dr. Geraint Fuller discuss the June 2024 issue of Practical Neurology, covering some of the interesting articles published this month. A number of difficult challenges and tradeoffs are featured, relat

  20. Ptosis with paroxysmal cough, and ”just another kinase” - Case Reports

    The first of this episode's two case reports features a 62-yo man, referred from ophthalmology with a drooping eyelid, chronic coughing, and excess sweating in the face provoked by eating (1:21). An MR scan finds abnormal deposits in his br

  21. A new guideline for spontaneous intracranial hypotension

    The first multidisciplinary consensus guideline for the diagnosis and treatment of spontaneous intracranial hypotension (SIH) has recently been published by the UK SIH Specialist Interest Group. Group members Prof. Manjit Matharu (1), Dr. I

  22. An underappreciated vitamin, eponymous syndromes, and drop attacks - Editors’ Highlights April 2024

    Journal editors Prof. Philip Smith and Dr. Geraint Fuller discuss the April 2024 issue of Practical Neurology, covering some of the interesting articles published this month. Topics include inconsistencies observed in functional gait, the c

  23. Tonic-clonic seizures, and persistent abdominal pain - Case Reports

    The first case for this issue's discussion is one of a young man with a history of involuntary jerks and photosensitivity (1:20). Several more seizures followed his initial presentation with a general tonic-clonic seizure. A number of exami

  24. Making the most of electroencephalography, with Dr. Nick Kane

    Neurophysiologists may "lock ourselves away in rooms looking at screens with wiggly lines on", but what are the applications in a clinical context for electroencephalography (EEG)? In this deep-dive episode, podcast editor Dr. Amy Ross Russ

  25. Gait analysis, CBT, and neurology book clubs - Editors’ Highlights February 2024

    Journal editors Prof. Philip Smith and Dr. Geraint Fuller discuss the February 2024 issue of Practical Neurology, covering some of the interesting articles published this month. The papers discussed touch on the use of electroencephalograph

  26. Periocular pain, and sciatic nerve thickening - Case Reports

    In the first case this episode, a 69-yo woman has developed severe pain around her right eye with blurring to the vision on that side (1:08), which prompts use of a "rediscovered" treatment technique by the ophthalmology department - (https

  27. Artificial intelligence for neurologists, with Prof. James Teo

    With artificial intelligence (AI) being declared the solution to many of the challenges faced in our personal and professional lives, Prof. James Teo (1) joins the podcast to set us straight on where AI tools fit into neurological practice.

  28. Climate change and the brain, with Prof. Sanjay Sisodiya

    In this extra episode of the PN podcast, recorded to coincide with the COP28 summit, podcast editor Dr. Amy Ross-Russell (1) speaks to Prof. Sanjay Sisodiya (2) about his paper, "The hot brain: Practical climate change advice for neurologis

  29. Editors’ Highlights of the December 2023 issue

    Practical Neurology Editors Phil Smith and Geraint Fuller talk you through the highlights of the December 2023 issue of the journal - https://pn.bmj.com/content/23/6/461 Please subscribe to the Practical Neurology podcast on your favourite

  30. Case Reports: Right side weakness, and progressive confusion

    Prof. Martin Turner (1) hosts Dr. Ruth Wood (2) and Dr. Xin You Tai (3), as they puzzle through two Case Reports from the latest issue of the Practical Neurology journal. The first case (1:11) is one of a 27-yo man, whose initial presentati

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