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The Great Fusion Debate: How Far Away Are We Really?
Investors are pouring billions of dollars into nuclear fusion companies. The dream: transform human civilization (and power AI data centers) by providing cheap, abundant energy. But nobody’s figured out how to make it work yet. What will it
How SharkNinja Keeps Going Viral
Mark Barrocas is the CEO of SharkNinja, a company that sells everything from vacuums, to blenders, to beauty products. Mark’s problem is this: How do you invent new products that people want to rave about on social media? In this episode, M
Growing New Livers to Save Lives
Michael Hufford is the co-founder and CEO of LyGenesis, a company working on a new treatment for end stage liver disease. Michael’s problem is this: How do grow a new liver inside the body of a sick patient? In this episode, Michael explain
Can the US Break China's Grip on Rare Earths?
Rare earth elements are inside pretty much everything with an on-off switch: Phones, laptops, cars. Even missiles. And China controls the world’s supply of components made from rare earths. David Abraham is the author of the book “The Eleme
How Quantum Computers Could Change the World
Ben Bloom is the co-founder and CEO of Atom Computing, a company building quantum computers out of individual atoms. Ben’s problem is this: How do you build a quantum computer that is actually useful for everything from discovering new medi
Fighting Wildfires from Space
Jonny Dyer is the founder and CEO of a satellite company called Muon Space (https://www.muonspace.com/). The company’s first big project is a satellite constellation called FireSat. Jonny’s problem is this: How do you capture data from spac
The Killer We Refused to See
After bacteria were discovered, it took scientists 200 years to figure out that they cause disease. If scientists had made the link sooner, hundreds of millions of lives could have been saved. In his recent book So Very Small, Tom Levenson,
The Startup Run by AI Agents
Evan Ratliff co-founded a publishing startup in 2011. Now he hosts a podcast called Shell Game. In the latest season of the show, Evan creates a company run by AI agents. The project is absurdly funny – Evan calls it an office satire – but
Can AI Help Solve Alzheimer’s?
Patrick Hsu is the co-founder of Arc Institute, which is integrating AI models and biological research. Patrick’s problem is this: How can you use AI to make biological research more efficient – and ultimately to find cures for Alzheimer’s
The New Science of Preventing Heart Attacks
In recent decades, medical research has fundamentally changed how we think about heart disease. This fresh understanding has opened up new ways to prevent heart attacks. Eric Topol is a cardiologist and the founder of the Scripps Research T
From Solar Pumps to Everything: Building a Market from Scratch
Samir Ibrahim is the co-founder and CEO of SunCulture. When he started the company, he thought he was solving a simple problem: How do you sell solar-powered pumps to help poor farmers irrigate their land? It turned out, he was working on s
Mass-Producing Stem Cells to Cure Disease
Nabiha Saklayen is the co-founder and CEO of Cellino. Nabiha’s problem is this: How can you make personalized stem cell therapies quickly and cheaply? Induced pluripotent stem cells, or IPSCs, have shown tremendous promise as treatments for
Building a Self-Driving Tractor to Change the Future of Food
Please take our survey https://tinyurl.com/wyplistenersurvey about the show! Tell us what you want to hear, and what would make it better. Tim Bucher is a farmer, and the founder and CEO of Agtonomy. Tim's problem is this: How do you build
We’re Going to Need a Better Boat
Mitch Lee is the co-founder and CEO of Arc Boats. Mitch's problem is this: How do you build competitively priced electric boats? On today’s show, Mitch explains why water makes electrification so hard, the techno-economic puzzle of building
The App Where Strangers Lend Each Other Money
Nina Mohanty is the founder and CEO of Bloom Money. Nina’s problem is this: How do you build an app to help immigrants manage their money? On today’s show, Nina talks about bringing a saving and lending practice into the 21st century, navig
Introducing Business History: The Edison Invention People Don't Talk About
What's Your Problem? host Jacob Goldstein has a new show: Business History (https://apple.co/4nuRrLg). How did Hitler’s favorite car become synonymous with hippies? What got Thomas Edison tangled up with the electric chair? Did someone murd
Using Sound Waves to Destroy Tumors
Mike Blue is the CEO of HistoSonics. The company recently developed a device that uses ultrasound to destroy tumors. On today’s show, Mike talks about how a garage-built prototype became an FDA-approved machine; changing the company’s story
From Desert Robots to Driverless Trucks
Chris Urmson is the co-founder and CEO of Aurora, a company trying to bring autonomous driving to commercial trucking. Chris led a team at the 2004 DARPA challenge that launched the autonomous vehicle industry. Then he held a senior role at
Is the Future of Fresh Water Under the Sea?
Michael Porter is the Chief Technology Officer of OceanWell. Michael's problem is this: How can you desalinate water at the bottom of the ocean – and deliver it to land at a cost that’s competitive with other sources of fresh water? On toda
Could Home Batteries Save the Grid?
Justin Lopas is the COO and co-founder of Base Power, a battery and power company based in Texas. Justin’s problem is this: How can you deliver more energy to more people without having to build so much more grid? On today’s show, Justin ex
Building a Better Public Bathroom
Fletcher Wilson is the CEO and co-founder of Throne Labs. Fletcher’s problem is this: How can you create public toilets that people actually want to use? On today’s show, Fletcher explains how his company is trying to make public bathrooms
Could Autonomous Diggers Unleash a Building Boom?
Boris Sofman is the co-founder and CEO of Bedrock Robotics. Boris' problem is this: How do you teach machines not just to drive, but also to work: to grade roads, move heavy objects and dig big holes at construction sites. On today’s show,
Growing Meat from Cells
Justin Kolbeck is the co-founder and CEO of Wildtype, a company making seafood without killing fish. Their first product is cultivated salmon, which is made from real salmon cells that are grown in a stainless steel vat. Justin's problem is
The Ordinary Stuff Behind Technological Breakthroughs
Ed Conway is an economics journalist and author of the book “Material World: The Six Raw Materials that Shape Modern Civilization.” On today’s show, Ed reveals how three of those often-overlooked materials—iron, copper, and sand—shaped huma
Carbon Capture at Rock-Bottom Prices
Shashank Samala is the CEO and co-founder of Heirloom, a carbon capture start-up. His problem is this: Can you use crushed up rocks to permanently suck carbon out of the atmosphere? And can you do it cheaply enough to have a global impact?
Why Amazon Built a Spatula-Wielding Robot
Aaron Parness is a director of applied science at Amazon Robotics. His problem is this: How do you build a robot that can put stuff on shelves. Today on the show, Aaron explains why this is a surprisingly hard problem – and why the solution
Drilling Smarter Wells to Unleash Geothermal Energy
In many places on Earth, there’s steam just below the surface. We don’t know where those places are — but if we could figure it out, we could unlock a lot of clean energy. Carl Hoiland is the co-founder and CEO of Zanskar, a geothermal ener
Inventing a Better Pain Pill
Dr. Stephen Waxman is a professor of neurology, neuroscience and pharmacology at Yale. His research on pain helped pave the way for a newly approved, non-addictive pain drug called suzetrigine. On today’s show, he explains why he thinks suz
Mapping the Unmappable
Philipp Kandal is the chief product officer of Grab, an app that serves several countries across Southeast Asia. Two of Grab’s main businesses are delivery and mobility – like a combination between Instacart and Uber. And maps are at the co
Reinventing Blood
Dr. Allan Doctor is the co-founder and chief scientific officer at Kalocyte, a company that is developing dried red blood cells that can be rehydrated and used in medical emergencies. On today’s show, Dr. Doctor explains the complex science
