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Every week on What's Your Problem?, former Planet Money host Jacob Goldstein talks with entrepreneurs and engineers tackling the biggest challenges at the forefront of technology. How do you make a trip to space as routine as a plane flight? How do you turn solar energy into clean fuel? How do you use AI to stop deadly infections before they spread? We hear a lot these days about how the world is getting worse. What's Your Problem? learns from the thinkers and doers trying to make our future better.
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Can a Cancer Gene Keep Muscles Young?
Kevin Murach is a professor who studies muscle cells at the University of Missouri. Kevin's problem is this: Can we understand what's going on in our cells when we lift weights – and can we use that knowledge to help people stay healthier a
How Warren Buffet Built His Legacy By Finding Value No One Else Could See from Business History
Throughout the next few weeks, every Monday we'll be sharing some of our favorite episodes from Jacob's other show Business History. We hope you enjoy them and if you want to hear more, subscriber to Business History on Apple (https://podca
Every Cell in Your Body Has a Clock
Circadian rhythm isn’t just controlled by your brain. Every cell in your body runs on a 24-hour cycle, including your muscle cells. Karyn Esser is the chair of the department of physiology and aging at the University of Florida, and she’s a
How a Bad Boss Kickstarted Silicon Valley... from Business History
Throughout the next few weeks, every Monday we'll be sharing some of our favorite episodes from Jacob's other show Business History. We hope you enjoy them and if you want to hear more, subscriber to Business History on Apple (https://podca
Solving the Trust Problem in AI Shopping
Note: Today’s show is sponsored by PayPal. Kartik Hosanagar is a professor at the Wharton School. The problems he studies include: What will it take for people to trust AI agents to buy stuff for them? And how should businesses prepare for
Can a Robot Build Better, Cheaper Houses?
Jason Ballard is the co-founder and CEO of ICON. Jason's problem is this: Can you use 3-D printing to build houses that are cheaper, better and more interesting than the houses we build now? In this episode, Jason explains: • Why constructi
Did AI Write This?
Celebrated novelists, countless students and at least one billionaire have recently been accused of using AI in their writing. The most commonly cited AI detector in these cases is called Pangram. Max Spero is the co-founder and CEO of Pang
Blockers | A Preview of Michael Lewis's New Audiobook
I'm here with a preview of Blockers, a new audiobook from Michael Lewis, the author of Liars Poker, Moneyball, The Big Short and more. In Blockers, Lewis tells the story of a handful of people who dedicated their careers to public service—u
Can We Defeat Deepfakes?
We’ve all heard that nothing ever gets deleted from the internet. Luke Arrigoni says that just isn’t true. His company deletes thousands of deepfakes every day. Luke is the founder and CEO of Loti, and his problem is this: How do you turn t
The Printing Press: The Invention Built on Debt and Sin… from Business History
Before 1450, books were written out by hand. It was slow and expensive. But Johannes Gutenberg borrowed a ton of money to create a printing press that could crank out Bibles and pamphlets and documents in huge numbers. Science, politics and
Should We Pause AI?
Everybody’s worried about the risks of AI. So we called up one of the most insightful writers we know on the subject: Zvi Mowshowitz. Zvi writes about AI and AI risks at his substack, Don’t Worry About the Vase (https://thezvi.substack.com/
Bonus: Planning for Your Financial Future
On this bonus episode of What’s Your Problem, Jacob talks to Christine Chase, a Vice President, Financial Consultant at Fidelity Investments. Christine’s problem is this: How do you help clients build a plan to achieve their financial goals
Can a Robot Kill Fish Humanely?
The fish we eat usually die slowly, suffocating after they’re pulled out of the water. Saif Khawaja is the co-founder and CEO of a company called Shinkei. Saif's problem is this: Can he build a machine to efficiently kill fish in a way that
Using Satellites to Prevent Famines
Catherine Nakalembe is an assistant professor at the University of Maryland and the head of the Africa program at NASA Harvest, which uses satellite images to track agriculture around the world. Catherine’s problem is this: How do you predi
The Quantum Shift in Biomedical Discovery from Smart Talks with IBM
When Dr. Lara Jehi began treating epilepsy patients in the 2000s, critical surgical decisions were driven more by clinician intuition and expertise than data. Today, she is a leader of IBM and Cleveland Clinic’s Discovery Accelerator, using
Can We Slow Down Aging?
