Psychopharmacology and Psychiatry Updates
Are Z-Drugs Safe in the First Trimester of Pregnancy?
Sonntag, 18. Oktober 2026 · 18 min
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Shownotes
In this episode, we review a JAMA Psychiatry study of over 4 million pregnancies examining first-trimester Z-drug exposure and congenital malformations. Dr. Amanda Koire explains why overall risk wasn't increased, what the neural tube defect signal means, and how to evaluate insomnia before prescribing.
Faculty: Amanda Koire, M.D., Ph.D. Host: Flavio Guzmán, M.D.
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• Are Z-Drugs Safe in the First Trimester of Pregnancy?