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  1. Building a Health System for “Customers” | Baylor Scott & White Health CEO Pete McCanna

    Pete McCanna, CEO of Baylor Scott & White Health, believes that health systems are built around the wrong objective… and he has an ambitious goal to change that. This week, Halle sits down with McCanna to unpack how one of the largest and m

  2. 📣 Digital Health Download: April 2026

    We’re back with our monthly rundown of the top headlines in health tech! Today, Halle flies solo to share the biggest stories that shaped Q1, from the rising pressures on PBMs to how consumers are using AI. Stories covered: • What's happeni

  3. The Drugstore Cowboy | C.O. Bigelow Owner & Pharmacist Alec Ginsberg

    Last year, his independent pharmacy spent $13 million on brand-name drugs for patients processed by the three biggest Pharmacy Benefit Managers (PBMs) which earned a profit margin of 0.01%. In this episode, Halle speaks with Alec Ginsberg,

  4. Where Healthcare Policy Is Headed | Chief Counselor at HHS, Chris Klomp

    Chris Klomp, Director of Medicare and Deputy Administrator of CMS, and Senior Advisor to HHS Secretary RFK Jr., has big ambitions to reshape how healthcare works in the United States. This week, ​​Steve sits down with Klomp to discuss how h

  5. Hard Founder Truths in 2026 | Listener Q&A

    This week, Halle and Michael sit down for a special in-person listener Q&A to answer a range of founder questions you submitted. Topics include: • What investors are prioritizing right now and how first-time founders can stand out • How to

  6. Can a Simple Blood Test Solve Cancer? | Guardant Health CEO Helmy Eltoukhy

    Breakthrough blood tests that can flag dozens of cancers before symptoms appear are gaining momentum, yet questions remain about accuracy, equity, and how these tools will fit into routine care. In this episode, Steve talks with Helmy Eltou

  7. 📣 Digital Health Download: March 2026

    Pharma ads, biotech IPOs, $1M longevity programs, oh my! This month's Digital Health Download skews towards biotech, which is having a moment. Tune in to hear Halle and Michael cover the latest headlines. We cover: • Why pharma ads are surg

  8. Precision Medicine Is (Almost) Here | Tempus AI CEO Eric Lefkosky

    When Eric Lefkofsky’s wife was diagnosed with breast cancer, it exposed how little technology and data were shaping cancer care, pushing the serial entrepreneur to build a different model. Lefkofsky is the founder and CEO of Tempus, now a $

  9. A Roadmap for Innovators and A Giant Leap for AI | Dr. Bob Wachter & Halle Tecco

    In this episode (recorded live), Halle Tecco speaks with Dr. Robert Wachter, Chair of Medicine at UCSF, about their concurrently released books on healthcare innovation and AI. They share thoughts on the dual challenge of innovation in heal

  10. The New Care Dyad | Dr. Karen DeSalvo

    Physicians now face a world where search bars, chat apps, and large AI models are becoming many people’s first stop for health questions, long before they enter a clinic. Former Google Chief Health Officer and national health IT leader Dr.

  11. 📣 Digital Health Download: February 2026

    We’re back with our monthly rundown of the top headlines in health tech! Today, Halle and Steve sort through the biggest stories shaping the year ahead, from AI prescribing to lawsuits galore. We cover: • AI prescribing (in Utah!) • The FDA

  12. Building the Largest Health Data Ecosystem in the US | Datavant CEO Kyle Armbrester

    It has been said that we don’t have “big data” in healthcare, but instead a large amount of “small data.” In this episode, Halle speaks with Kyle Armbrester, CEO of Datavant and former CEO of Signify Health (acquired for $8B), about why hea

  13. Is Healthcare the Ultimate Test for AI? | Ankit Jain

    This week, Steve sits down with Ankit Jain, co-founder and CEO of Infinitus Systems, to talk about why voice-based AI has become one of the most rapidly adopted tools in healthcare operations, what’s actually working in the field, and where

  14. 🔮 2026 Digital Health Predictions | Annie Lamont

    Is 2026 the year that changes everything in healthcare? Steve and Halle sit down with legendary healthcare VC Annie Lamont for their annual predictions episode to dive into 2026 predictions and trends that founders and operators should pay

  15. The Antidote to the “Industrial Wellness Complex” | Zeke Emanuel

    For our first episode of 2026, Dr. Ezekiel “Zeke” Emanuel, oncologist, bioethicist, architect of the Affordable Care Act, and author of Eat Your Ice Cream joins us to share why he believes the longevity movement is overblown and how real he

