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The Startup Ideas Podcast

von Greg Isenberg

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  1. Jack Dorsey's Buzz: The New Hermes Agent?

    I sit down with Vinny for a live tour of Buzz, an open source, agent-native chat app from Block built on an open protocol. Vinny makes the case that openness is the real story here: agents arrive as first-class teammates, the harness undern

  2. How I use Claude Code + MCPs to run my marketing

    Cody Schneider is back on the podcast, and I ask him to lay out what a real marketing agent looks like once you get past the hype. He draws a hard line: an agent owns unified business data, runs on a cadence, and improves from the results i

  3. Most Valuable Skill of 2026: Managing AI Agents

    I welcome Ryan Carson back to the show to turn anyone into a world-class agent operator. Ryan spent 25 years founding companies, scaled Treehouse to around 110 employees and a million learners, and now runs Untangle, an AI divorce agent for

  4. FDE: The $1M/Year AI Job Explained

    I sit down with Vas from Varick Agents to map out exactly how to break into AI forward deployed engineering — and how to grow into a sharper FDE — in thirty days. We start from a single premise: every company can now buy the same frontier i

  5. The $1,000/hour Solo AI business (Full Course)

    In this episode I sit down with Corey Ganim to unpack what he calls the simplest way to earn money with AI in 2026: a $999 AI Tools Assessment for small business owners. Corey lays out his entire four-phase system, from a probing discovery

  6. Making $$$ with Loop Engineering

    I sit down with Elie Steinbock to unpack loop engineering and how to run a business on loops. We start with the roots of the idea in the lean startup and Toyota's manufacturing, then move into practical, copy-ready workflows for SEO, Facebo

  7. Grok 4.5 is a bigger deal than Fable

    In this episode I bring Nick Vasilescu, co-founder of Orgo, back on the show to unpack the buzz around Grok 4.5. Nick makes the case for treating Grok 4.5 as a genuine AI co-founder inside harnesses like Hermes and OpenClaw, and he proves i

  8. We Tested OpenAI's GPT 5.6 for a Month

    In this episode I sit down with Dan Shipper to see how he runs his work and personal life on OpenAI's Codex Desktop with the 5.6 model. He walks through his card-based email setup, daily feeds for his company and Slack, and the in-app brows

  9. AI Agents are the new SaaS

    In this solo episode I lay out why I believe building agents is the new SaaS: software is shifting from helping you do the work to doing the work with you. I walk through a full playbook — find a niche, pick a workflow with a paycheck attac

  10. “Learn AI” Is Bad Advice. Learn These Instead

    In this solo episode, I lay out the six skills I believe stay valuable as AI grows more capable. I chose these six because each one is open to anyone, each one starts this weekend, and each one rises in value as AI improves. I walk through

  11. GLM 5.2 Clearly Explained (and how to set it up)

    In this episode I sit down with Amir to get tactical about running local AI models as part of a daily workflow. We center on GLM 5.2 from ZAI, how it stacks up against frontier models like Opus 4.8, and how a fusion approach lets you sequen

  12. Making $$$ with IOS apps

    In this episode I sit down with George Lampropoulos, a 19-year-old founder who turns AI-built mobile apps into real revenue. George walks through his framework for reaching $10K a month—roughly $333 a day—starting with a simple, sellable id

  13. Claude Fable 5 is BANNED. What to do?

    In this solo episode, I walk through the implications of the ban of Claude Fable 5 — the most powerful model on the planet and the one I planned to build with — after the US government sent Anthropic a letter. I make the case for local AI b

  14. You are using Claude Fable 5 wrong

    Get my Fable 5 prompt pack: https://startup-ideas-pod.link/fable5-prompt-pack In this episode I break down how to get the most out of Fable 5, the most powerful model I've ever used. I move past the benchmarks and go straight into tactical

  15. What are Agentic Loops?

    S/o Coderabbit for sponsoring today’s vid: https://startup-ideas-pod.link/code-rabbit On this episode I sit down with Professor Ras Mic to break down agentic loops. We define what a loop is, explain why well-known builders like Boris and Pe

