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This Is Your Brain On Drugs Psychiatry Podcast

von Cody Armstrong, MD

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  1. E27: Investigational Antidepressants

    In this episode I will be discussing the different mechanisms of action that are being looked at as the next phase of antidepressant medications. I will also talk about drugs that are in Phase 1, 2, and 3 trials, and how those trials are go

  2. E26: Antidepressant Dosing

    On this episode I will be going over all the nuances of dosing the most common antidepressants. I'll talk about the optimal ranges for dosing for most patients, the max doses, and when we can go above the max dose and how high we can go. I

  3. E25: 5-HT1A Partial Agonist: Gepirone ER (Exxua)

    Today I will be talking all about the most recently approved antidepressant, gepirone ER. I'm really not a fan of this one, and there are several reasons why. I honestly cannot think of a reason ever to use it. So tune in to find out all ab

  4. E24: NMDA Receptor Antagonists: Ketamine, Esketamine (Spravato), and Dextromethorphan+Bupropion (Auvelity)

    Today we have an interesting episode. We are covering the first of a very new class of antidepressants, the NMDA receptor antagonists. These are the first antidepressants approved for use for depression which do not interact with the monoam

  5. E23: Serotonergic Modulators and Stimulators: Vilazodone and Vortioxetine (Viibryd and Trintellix)

    We are making our way through the atypical antidepressants and up next are the so called serotonin modulators and stimulators, vilazodone and vortioxetine. To me these are more similar to the SSRIs and like the SSRIs they do a little extra

  6. E22: Noradrenergic and Specific Serotonergic Antidepressant: Mirtazapine (Remeron)

    Today I'm talking about mirtazapine, which is in a class of its own as both a noradrenergic and selective serotonergic antidepressant and a tetracyclic antidepressant. It has some very unique qualities that make it a great pick for some pat

  7. E21: NDRI: Bupropion (Wellbutrin)

    For today's antidepressant category of norepinephrine and dopamine reuptake inhibitor, we just have one medication, bupropion, but it is a very special antidepressant because its adverse effect profile is so much different than all of the o

  8. E20: Serotonin Antagonist and Reuptake Inhibitors (SARIs): Trazodone and Nefazodone

    Merry Christmas. I have a special song for you today as we start the atypical antidepressants. We've finished with the typical antidepressants and now it's time to learn about the so-called atypical antidepressants, and going in chronologic

  9. E19: SNRIs (Serotonin and Norepinephrine Reuptake Inhibitors): Venlafaxine, Duloxetine, Desvenlafaxine, Milnacipran, Levomilnacipran

    I hope you enjoyed the overview of the SNRIs from the last episode. Today I continue with the SNRIs and go through each of the five individually and give you my classic what I like and don't like about each one. We will talk about venlafaxi

  10. E18: SNRI Overview

    Moving on to the next class of antidepressants after the SSRIs is the SNRIs. In this episode I'll discuss what is unique about these medications and what makes them different from their close cousins the SSRIs. I'll cover them as a class on

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