  16. Former Presidential Candidate Gets Real About America's Future | Andrew Yang 🧢

    We’re closing out the year with a candid conversation about where America is headed. For our final episode of 2025, Halle and Steve sit down with entrepreneur and former presidential candidate Andrew Yang to talk plainly about the forces re

  17. The Rise of Clinician Innovators | Dr. Reena Pande

    Many clinicians quietly wonder if there's a “next chapter” beyond the hospital walls, and an increasing number are stepping into health tech roles that didn’t exist a decade ago. Dr. Reena Pande has lived that shift firsthand: from cardiolo

  18. Soul-Driven Healthcare Investing | General Catalyst CEO Hemant Taneja

    Hemant Taneja believes you can sneeze and reach a billion dollars in healthcare revenue, but that most of that revenue tells you nothing about whether the system is actually getting better. This week, Halle sits down with the CEO of General

  19. The Haves & Have-Nots Of 2025 | Threshold Ventures Co-founder Emily Melton

    The Haves & Have-Nots Of 2025 | Threshold Ventures Co-founder Emily Melton This week for our 2025 recap, we’re joined by VC Emily Melton, co-founder of Threshold Ventures. Melton highlights her reflection of 2025, which splits the market in

  20. 📣 Digital Health Download: December 2025

    The first trillion-dollar healthcare company, a $298M longevity round, and a telehealth CEO headed for federal sentencing. Last month had range. Today on the show, Halle and Michael sort through the biggest December stories shaping the year

  21. Fixing Rural Healthcare Before It Collapses | Homeward Co-founder & CEO Dr. Jennifer Schneider

    As millions of Americans hit the road to visit family for Thanksgiving, many will pass through, or return to, rural communities. Nearly 60 million Americans live in these areas, yet many struggle to access even basic healthcare as rural hos

  22. How a Small Team Built the Fastest-Growing Clinician App Ever | OpenEvidence Co-founder & CTO Zack Ziegler

    On the heels of raising $210 million at a $6 billion valuation, OpenEvidence is the fastest-growing physician app in history, now reaching over 40% of U.S. physicians and powering 17 million monthly clinical queries. In this conversation, c

  23. Truth, Power, and the Cost of Speaking Up | Theranos Whistleblower Tyler Shultz

    A billion-dollar startup. A promise to change healthcare forever. And behind the scenes… a massive lie. Tyler Shultz (https://www.tyler-shultz.com/) was just starting his career when he joined Theranos, only to discover that the company’s b

  24. 📣 Digital Health Download: November 2025

    Does it feel like we packed in a decade of progress this year in digital health? We think so. Today, Halle and Steve break down the biggest digital health stories of the moment, from funding trends to AI rivalries and new rules shaping the

  25. UpToDate’s AI Glow Up | Wolters Kluwer Health VP BD & Strategy Dr. Holly Urban

    Over 3 million clinicians around the world depend on UpToDate to guide patient care, and now the gold standard in clinical decision support is integrating generative AI. But in a world where AI models often hallucinate, how do you build som

  26. Inside the Rise of AI Agents | Sierra Co-founder Clay Bavor

    Most people spend over 30 hours a year dealing with customer service—on hold, repeating account numbers, and navigating endless phone trees. But what if AI could fix that without losing the human touch? Clay Bavor, co-founder of Sierra (now

  27. Build, Scale, Repeat | Serial Founder Tom X. Lee

    This milestone 200th(!!!) episode of The Heart of Healthcare Podcast features none other than Dr. Tom X. Lee, the serial physician-founder behind Epocrates (acquired for $293M), One Medical (acquired by Amazon for $3.9B), and now Galileo, a

  28. 📣 Digital Health Download: October 2025

    Happy Q4 Heart of Healthcare Listeners! We’re back with your monthly Digital Health Download, where we discuss the biggest industry headlines of the month. We cover: 💊 Pharm tariffs, D2C drug ads, and TrumpRx? 📉 The ACA tax credit standof

  29. Can We Make Cancer Nonlethal? | Reed Jobs & Matt Bettonville of Yosemite

    Cancer drugs cost more than ever, yet survival benefits are often modest—and in some cases, patients can’t even access the care that already exists. After losing his father, Steve Jobs, to pancreatic cancer, Reed Jobs committed himself to m

  30. Lessons From 5,000 Hours of Startup Pitches | EIC of Second Opinion Christina Farr

    Some founders win support because of their product, others because of their story. In healthcare, where trust is everything, the ability to tell a compelling and authentic narrative can make or break a company. On this episode, Halle talks

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