
This Week in Startups· Folge 2281
China Kills Meta / Manus Deal (Story Of The Year) | E2281
Dienstag, 28. April 2026 · 53 min
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Shownotes
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What's the technology story of the year? No, it's not Anthropic's Mythos model, nor any other AI model. Upcoming IPOs? Wrong again. Jason thinks it's China's government's decision to block Meta's acquisition of Manus. The multi-billion-dollar deal was heralded as evidence that AI companies founded in China could sidestep onerous government meddling by moving their operations to Singapore. That loophole now appears closed.
Jason and Lon then dug into the newly-reforged OpenAI-Microsoft partnership. The two companies have had a mutually beneficial, if fractious, operating relationship to date; that they had to rework their agreement is not a shock.
Then, your hosts watched and digested a video from China purportedly showing a self-driving car hitting a child at speed. What would happen in the United States if such a tragedy struck? And is that fait accompli?
Closing the show, Jason and Lon reacted to the latest Russell Brand implosion, discussed Lon's new favorite show 'Criminal Record,' and shared recommended foot pedals (for AI dictation) and headphones for the road warriors tuning in.
Key Links: OpenAI and Microsoft
OpenAI's announcement of its new Microsoft deal (openai.com/index/next-phase-of-microsoft-partn…)
Microsoft's announcement of its new OpenAI deal (blogs.microsoft.com/blog/2026/04/27/the-next-p…)
OpenAI announces its deal with AWS (openai.com/index/introducing-the-stateful-runt…)
News that Microsoft was considering legal action against OpenAI (ft.com/content/e814f4c3-4fb5-4e2e-90a6-4700444…)
Microsoft-OpenAI negotiations late 2025 edition (blogs.microsoft.com/blog/2025/10/28/the-next-c…), and terms announced in early 2026 (blogs.microsoft.com/blog/2026/02/27/microsoft-…)
Amazon announces that OpenAI models are coming to AWS (reuters.com/legal/litigation/microsoft-end-exc…)
Timestamps:
Show starts
OpenAI and Microsoft have a new deal
Why would Microsoft cede exclusive access to OpenAI models?
Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at Plaud.ai/twist and use code TWIST for 10% off!
Why Jason thinks Microsoft and Apple should work together on AI
China will block the Meta-Manus deal
Deel - Founders scale faster on Deel. Set up payroll for any country in minutes, hire anyone anywhere, get visas handled fast, and get back to building. Visit deel.com/twist to learn more.
Golden Shares and what they provide
How do you unravel a multi-billion-dollar deal?
Sentry - New users can get $240 in free credits when they go to sentry.io/twist and use the code TWIST
The Huawei ADC crash
What happens when something similar happens in the United States?
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Russell Brand's public humiliation
Don't trust palm reading!
Lon's Off Duty streaming pick: Criminal Record
Jason's Pick: Which foot pedal for AI dictation is right for you?
Jason's Pick: In the market for new headphones?
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