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The Proof Podcast is a space for science-based conversation. Together with his guests, Simon Hill, a qualified physiotherapist and nutritionist, explores the health and longevity benefits that come with mastering physical exercise, nutrition, mindfulness, recovery, sleep, and alignment. Facts, nuance and trustworthy recommendations minus the hyperbole. All the proof you need to live better for longer.
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Treating Obesity Is Treating the Brain | Dr Elizabeth Kazarian
Elizabeth Kazarian is a physician double board-certified in Family Medicine and Obesity Medicine, practising in Washington DC. She treats obesity for a living, which means she spends as much time on insurance appeals as she does on clinical
Most 'Probiotic' Foods Aren't Actually Probiotic | Dr Maria Marco
The word gut health is on almost everything now, from yoghurt lids to supplement labels. So I asked food microbiologist Dr Maria Marco, Professor at UC Davis and President of the International Scientific Association for Probiotics and Prebi
What Bone Density Scans Can't Tell You About Fracture Risk | A Masterclass on Bone Health
In this masterclass, I bring together six experts to untangle bone health, from fracture risk and DEXA scans to strength training, joint pain, and surgery. Dr Lora Giangregorio, Prof Belinda Beck, Dr Deborah Kado, Dr Howard Luks, Dr Lauren
The Keto Study That Wasn't About Keto | Dr Nicola Guess
Practising registered dietitian and senior research fellow at the University of Oxford, Dr Nicola Guess, returns to the show to discuss a new study whose findings were interpreted in quite different ways the week it came out. Dr Samuel Klei
30 Years of Diet Trials: What a Stanford Scientist Is Most (and Least) Sure About | Dr Christopher Gardner
This is Christopher Gardner's eighth appearance on the show. Christopher is a nutrition scientist at Stanford, director of the Stanford Nutrition Studies Research Group, and the author of a new book, Food Sense: What to Eat and Why. He has
My Plaque Protocol, and Why I Started a PCSK9 Inhibitor | Simon Hill, MSc
A few weeks ago I published my own heart scans, and one number travelled further than the rest: a 48% drop in plaque over 16 and a half months. The question underneath that video was the obvious one. How? This episode is the answer, and it
Why Your MRI Doesn't Mean You Need Surgery | Dr Howard Luks
Howard Luks is an orthopaedic surgeon with almost 30 years of experience, and a good deal of his week is spent telling people they do not need an operation. We work through the joints that bring most people into a clinic, knees, shoulders,
Birth, Breastfeeding, and the Truth About Baby Food | Dr Federica Amati
This is part two of my conversation with Dr Federica Amati, Head Nutritionist at ZOE and author of the Sunday Times bestseller Every Body Should Know This. In part one we covered preconception, fertility, and pregnancy nutrition. Here we fo
The Liver Disease 30% of Us Have and Never Feel | Prof Aleksander Krag
Around 30% of the world's population has too much fat in their liver, and almost none of them know it. Liver disease stays silent until it is very advanced, which is exactly why so many people are found too late. In this episode I sit down
The Case for Treating Cholesterol Before Plaque Appears | Dr Thomas Dayspring and Dr Dan Soffer
Almost all of us have atherosclerosis, and almost none of us are told so, because "normal" cholesterol is a population average rather than a physiological target. Dr Thomas Dayspring and Dr Dan Soffer, both Masters of the National Lipid Ass
Bone Health, Falls, Medications & Healthy Longevity | Dr Deborah Kado
Everyone wants to talk about longevity. Almost no one wants to talk about gerontology, the field that has been studying how to age well for a century. Dr Deborah Kado, Stanford professor of medicine and geriatrician, joins me to bridge that
Type 2 Diabetes Remission in the GLP-1 Era | Prof Roy Taylor
Professor Roy Taylor returns, three years after his first appearance, with the five-year DiRECT trial results and a clear-eyed assessment of where diet-driven type 2 diabetes remission stands in the GLP-1 era. The evidence is now solid: typ
Lowering Blood Sugar Without Weight Loss | Dr Nicola Guess
Can you meaningfully improve type 2 diabetes without losing weight? Dr Nicola Guess, registered dietitian and Senior Research Fellow at the University of Oxford, says the evidence is clear: a higher-protein, lower-carbohydrate diet can lowe
The Fertility Test Most Men Are Never Offered | Dr Michael Eisenberg and Dr Natalie Crawford
About one in seven couples are unable to conceive after a year of trying, and roughly half of those cases involve a male contribution. Yet in a quarter to a third of them, the man is never properly evaluated. In this episode I sit down with
