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1010: Fable 5 as Advisor: Anthropic's Two-Model Pattern for Smarter, Cheaper Agents
In Episode #1010, Jon Krohn digs into “the advisor strategy”, a clever pattern that pairs a fast, cheap executor model with a frontier-class advisor it can consult mid-task, all inside a single API call. Every agent builder faces the same t
1009: How AI Is Quietly Saving Lives, with Steve Mock
In Episode #1009, Steve Mock (investor at Blumberg Capital, five-time entrepreneur and creator of aisavedme.org), joins Jon Krohn to explore the quiet layer of everyday AI adoption that rarely gets documented. After his 84-year-old father a
1008: The AI-Native Startup Playbook
In Episode #1008, Jon Krohn digs into Anthropic's 35-page Founder's Playbook and pulls out the practical guidance for each of its four startup stages: Idea, MVP, Launch and Scale. AI has erased the three bottlenecks that historically gated
1007: How to Find Solid Career Ground in the AI Era, with 80,000 Hours Founder Ben Todd
Benjamin Todd, co-founder and President of 80,000 Hours and author of the new Penguin Random House book 80,000 Hours: How to Have a Fulfilling Career That Does Good, joins Jon Krohn for a major update on career strategy in the AI era, his f
1006: In Case You Missed It in June 2026
In this month's episode of ICYMI, hear from Chip Huyen, Andrey Kurenkov, Frank Basso and Gilbert Eijkelenboom, discussing why moats are shifting toward physical systems and accumulated product intuition, how Astrocade built vibe coding befo
1005: People Skills for Analytical Thinkers, with Bestselling Author Gilbert Eijkelenboom
Gilbert Eijkelenboom, bestselling author of People Skills for Analytical Thinkers and founder of the training firm MindSpeaking joins Jon Krohn to make the case that communication is a core data skill, not an optional extra. Gilbert shares
1004: Recursive Self-Improvement
Could an AI get good enough at AI research to build its own, more capable successor and kick off a compounding loop? That’s recursive self-improvement (RSI) and it surged into the conversation after Anthropic revealed that, as of May 2026,
1003: Building an AI Data Center End to End, with Lightning AI’s Frank Basso
Frank Basso, VP of Infrastructure at Lightning AI, joins Jon Krohn for a rare ground-level tour of the one layer of the AI stack the show had never covered in over a thousand episodes: the physical data center. Frank explains how Lightning
1002: Fable 5: The Full Story from Capabilities to Drama
Anthropic’s Claude Fable 5 was the most capable AI model ever released to the public and it lasted just three days before the US government forced it offline. Jon Krohn unpacks both halves of the story: what makes Fable 5 special, and why i
1001: How AI Erased My Career Moat, an Episode #1001 Special: Jon Krohn interviewed by Kirill Eremenko
For this episode #1001 special, the tables are turned: SuperDataScience founder Kirill Eremenko takes the host’s chair and Jon Krohn is the guest. They trace Jon Krohn’s path from an Oxford neuroscience PhD to a New York hedge fund to found
1000: Ten Years of the Super Data Science Podcast, with Jon, Kirill and Special Guests
For this landmark 1,000th episode and the show’s 10-year anniversary, host Jon Krohn is joined by SuperDataScience founder Kirill Eremenko, who hosted the podcast for its first 400-plus episodes before handing over the reins. In a first for
999: What's Left to Build When Software Is Free, with Chip Huyen
Chip Huyen joins host Jon Krohn for this milestone episode 999 to talk about her record-breaking book "AI Engineering" the most-read title on the O'Reilly platform last year and how the AI landscape has shifted since her last appearance. Ch
998: In Case You Missed It in May 2026
In this month’s episode of ICYMI, Jon Krohn explores how AI agents are simultaneously creating new risks and unlocking powerful new ways of working with data. Hear from Anneka Gupta, Cal Al-Dhubaib, Trevor Manz, Jazmia Henry, Jeremy Mumford
997: How This Text-to-Video-Game AI Startup Hit 20M Users
Dr. Andrey Kurenkov returns to the show to talk about Astrocade's astronomical growth from pre-alpha to over 20 million engaged users, what it actually takes to build a vibe-coding platform that scales, and how the broader AI landscape has
996: TrueFoundry’s Nikunj Bajaj on How to Get $100M Returns on AI Agent Deployments
TrueFoundry co-founder and CEO Nikunj Bajaj speaks to Jon Krohn about how enterprises like Nvidia and Siemens are realizing returns of over $100 million from single agent deployments, the AI gateway architecture that makes it possible to co
995: End-to-End Foundation Models for the Energy Industry, with Jazmia Henry
Jazmia Henry joins Jon Krohn to break down what it actually takes to build end-to-end foundation models for the energy industry. From wrangling decades of handwritten oil-and-gas documents into usable training data, to bespoke tokenizers, r
994: AI’s Putting Recent Grads Out of Work; Here’s How to Get Hired Anyway!
