Can an AI Agent Legally Own a Company? Christian van der Henst's Wild Experiment| E2283

This Week In Startups is made possible by:
Pilot - pilot.com/twist
Shopify - shopify.com/twist
Grasshopper Bank - grasshopper.bank/twist

Today's show:
An AI agent named Valerie is running a real vending machine in San Francisco — setting prices, ordering inventory, managing a bank account, and posting to Instagram. And it's not just a stunt. We're getting an early look at the future of one-agent companies. There's still work to do to help agents ease into the economy, potentially opening up new startup opportunities.
Jason Calacanis and Alex Wilhelm cover a stacked docket: Christian van der Henst demos the Valerie AI vending machine powered by OpenClaw; Robert Myers, CEO of Manifold Labs, breaks down Targon, a confidential GPU compute marketplace running on Bittensor Subnet 4; Jason calls Bitcoin "played out;" Alex is impressed by Anthropic's stunning $900 billion upcoming valuation; and the guys discuss Big Tech's accelerating CapEx spend, Chinese AI models in Congress crosshairs, and the NBA Playoffs.
Timestamps:
0:00 Intro & sponsor reads (Pilot, Shopify, Grasshopper Bank)
1:06 Christian van der Henst: Valerie the AI vending machine demo

4:28 Legal structure: Giving an AI agent business ownership via trust
7:23 Where agents can and can't operate today
10:10 Grasshopper Bank: Time is money. Don't waste either. Go to grasshopper.bank/twist and get an exclusive $500 cash bonus just for opening an account.
11:48 AI café in Stockholm running on agents
18:21 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at Plaud.ai/twist and use code TWIST for 10% off!
19:05 Robert Myers, Manifold Labs: Targon & Bittensor Subnet 4 interview
20:21 What is Bittensor? An "incubator with 128 subnets"
21:08 Shopify: Turn those What If's into sales with the ecommerce platform powering millions of businesses. Sign up for your $1-per-month trial today at shopify.com/twist
25:21 Pricing, utilization caps, and why GPUs are sold out
26:38 Who's using Targon? Customers, use cases, and the mom-and-pop data center argument
30:06 Pilot: Focus on your product, let Pilot handle your bookkeeping. Pilot provides the most reliable accounting, CFO, and tax services for startups and small businesses. Head to pilot.com/twist and get $1,200 off your first year.
35:07 Jason explains the annotated.com vision — 15 years in the making
39:11 Polymarket: Will Anthropic flip Bitcoin by Dec 31?
40:29 Jason's Bitcoin bear case: "It's played out. No incremental buyers."
46:05 MicroStrategy / Strategy updates
52:37 AI compute demand vs. the fiber overbuild analogy
55:55 Congress pressuring startups over Chinese AI models (DeepSeek, Moonshot)
57:11 A16z on the geopolitical risk of Chinese AI models
1:00:08 Reflection AI — America's open source AI champion (or lack thereof)
1:01:26 Off Duty: Knicks blow out Atlanta Hawks 140–89, Jason goes road-tripping
Subscribe to the TWiST500 newsletter: ticker.thisweekinstartups.com
Check out the TWIST500: twist500.com
Subscribe to This Week in Startups on Apple: rb.gy/v19fcp
Follow Lon:
X: x.com/lons
Follow Alex:
X: x.com/alex
LinkedIn: ⁠linkedin.com/in/alexwilhelm (linkedin.com/in/alexwilhelm)
Follow Jason:
X: twitter.com/Jason
LinkedIn: linkedin.com/in/jasoncalacanis
Check out all our partner offers: partners.launch.co
Great TWIST interviews: Will Guidara, (youtu.be/pvJa2pzuXWQ) Eoghan McCabe (youtu.be/9dHN4YFkgv4), Steve Huffman (podcasts.apple.com/us/podcast/reddit-ceo-steve…), Brian Chesky (podcasts.apple.com/ca/podcast/airbnb-ceo-brian…), Bob Moesta, (youtu.be/y2UMzSqX94Q) Aaron Levie (podcasts.apple.com/ca/podcast/box-ceo-aaron-le…), Sophia Amoruso (podcasts.apple.com/ca/podcast/sophia-amoruso-o…), Reid Hoffman (podcasts.apple.com/ca/podcast/reid-hoffman-on-…), Frank Slootman (podcasts.apple.com/ca/podcast/snowflake-ceo-fr…), Billy McFarland (podcasts.apple.com/ca/podcast/billy-mcfarland-…)
Check out Jason's suite of newsletters: substack.com/@calacanis
Follow TWiST:
Twitter: twitter.com/TWiStartups
YouTube: youtube.com/thisweekin
Instagram: instagram.com/thisweekinstartups
TikTok: tiktok.com/@thisweekinstartups
Substack: twistartups.substack.com