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  1. Physical AI that Moves the World — Qasar Younis & Peter Ludwig, Applied Intuition

    <p>From building Applied Intuition from YC-era autonomy tooling into a $15B physical AI company, Qasar Younis and Peter Ludwig have spent the last decade living through the full arc of autonomy: from simulation and data infrastructure for r

  2. AIE Europe Debrief + Agent Labs Thesis: Unsupervised Learning x Latent Space Crossover Special (2026)

    <p>Today, we check in a year after the first Unsupervised Learning x Latent Space Crossover special to discuss everything that has changed (there is a lot) in the world of AI. This episode was recorded just after AIE Europe, but before the

  3. Shopify’s AI Phase Transition: 2026 Usage Explosion, Unlimited Opus-4.6 Token Budget, Tangle, Tangent, SimGym — with Mikhail Parakhin, Shopify CTO

    <p>Early bird discounts for the San Francisco World’s Fair, the biggest AIE gathering of the year, end today - prices will go up by ~$500 tonight so do please lock in ASAP! From near-universal AI tool adoption inside Shopify to internal sys

  4. 🔬 Training Transformers to solve 95% failure rate of Cancer Trials — Ron Alfa & Daniel Bear, Noetik

    <p>Today, we explain this piece of “clickbait” from our guest! TL;DR: 95% of cancer treatments fail to pass clinical trials, but it may be a matching problem — if we better understood what patients have which tumors which will respond to wh

  5. ⚡️ How to turn Documents into Knowledge: Graphs in Modern AI — Emil Eifrem, CEO Neo4J

    <p>Watch the full show on YouTube: https://www.youtube.com/watch?v=yyuVR-ML9X8</p><p><a href="https://www.youtube.com/watch?v=yyuVR-ML9X8">Full show notes and links</a></p>

  6. Notion’s Token Town: 5 Rebuilds, 100+ Tools, MCP vs CLIs and the Software Factory Future — Simon Last & Sarah Sachs of Notion

    <p>For all those who missed out on London, see you in Miami next week! Notion, the knowledge work decacorn, has been building AI tooling since before ChatGPT, with many hits from Q&A in 2023 and unified AI in 2024 and Meeting Notes in 2025.

  7. ⚡️ The best engineers don't write the most code. They delete the most code. — Stay Sassy

    <p>Watch the full show on YouTube: https://www.youtube.com/watch?v=5KnCKadxSPY</p><p><a href="https://www.youtube.com/watch?v=5KnCKadxSPY">Full show notes and links</a></p>

  8. Extreme Harness Engineering for Token Billionaires: 1M LOC, 1B toks/day, 0% human code, 0% human review — Ryan Lopopolo, OpenAI Frontier & Symphony

    <p>We’re proud to release this ahead of Ryan’s keynote at AIE Europe. Hit the bell, get notified when it is live! Attendees: come prepped for Ryan’s AMA with Vibhu after. Move over, context engineering. Now it’s time for Harness engineering

  9. Marc Andreessen introspects on The Death of the Browser, Pi + OpenClaw, and Why "This Time Is Different"

    <p>Fresh off raising a monster $15B, Marc Andreessen has lived through multiple computing platform shifts firsthand, from Mosaic and Netscape to cofounding A16z. In this episode, Marc joins swyx and Alessio in a16z’s legendary Sand Hill Roa

  10. Moonlake: Causal World Models should be Multimodal, Interactive, and Efficient — with Chris Manning and Fan-yun Sun

    <p>We’ve been on a bit of a mini World Models series over the last quarter: from introducing the topic with Yi Tay, to exploring Marble with World Labs’ Fei-Fei Li and Justin Johnson, to previewing World Models learned from massive gaming d

  11. Mistral: Voxtral TTS, Forge, Leanstral, & what's next for Mistral 4 — w/ Pavan Kumar Reddy & Guillaume Lample

    <p>Mistral has been on an absolute tear - with frequent successful model launches it is easy to forget that they raised the largest European AI round in history last year. We were long overdue for a Mistral episode, and we were very fortuna

  12. 🔬 Why There Is No "AlphaFold for Materials" — AI for Materials Discovery with Heather Kulik

    <p>Materials science is the unsung hero of the science world. Behind every physical product you interact was decades of research into getting the properties of materials just right. Your gym clothes contain synthetic fibers developed over d

  13. Dreamer: the Personal Agent OS — David Singleton

    <p>Mar 23 update for Latent Spacenauts: this episode was recorded before the Dreamer team announced they were joining Meta Superintelligence Labs, and it turned out to be the last interview they did before the news became public. Consider t

  14. Why Anthropic Thinks AI Should Have Its Own Computer — Felix Rieseberg of Claude Cowork & Claude Code Desktop

    <p>Claude Cowork came out of an accident. Felix and the Anthropic team noticed something interesting with Claude Code: many users were using it primarily for all kinds of messy knowledge work instead of coding. Even technical builders would

  15. ⚡️ Monty: the ultrafast Python interpreter by Agents for Agents — Samuel Colvin, Pydantic

    <p>Watch the full show on YouTube: https://www.youtube.com/watch?v=nxnQl4AcqFg</p><p><a href="https://www.youtube.com/watch?v=nxnQl4AcqFg">Full show notes and links</a></p>