Nir Barzilai is a physician and a researcher at the Albert Einstein College of Medicine in New York, where he runs the Institute for Geroscience. Nir’s problem is this: How can we use lifestyle changes and drugs to slow the process of aging
Why Doctors Use Evidence but Managers (Mostly) Don’t
Helen Pearson is the author of the book “Beyond Belief: How Evidence Shows What Really Works.” Helen's problem is this: How do you get people to make important decisions based on high-quality evidence, instead of on hunches or habits? In th
The Job AI Was Supposed to Kill
In 2016, Geoffrey Hinton, one of the inventors of modern AI, predicted that AI would replace radiologists within years. Ten years later, we have a shortage of radiologists. AI has yet to revolutionize the field. What happened, and what does
How China Won the Car Industry
After spending decades as marginal players in the global auto industry, Chinese carmakers have become the world’s biggest exporters of cars. Chinese cars are some of the best cars on the planet, and they’re available almost everywhere – exc
Using Viruses to Fight Disease
Phages are viruses that attack bacteria. People have been using phages to treat infections for over a hundred years, but in most cases they just don't work as well as antibiotics. Paul Garofolo is the co-founder and CEO of Locus Biosciences
How AI Could Reduce Inequality
David Autor is a labor economist at MIT. He has written about how the arrival of personal computers increased inequality among American workers. But when it comes to AI, David thinks there could be a different outcome. Read David’s article
Racing Wildfires to Warn the Public
John Mills is the CEO and co-founder of a nonprofit called Watch Duty. His problem is this: How do you build an app to warn people when they are in immediate danger from a natural disaster? Watch Duty has millions of users and played a key
How AI Could Actually Make the World Better
Josh Tyrangiel is the author of “AI for Good: How Real People Are Using Artificial Intelligence to Fix Things That Matter (https://www.simonandschuster.com/books/AI-for-Good/Josh-Tyrangiel/9781668082508).” On today’s show, Josh talks about
Finding Meaning (and Money) in the AI Age
Betsey Stevenson is a labor economist at the University of Michigan, and she was an economic adviser to President Obama. Betsey’s problem is this: How can we create a world where the benefits of AI are broadly shared? Betsey draws on histor
Using Pokémon Go to Map the World
Maps have gotten much better over the past few decades. But they're still mostly two dimensional, and they struggle to keep up with a world that is always changing. Brian McClendon is the Chief Technology Officer of Niantic Spatial, a spino
The Company Where Everyone Has Their Own AI Agent
Dan Shipper is the co-founder and CEO of Every, a company that publishes newsletters about AI, develops AI-related software, and helps other companies use AI. Dan has two problems. One, how do you build a company where almost everybody has
Inventing a Better Apple
The apples you can buy at the grocery store have gotten profoundly better over the past few decades. It’s a kind of everyday, hiding-in-plain sight innovation. Kate Evans is an apple breeder and professor at Washington State University. Kat
Building a Business on the Moon
Rob Meyerson is the co-founder and CEO of Interlune. Rob's problem is this: How do you help build an economy on the moon? Eventually, Rob hopes Interlune will help build a moon base. For now, he is focused on bringing a gas called helium-3
Building a Robot People Actually Want
Aaron Edsinger left his job as director of robotics at Google to start a company called Hello Robot. Aaron’s problem is this: How do you build an affordable robot that people can use to solve real problems at home? The result is a robot tha
Turning Waste Wood Into Buildings
Ben Christensen is the co-founder and CEO of Cambium, the largest seller of salvaged wood in America. Ben's problem is this: How can we turn the trees that are falling to the ground all around us, into usable wood? In this episode, Ben expl
