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The Peptide Lie: What a Drug Developer Reveals About the Compounds Everyone Is Injecting | Dr Leigh Baxt
Peptides are being marketed as solutions for everything from injury recovery to longevity, but what does the science actually say? In this episode, Dr Leigh Baxt joins me to break down what peptides are, how drug development really works, a
Preventing and reversing osteoporosis | Dr Belinda Beck
In this episode, I’m joined by Dr Belinda Beck to challenge long-held beliefs about osteoporosis and bone health. We break down what actually works, what doesn’t, and why many people are being given outdated advice. We explore the science o
New microbiome science | Dr Tim Spector
In this episode, I return to a conversation I promised to continue - sitting back down with Prof Tim Spector, MD, to explore everything that has changed in microbiome science since Episode 224. Tim and the ZOE team have now published a land
Food and weight loss | Dr Kevin Hall
In this episode, I’m joined by Dr Kevin Hall from the NIH to unpack the science behind ultra-processed foods, energy balance, and the new U.S. Dietary Guidelines. We explore what controlled feeding studies reveal about why people tend to ea
The exercise that builds strong bones and better balance | Dr Lora Giangregorio
In this episode, I speak with Dr Lora Giangregorio about how to train for stronger bones, better balance, and long-term independence. We break down what actually matters when it comes to preventing fractures and improving bone health. We ex
The dietary guidelines great debate | Dr Christoper Gardner and Dr Ty Beal
In this episode, I’m joined by Christopher Gardner and Ty Beal to break down the science and debate behind the latest U.S. Dietary Guidelines. We explore ultra-processed foods, protein recommendations, plant-based alternatives, and how nutr
The sleep habit that quietly raises your risk of heart disease | Dr Kristen Knutson
In this episode, I’m joined by Dr Kristen Knutson to unpack circadian health and how timing influences our metabolism, cardiovascular health, and sleep quality. We discuss the role of morning light, meal timing, exercise, and regularity, an
The Science of Exercise for Women 40+: What to Prioritise (And What to Ignore) | Dr Lauren Colenso-Semple and Dr Alyssa Olenick
Dr Lauren Colenso-Semple and Dr Alyssa Olenick join me to answer a question I hear constantly from women in midlife: “Why am I putting in so much effort, but not seeing the results?” We break down what matters most for strength, body compos
Building muscle for longevity | Dr Brad Schoenfeld and Alan Aragon
Dr Brad Schoenfeld and Alan Aragon join me to explore protein requirements, recomposition, and how to structure resistance training for long-term strength and muscle retention. We discuss calorie deficits, effort, failure, recovery, and the
The good and the bad of the new US dietary guidelines | Dr David Katz
The 2025 US Dietary Guidelines are out, and they’ve sparked debate across the nutrition world. In this episode, I sit down with Dr David Katz to examine where the new recommendations align with science and where they diverge from the Dietar
Reversing atherosclerosis with diet | Simon Hill, Msc
Can diet really reverse atherosclerosis, or is that an overpromise? Since sharing my own coronary CT angiogram results, this question has come up almost daily. In this episode, I revisit the best clinical trials to see what the evidence act
How body fat affects your metabolic health and risk of metabolic disease | Dr Robert Eckel
I’m joined by Dr Robert Eckel to unpack why obesity is far more complex than a BMI number and why insulin resistance plays such a central role in cardiometabolic disease. We discuss preclinical versus clinical obesity, fat distribution, met
The science of fertility: Hormones, inflammation, and what you can control | Dr Natalie Crawford
Fertility is not just about timing ovulation. In this episode, Dr Natalie Crawford explains how sleep, stress, insulin resistance, diet, toxins, supplements, and lifestyle choices influence egg and sperm quality, miscarriage risk, and ferti
Why some people gain weight eating the same food | Dr Karen Corbin
Could your gut microbiome influence how many calories you absorb from the same food? Karen Corbin explains the science behind energy absorption, faecal calorie loss, and why feeding your microbes may support metabolic health. We also cover
Protein, increasing bone mineral density, saturated fat and more reflections | Drew Harrisberg
In this episode, Drew Harrisberg and I go deep on life beyond macros and metrics. We talk about gratitude, regret, ageing, and how constant optimisation can quietly pull us away from what actually matters. We also cover living with type 1 d