  16. Retrieval After RAG: Hybrid Search, Agents, and Database Design — Simon Hørup Eskildsen of Turbopuffer

    <p>Turbopuffer came out of a reading app. In 2022, Simon was helping his friends at Readwise scale their infra for a highly requested feature: article recommendations and semantic search. Readwise was paying ~$5k/month for their relational

  17. NVIDIA's AI Engineers: Agent Inference at Planetary Scale and "Speed of Light" — Nader Khalil (Brev), Kyle Kranen (Dynamo)

    <p>Join Kyle, Nader, Vibhu, and swyx live at NVIDIA GTC next week! Now that AIE Europe tix are ~sold out, our attention turns to Miami and World’s Fair! The definitive AI Accelerator chip company has more than 10xed this AI Summer: And is n

  18. ⚡️ OpenClaw's Memory Sucks and the fix is simple — Dhravya Shah, Supermemory

    <p>Watch the full show on YouTube: https://www.youtube.com/watch?v=Io0mAsHkiRY</p><p><a href="https://www.youtube.com/watch?v=Io0mAsHkiRY">Full show notes and links</a></p>

  19. Cursor's Third Era: Cloud Agents

    <p>All speakers are announced at AIE EU, schedule coming soon. Join us there or in Miami with the renowned organizers of React Miami! Singapore CFP also open! We’ve called this out a few times over in AINews, but the overwhelming consensus

  20. Every Agent Needs a Box — Aaron Levie, Box

    <p>The reception to our recent post on Code Reviews has been strong. Catch up! Amid a maelstrom of discussion on whether or not AI is killing SaaS, one of the top publicly listed SaaS companies in the world has just reported record revenues

  21. ⚡️ Polsia: Solo Founder Tiny Team from 0 to 1m ARR in 1 month & the future of Self-Running Companies

    <p>Watch the full show on YouTube: https://www.youtube.com/watch?v=Yw-m0PI2Atk</p><p><a href="https://www.youtube.com/watch?v=Yw-m0PI2Atk">Full show notes and links</a></p>

  22. METR’s Joel Becker on exponential Time Horizon Evals, Threat Models, and the Limits of AI Productivity

    <p>This is a free preview of a paid episode. To hear more, visit www.latent.space AIE Europe CFP and AIE World’s Fair paper submissions for CAIS peer review are due TODAY - do not delay! Last call ever. We’re excited to welcome METR for the

  23. [LIVE] Anthropic Distillation & How Models Cheat (SWE-Bench Dead) | Nathan Lambert & Sebastian Raschka

    <p>Swyx joined SAIL! Thank you SAIL Media, Prof. Tom Yeh, 8Lee, Hamid Bagheri, c9n, and many others for tuning into SAIL Live #6 with Nathan Lambert and Sebastian Raschka, PhD. Sharing here for the LS paid subscribers. We covered: This is a

  24. 🔬 Searching the Space of All Possible Materials — Prof. Max Welling, CuspAI

    <p>Editor’s note: CuspAI raised a $100m Series A in September and is rumored to have reached a unicorn valuation. They have all-star advisors from Geoff Hinton to Yann Lecun and team of deep domain experts to tackle this next frontier in AI

  25. Claude Code for Finance + The Global Memory Shortage: Doug O'Laughlin, SemiAnalysis

    <p>This is a free preview of a paid episode. To hear more, visit www.latent.space First speakers for AIE Europe and AIEi Miami have been announced. If you’re in Asia/Aus, come by Singapore and Melbourne. AI Engineering is going global! One

  26. ⚡️ The End of SWE-Bench Verified — Mia Glaese & Olivia Watkins, OpenAI Frontier Evals & Human Data

    <p>Olivia Watkins (Frontier Evals team) and Mia Glaese (VP of Research at OpenAI, leading the Codex, human data, and alignment teams) discuss a new blog post (https://openai.com/index/why-we-no-longer-evaluate-swe-bench-verified/) arguing t

  27. Bitter Lessons in Venture vs Growth: Anthropic vs OpenAI, Noam Shazeer, World Labs, Thinking Machines, Cursor, ASIC Economics — Martin Casado & Sarah Wang of a16z

    <p>Tickets for AIEi Miami and AIE Europe are live, with first wave speakers announced! From pioneering software-defined networking to backing many of the most aggressive AI model companies of this cycle, Martin Casado and Sarah Wang sit at

  28. Owning the AI Pareto Frontier — Jeff Dean

    <p>From rewriting Google’s search stack in the early 2000s to reviving sparse trillion-parameter models and co-designing TPUs with frontier ML research, Jeff Dean has quietly shaped nearly every layer of the modern AI stack. As Chief AI Sci

  29. 🔬 Beyond AlphaFold: How Boltz is Open-Sourcing the Future of Drug Discovery

    <p>This podcast features Gabriele Corso and Jeremy Wohlwend, co-founders of Boltz and authors of the Boltz Manifesto, discussing the rapid evolution of structural biology models from AlphaFold to their own open-source suite, Boltz-1 and Bol

  30. ⚡️ Reverse Engineering OpenAI's Training Data — Pratyush Maini, Datology

    <p>Watch the full show on YouTube: https://www.youtube.com/watch?v=CSgjaC6y6Mk</p><p><a href="https://www.youtube.com/watch?v=CSgjaC6y6Mk">Full show notes and links</a></p>

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