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The AI Pioneer Developing New Kinds of Medicine
Jakob Uszkoreit is the CEO and co-founder of Inceptive, a biotech start-up. He’s also a co-author of “Attention is All You Need,” the paper that created transformer models. Today, transformers power chatbots like ChatGPT and Claude. They’ve
A Billion-Dollar Bet on Carbon Removal
Nan Ransohoff is the head of climate at Stripe. The company is known mainly for facilitating online payments, but it’s become a key driver of the nascent carbon-removal industry. On today’s show, Nan explains how she used a clever economic
Giving Old Batteries New Life
Megan O’Connor is the co-founder and CEO of Nth Cycle. Megan’s problem is this: How do you create a new system that can both refine the raw metals we need for new batteries and recycle metal from old batteries? See https://omnystudio.com/li
Engineering the Future of Fusion
Getting energy from nuclear fusion has been a dream for decades; it would be cheap, abundant, and safer than today’s nuclear fission reactors. Billions of dollars have flowed into fusion startups in recent years, but reliable, economic fusi
Can Robots Fix Recycling?
Recycling plants take in a huge amount of random (and occasionally hazardous) stuff, which they then have to turn into reliable outputs that their customers will buy. That’s why Rebecca Hu Thrams calls recycling “the most demented form of m
Inside the Mind of an AI Model
AI might be the most consequential advancement in the world right now. But – astonishingly – no one fully understands what’s going on inside AI models. Josh Batson is a research scientist at Anthropic, the AI company behind Claude, one of t
Teaching Robots How to Do Everything
AI is better than humans at a lot of things, but physical tasks – even seemingly simple ones like folding a shirt – routinely stump AI-powered robots. Chelsea Finn is a professor at Stanford and the co-founder of Physical Intelligence. Chel
Making a Universal Flu Vaccine
Jacob Glanville is the founder and CEO of Centivax. Jacob’s problem is this: Can you create a vaccine that protects people against almost all strains of flu – even strains that haven’t evolved yet? Get early, ad-free access to episodes of W
Teaching Computers to Smell
Alex Wiltschko got obsessed with perfume when he was 12 years old. He grew up to be an AI researcher at Google. Then he started Osmo, a company that fused his job at Google with his childhood obsession: Osmo is using AI to teach computers t
Can a Chatbot Treat Depression?
Nick Jacobson and his team at Dartmouth medical school spent over 100,000 hours trying to build an AI chatbot that can serve as a safe, effective therapist. After a few false starts, they seem to be on to something. Note: This episode conta
Will AI Radically Change the World by 2027?... from Risky Business
This week, Nate and Maria discuss AI 2027, a new report from the AI Futures Project that lays out some pretty doom-y scenarios for our near-term AI future. They talk about how likely humans are to be misled by rogue AI, and whether current
Is the Future of Flight Supersonic?
Blake Scholl is the founder and CEO of Boom Supersonic. Blake's problem is this: Can you build a commercial airplane that flies faster than the speed of sound – and that makes economic sense? Get early, ad-free access to episodes of What's
The Secrets of Silk
Fiorenzo Omenetto is a professor of biomedical engineering at Tufts University and the director of Silklab. Fiorenzo's problem is this: How do you turn a material people have been using for thousands of years into useful, cutting edge tools
Infiltrating an International Ransomware Gang
A few years ago, a ransomware gang called LockBit rose from obscurity to extort over $100 million from organizations around the world. A security strategist named Jon DiMaggio wanted to understand how the organization worked. So he used the
Preparing for the Future of War
Christopher Kirchhoff helped launch a Defense Department office that aimed to bring Silicon Valley technology to the US military. Christopher’s problem is this: How can the giant bureaucracy that is the US military keep up with technologica
Stopping HIV Without a Vaccine
Jared Baeten is senior vice president in virology at Gilead Sciences. Jared's problem is this: In a world without a vaccine, how do you make a medicine that people will actually take to help prevent HIV? There’s already a daily pill that re
Harnessing the Heat Deep Beneath Our Feet
Carlos Araque is the co-founder and CEO of Quaise Energy. Carlos' problem is this: How do you make drilling for geothermal energy as routine, widespread, and profitable as drilling for oil or gas? The answer involves digging deeper into the
The Brain Implant That Could Change Medicine
Ben Rapoport is the co-founder and CSO of Precision Neuroscience. Ben's problem is this: Can you build a device that allows a paralyzed person to use a computer with only their thoughts – without damaging their brain? See https://omnystudio
Building a Mass Market Robot
Jeff Cardenas is the co-founder and CEO of Apptronik. Jeff's problem is this: Can you make a safe, reliable humanoid robot – for less than $50,000? In the short term, Apptronik’s robots will work in factories. But Jeff’s long-term goal – ba
Solving Solar’s Biggest Problem
We need better, cheaper ways to store solar and wind energy when it’s dark out and the wind isn’t blowing. One option: Compressing air in underground caverns when energy is abundant, then blowing it back out to create energy when you need i
How Bubbles Power Breakthroughs
There are moments in history when people make huge technological advances all of a sudden. Think of the Manhattan Project, the Apollo missions, or, more recently, generative AI. But what do these moments have in common? Is there some set of
Teaching AI to Build Stuff in the Physical World
AI works well in the virtual world. That’s partly because the internet provides so much data to train AI models. But there’s no analogous data set for the physical world – and as a result, AI doesn’t work as well there… yet. Edward Mehr is
NVIDIA: At the Heart of the AI Boom
In the past few years, NVIDIA has become one of the most valuable and important companies in the world by making GPUs, the chips powering the AI boom. But where did the company come from, and why are NVIDIA chips the ones that dominate AI?
What Claude Shannon Figured Out
Claude Shannon is a major figure in the history of technology. Known as the father of information theory, Shannon spent decades at Bell Labs and MIT. But what exactly did Claude Shannon figure out, and why is it so important? To answer that
Measles: The Cancer Killer?... from Incubation
We thought we knew everything there was to know about measles. But in recent years, new research has revealed that the virus attacks the immune system and creates effects far more dramatic than a rash and fever. For this episode we’re joine
RoboPod and the Perpetual Money Machine – Cautionary Questions 2… from Cautionary Tales
What really drove the 2008 financial crash? What’s a shadow bank? And what’s the connection between NIMBYs and BANANAs? Tim Harford and Jacob Goldstein answer more of your questions. Enjoy this episode from Cautionary Tales (https://www.pus
Turning Solar Energy Into Fuel (The Solar Era, Part 3)
Solar power and batteries are becoming cheap and ubiquitous. Great. But there are problems batteries can’t solve – like fueling ships and planes. One way to solve those problems: Use solar power to create hydrogen, and turn that hydrogen in
Can Hot Bricks Save the World? (The Solar Era, Part 2)
This is the second of three episodes about the solar-power revolution. Last week, we talked about how solar power got so cheap. This week, we’re talking with someone who is building giant plants around the world to take advantage of all tha
How the Sun Won (The Solar Era, Part 1)
In the past 20 years, the price of solar panels has fallen by more than 97 percent. This extraordinary decline is good news for the world – and it’s transforming the way energy is produced and consumed. For the next few episodes, we’ll be t
Drugs in Space
Paul Reichert is a research scientist at Merck, working on improvements to how we administer drugs to patients. Paul's problem is this: How can you run experiments in space to learn how to make better drugs on Earth? See https://omnystudio.