  16. Become AI Native in less than 60 mins

    Become an AI Native Organization: https://startup-ideas-pod.link/ai-native-org In this episode I sit down with Theo to unpack what becoming AI native truly means. We define an AI native org as people managing agents, agents reading and writ

  17. Hermes Agent App Clearly Explained (and how to use it)

    In this episode, I sit down with Alex Finn for a full, screen-shared walkthrough of Hermes Desktop, the new desktop home for the Hermes AI agent. I open with a clear challenge: by the end, sell me on installing Hermes Desktop, show me real

  18. Codex Sites Clearly Explained (and how to use it)

    In this solo episode I walk through Codex Sites end to end, building a real internal tool live so you can copy the exact workflow. I open by comparing Codex Sites with one-prompt tools like Replit and Lovable, then construct a Startup Ideas

  19. The Next $100B Market: Selling To AI Agents

    In this solo episode, I break down the shift from a human-first internet to an agent-first one, where AI agents become the customers that discover, evaluate, pay, and recommend. I map the agent buying journey and the new infrastructure agen

  20. Google's Biggest AI Announcements (I Was There)

    Live from Google I/O, I sit down with Logan Kilpatrick from the Google DeepMind team to unpack everything Google just announced and what it means for founders, developers, and anyone trying to build with AI right now. We dig into Gemini 3.5

  21. 9 Huge Startup Opportunities in the AI Boom

    I sit down with my friend Jonathan Courtney, a.k.a. Jicecream, to dig into the 9 biggest startup opportunities I see right now across B2C, AI, mobile, and IRL. We each pick ideas, trade reactions, and pressure-test them live. The conversati

  22. Andrew Wilkinson: AI Agents run my business and life

    If you want more workflows and tactics to build a business with AI, check out this free workshop: https://www.ideabrowser.com/workshop I sit down with Andrew Wilkinson and we go deep on how he's restructured his work, his health, and his fa

  23. The $1M+ Solo AI Agent Business (Full Course)

    Nick agreed to personally set up your Orgo in a 15 min call: https://startup-ideas-pod.link/orgo_ai I sit down with Nick from Orgo to break down exactly how to run a one-person AI agent business that can realistically clear a few million do

  24. 7 tiny AI agent ideas I built with Genspark Claw

    Get started building your tiny AI Agent business with Genspark Claw: https://www.genspark.ai/?utm_source=po&utm_campaign=GregIsenberg In this solo episode, I share seven tiny, cash-flowing startup ideas you can build with AI in just a few p

  25. My AI Design Workflow That Doesn't Ship Slop

    I sit down with Meng To for his second appearance on the pod to dig into design md, Google's newly open-sourced format for capturing the soul of a design and porting it across every medium and tool. Meng walks me through a live demo of how

  26. Hire a team of AI Agents

    I'm joined again by Imran Muthuvappa to walk through how to build your own AI Chief of Staff using a tool called Nebula. Imran shows me how to spin up specialized agents that handle the work a real chief of staff would do — surfacing team b

  27. How to win with AI Agents in 2026

    Limited BONUS: First 1,000 builders get $1,000. Claim yours while supplies lasts.: https://startup-ideas-pod.link/hyperagent I sit down with Howie Liu, co-founder and CEO of Airtable, to talk about the agent economy and the launch of HyperA

  28. Codex clearly explained (and how to use it)

    I sit down with Riley Brown to get a hands-on tour of OpenAI's Codex, which he argues is the most powerful single interface for using AI agents today. Riley walks me through how Codex unifies vibe coding, knowledge work, browser use, comput

  29. ChatGPT Images 2.0 Is Here. I Tested Everything.

    In this solo episode, I walk through ChatGPT Images 2.0 and show exactly how to use it to build creative assets that move a business forward, from brand visual directions to UI mockups to apparel mockups and editorial illustrations. I share

  30. Hermes Agent clearly explained (and how to use it)

    I sit down with Imran Muthuvappa to get a hands-on walkthrough of Hermes Agent, a personal AI agent that ships with built-in memory, 40+ tools, and pre-installed skills out of the box. Imran walks me through why he migrated from OpenClaw, h

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