Superagers, statins, the latest cholesterol pill and the truth about heart disease risk | Dr Terry Simpson
Dr Terry Simpson is back, and we go deep on the science of protecting your heart and brain for the long run. He is a surgeon and one of the clearest voices online for separating solid evidence from confident hype, and in this conversation w
The Science of Metabolic Flexibility, Zone 2, and Reversing Diabetes | A Masterclass
Metabolic dysfunction rarely announces itself. We tend to think of metabolic health as a line you cross the day you are diagnosed with type 2 diabetes, but the decay usually begins years earlier, at the level of the cell. In this masterclas
New Science of Weight Loss | A Masterclass
GLP-1 medications are transforming obesity treatment, but they're only one piece of the puzzle. In this masterclass, I bring together insights from Dr Terry Simpson, Dr Federica Amati, Dr Mauricio Gonzalez, Dr Christos Mantzoros, and Dr Ste
Fertility, Sperm Health, and Nutrition Before and During Pregnancy | Dr Federica Amati
We tend to treat pregnancy as the starting line for a child's health. In this episode, Dr Federica Amati, Head Nutritionist at ZOE, makes the evidence-based case that the window opens earlier, in the months before conception, and that it sh
Can You Reverse Heart Disease? What My Plaque Scans Showed | Dr Campbell Rogers
In late 2024 a CT scan revealed a small amount of soft plaque in my arteries. Sixteen months later I scanned again, and my plaque volume had dropped by around forty percent. In this episode I ask the cardiologist behind the technology wheth
Reversing Artery Plaque: 8 Supplements Ranked by the Evidence | Simon Hill, MSc
Can a supplement actually reverse the plaque in your arteries, or only slow it down? It is the question I am asked most, and after a 2024 scan revealed early plaque in my own left anterior descending artery, it became a personal one too. Th
How to Lose Weight and Fix Your Metabolism in 2026 | Dr Mauricio Gonzalez
For decades we have treated the number on the scale as the goal of metabolic health. Dr Mauricio Gonzalez, a triple board-certified physician and endocrinology fellow practising in New York, makes the case that we have been measuring the wr
Evidence-Based Exercise in Pregnancy and Postpartum | Dr Margie Davenport
In this episode, exercise physiologist Dr Margie Davenport walks me through what the evidence actually shows about exercise during pregnancy and the postpartum period. Margie chaired the 2019 Canadian Guideline for Physical Activity through
Nutrition for satiety and weight loss | Dr Federica Amati
GLP-1 medications are now part of the mainstream conversation, but the biology of appetite and satiety, the system these drugs operate within, gets far less attention than the drugs themselves. In this episode, I sit down with Dr Federica A
The Surgeon Defending Statins, GLP-1s, and Ancel Keys | Dr Terry Simpson
In this episode, I sit down with bariatric surgeon and science communicator Dr Terry Simpson for a wide-ranging conversation about health misinformation, GLP-1 medications, statins, ApoB, the Mediterranean diet, and the loud contrarians who
Has Optimisation Culture Gone Too Far? | Sarah Ann Macklin
In this episode, I’m joined by Sarah Ann Macklin to explore the hidden psychological costs of modern wellness culture and why pursuing health can sometimes leave us feeling more anxious, overwhelmed, and disconnected. Sarah shares insights
What the Headlines Get Wrong About the Future of Meat | Bruce Friedrich
Six years on from our first conversation, global meat consumption is at a record high, and the harms of industrial animal agriculture have only deepened. Bruce Friedrich, founder of the Good Food Institute, is back on the podcast to argue t
Improving cholesterol and blood pressure with diet | A Masterclass
Cardiovascular disease is the world's leading killer, and yet the prevention conversation has become noisier and more confused than ever. In this Masterclass I bring together the evidence-first material I think is most useful for understand
The Peptides Quietly Accelerating Aging | Dr Valter Longo
The peptide and GLP-1 conversation has reached a fever pitch. Growth-hormone-releasing peptides are being marketed as longevity tools, GLP-1s are being treated as a default rather than a last resort, and a wellness aesthetic of higher IGF-1
The Diet That Lowers Cholesterol Like a Statin | Dr Andrea Glenn
Plant-based nutrition has rarely been more contested. Seed oils are vilified, butter is celebrated, protein is treated as a pure quantity question, and nutrition epidemiology is routinely dismissed by people who have never read one of its p
Food Labels, Fibre, and Ultra-Processed Foods: What Really Matters | Rhiannon Lambert
Ultra-processed foods are now the central nutrition conversation of the decade, but the gap between the marketing and the evidence has never been wider. In this episode, I sit down with registered nutritionist and Sunday Times bestselling a