Unemployment for recent computer-science graduates now rivals rates for fine-arts and anthropology majors, and undergraduate CS enrollment fell 11% in 2025. In this Five-Minute Friday, Jon Krohn walks through the data on both sides of the d
993: How to Build AI-First Organizations, with Jacob Miller and Jeremy Mumford
For years, AI content has come in the form of “use this library, use this tool” tutorials that age out within months. Jacob Miller and Jeremy Mumford, co-authors of the brand new Wiley book Architected Intelligence, wanted to write somethin
992: Tokenmaxxing vs AI Hardware Bottlenecks
While “tokenmaxxing”, the social media trend of maximizing AI token consumption as a vanity metric, takes off online, the physical infrastructure behind AI is slamming into serious bottlenecks. In this Five-Minute Friday, Jon Krohn maps out
991: Pair Programming with AI in Your Python Notebook, with Dr. Trevor Manz
Dr. Trevor Manz of Marimo talks to Jon Krohn about Marimo Pair, an open-source agent skill that teaches coding agents like Claude Code how to drive a reactive Python notebook, reading cell state, running Python in the kernel, taking screens
990: Inside Mythos: Anthropic's Locked-Down Frontier Model
Anthropic has built a frontier AI model so capable at finding software vulnerabilities that it has decided not to release it to the general public. In this Five-Minute Friday, Jon Krohn breaks down Claude Mythos Preview, a general-purpose m
989: Security for Mythos-Era Agentic Risks, with Rubrik’s Anneka Gupta and Cal Al-Dhubaib
Rubrik’s Anneka Gupta and Cal Al-Dhubaib speak to Jon Krohn about cybersecurity measures, the risks AI in business might pose for malicious attacks, and why AI should be kept “boring.” Find out how Rubrik safeguards client data, what zero t
988: In Case You Missed It in April 2026
In this month’s episode of In Case You Missed It, Jon Krohn talks to guests about memory and education, and how artificial intelligence is continuing to help lower the barriers to access. Hear from Matt Glickman, Traci Walker-Griffith, Rich
987: AI Infrastructure, Ray, and Why Nonlinear Careers Win, with Linda Haviv
Linda Haviv talks to Jon Krohn about staying current on AI matters, why open-source technology is narrowing the gap in its race with proprietary models, and how being a content creator in tech is key to career growth and longevity. She emph
986: Building Hardware is Hard but AI Agents Help, with Kishore Subramanian
CTO of Propel Software Kishore Subramanian talks to Jon Krohn about how product lifecycle management (PLM) software and quality management systems (QMS) help ensure compliance, record management, and quality assurance. Listen to the episode
985: The Four Types of Memory Every AI Agent Needs, with Richmond Alake
Oracle’s Director of AI Developer Experience Richmond Alake returns to the show to talk to Jon Krohn about agent memory; the network of systems, models, databases and LLMs that enable AI agents to learn and adapt over time. Listen to the ep
984: Building AI Agents Where 99.9% Accuracy Isn't Good Enough, with Raju Malhotra
Raju Malhotra, Chief Product and Technology Officer at Certinia, talks to Jon Krohn about the so-called SaaSpocalypse and how agentic AI is proving the doomsayers wrong. Listen to the episode to hear more about Certinia’s work with Salesfor
983: AI in the Classroom: How a Top Elementary School Is Doing It Right, with Principal Traci Walker Griffith
My guest today took a public school that was about to be shut down and turned it into the number one school in Boston, and AI is her latest secret weapon. In a long-overdue episode on AI for supporting children’s education, hear directly fr
982: In Case You Missed It in March 2026
Jon Krohn rounds up March’s interviews in this ICYMI episode. Hear from AI and data science experts across the fields of education and business in this wide-ranging series of clips that take listeners from the Renaissance to the near future
981: How Data Engineers Are “10x’ing” Themselves With Agents, feat. Matt Glickman
Matt Glickman talks to Jon Krohn about co-founding the agentic-platform startup, Genesis Computing, how his experience at Goldman Sachs paved the way for developing AI agents, and where he thinks agentic AI has just as much value as a compa
