TWiV 1357: Furin, Naturally with Paul Bieniasz

Paul Bieniasz joins TWiV to discuss his lab’s discovery that the coronavirus nuclease NSP15 cuts viral RNA into oligonucleotides that are reinserted elsewhere in the viral RNA, generating insertion mutations at a frequency above 10⁻³ per genome, including new furin cleavage sites at the spike S1/S2 junction.
Hosts: Vincent Racaniello (en.wikipedia.org/wiki/Vincent_Racaniello), Alan Dove (turbidplaque.com), and Kathy Spindler Guest: Paul Bieniasz Subscribe (free): Apple Podcasts, RSS, email (eepurl.com/Gcw59)
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Links for this episode • Support science education (microbe.tv/contribute)at MicrobeTV
• Genetic innovation in coronaviruses driven by a viral nuclease (bioRxiv)
• Letters read (microbe.tv/twiv/twiv-1357-letters)on TWiV 1357
• Timestamps by Jolene Ramsey. Thanks!
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Listener Pick Shirley – I Told You So! by Matt Kaplan
Intro music is by Ronald Jenkees
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