#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello

Welcome to another wide-ranging "Random Show" episode that I recorded with my close friend Kevin Rose (kevinrose.com) (digg.com)!
This episode is brought to you by:
Qlosi (qlosi.com/tim) prescription eye drop used to treat age-related blurry near vision (presbyopia) in adults: Qlosi.com/Tim (qlosi.com/tim)
David Protein Bars (davidprotein.com/Tim) with 28g of protein, 150 calories, and 0g of sugar: davidprotein.com/Tim (Buy 4 cartons, get the 5th free.)
Eight Sleep Pod Cover 5 (eightsleep.com/tim) sleeping solution for dynamic cooling and heating: EightSleep.com/Tim (eightsleep.com/tim) (use code TIM to get $400 off your very own Pod 5 Ultra)
Coyote the card game​ (coyotegame.com), which I co-created with Exploding Kittens: coyotegame.com
Timestamps:
• [00:00:00] Start.
• [00:00:52] Why Kevin concluded nearly seven months of sobriety, and the 2-2-2 Rule he now follows for alcohol consumption.
• [00:07:12] My recent adventures in accelerated TMS and bioelectric medicine.
• [00:21:09] The tragic death of Nolan Williams and funding future research through the Saisei Foundation.
• [00:24:23] Aphantasia vs. hyperphantasia, and Joshua Waitzkin's ability to "feel" chess.
• [00:33:12] DORAs for sleep and Alzheimer's prevention: Matt Walker, Belsomra, and the terrifying p-tau blood test.
• [00:41:21] Dale Bredesen's kitchen-sink approach to dementia and the ketogenic connection.
• [00:46:22] The rapid pace of AI development: Why your opinion from three months ago is already obsolete.
• [00:49:40] Google's full-stack advantage: TPUs, Gemini 3, and why they were built for this moment.
• [00:52:50] The future of venture capital: Seed rounds shift later as entrepreneurs gain leverage.
• [00:58:05] Kevin's three AI investment buckets: Power, data centers, and bloated companies ripe for automation.
• [01:02:05] Holiday gift ideas and recommended reading.
• [01:17:41] The Way App and meditation with Zen master Henry Shukman.
• [01:21:44] Kevin's AI stack: Nothing earbuds, Sandbar ring, Notion AI, and the NotebookLM podcast hack.
• [01:26:58] Oboe.fyi: The AI learning platform and my investment philosophy.
• [01:32:09] My new girlfriend, the perils of modern dating apps, and building a communication toolkit.
• [01:38:17] Terry Real's relationship wisdom: Why objective reality has no place in an argument.
• [01:47:18] Dog updates: Molly, a new puppy, and Toaster on rapamycin.
• [01:47:58] Parting thoughts and happy holidays.
*
For show notes and past guests on The Tim Ferriss Show (tim.blog/podcast), please visit tim.blog/podcast/?utm_source=podcast&utm_m….
For deals from sponsors of The Tim Ferriss Show (tim.blog/podcast), please visit tim.blog/podcast-sponsors
Sign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday (go.tim.blog/5-bullet-friday-1).
For transcripts of episodes, go to tim.blog/transcripts.
Discover Tim’s books: tim.blog/books.
Follow Tim:
Twitter: twitter.com/tferriss
Instagram: instagram.com/timferriss
YouTube: youtube.com/timferriss
Facebook: facebook.com/timferriss (facebook.com/TimFerriss)
LinkedIn: linkedin.com/in/timferriss
See Privacy Policy at art19.com/privacy and California Privacy Notice at art19.com/privacy#do-not-sell-my-info.