Protein amount, quality and timing | Dr Luc van Loon
I sit down with Dr Luc van Loon to unpack what really happens to protein in the body, from digestion to muscle and organ tissue. We explore why muscle protein synthesis is often misunderstood, how inactivity drives muscle loss, and what the
Evidence-Based Strategies for Heart Health and Longevity | Highlights of 2025 (Part 2)
In Part 2 of Highlights of 2025, I revisit some of the most important conversations from the year on The Proof, covering cardiovascular prevention, blood pressure, cholesterol, nutrition, sustainability, and performance. Featuring insights
What the Science Really Says About Nutrition | Highlights of 2025 (Part 1)
Welcome to Part 1 of our Highlights of 2025 series, where I revisit the most important conversations from the year on The Proof, spanning nutrition science, misinformation, and long-term health. This episode features highlights from Dr Matt
Science-based nutrition to prevent a heart attack | Michelle Routhenstein, MS, RD
In this episode, I’m joined by cardiac dietitian Michelle Routhenstein to unpack why heart disease prevention is still so misunderstood. We explore cholesterol confusion, blood pressure, saturated fat, carbs, supplements, and why personalis
How to build a healthy gut using the latest microbiome science | Dr Suzanne Devkota
In this episode I sit down again with microbiome researcher Dr Suzanne Devkota to explore what a healthy microbiome really is and how we can support it. We unpack diversity, early life programming, fibre and microbiota accessible carbohydra
Why chasing happiness makes you miserable (and how to choose better values) | Mark Manson
In this episode I am joined by Mark Manson, author of The Subtle Art of Not Giving a Fck*, to talk about why so many of us build our lives around “shitty values” and what it takes to change. We discuss regret, shame and the stories we tell
Food Truths from the world's top nutrition scientist | Walter Willett, PhD
Dr Walter Willett has spent more than fifty years at the forefront of nutrition research, leading landmark studies that have shaped how we think about fat, carbohydrates, protein and chronic disease. In this episode, he joins me to untangle
RFK Jr, MAHA, and the fight for America’s diet - What’s really going on | Dr Jessica Knurick
Dr Jessica Knurick joins me to examine the systems influencing America’s health. We discuss the gap between individual choices and public health realities, the rise of MAHA, and why many proposed solutions fail to address the real drivers o
Science-based exercise tips for women | Dr Lauren Colenso-Semple
Do women really need a completely different training plan to men, or has the "women are not small men" message been taken too far? I am joined by exercise scientist Dr Lauren Colenso-Semple to explore what the science actually shows about f
The 5 most important protein questions answered with the latest science | Dr Matthew Nagra
Protein is one of the most talked-about nutrients, yet confusion remains about how much we need and which sources are best. I am joined by Dr Matthew Nagra to unpack the science on protein intake, plant versus animal sources, and how to bui
Maybe this is happening for you: On finding meaning in suffering | Axel Schura
I’m joined by author and coach Axel Schura to explore how hardship can lead to transformation. Axel shares his story of stage four cancer and the mindset shifts that inspired his new book “Maybe This Is Happening For You, Not To You”. We di
The doctor who beat cancer and now helps others do the same | Dr Dawn Mussallem
Dr Dawn Mussallem’s life has defied all odds. After surviving stage 4 cancer, severe heart failure, and a heart transplant, she ran a marathon just one year later. In this conversation, I sit down with Dawn as she shares what she’s learned
5 ways to lower your blood pressure | Raymond Townsend, MD, PhD
In this episode, I continue my conversation with Dr Raymond Townsend, Professor of Medicine at the University of Pennsylvania. We explore how to optimise and treat high blood pressure through lifestyle, medication and a deeper understanding
Steps to optimise blood pressure and kidney function | Raymond Townsend, Md, PhD
In this episode, I am joined by Dr Raymond Townsend, Director of the Hypertension Programme at the University of Pennsylvania. We discuss what drives high blood pressure, how it affects the body, and practical steps to protect your heart, k
Lactate: The Key to Metabolic Health, Mitochondria, and Longevity | Dr Iñigo San Millán
In this episode I am joined by Dr Iñigo San Millán, exercise physiologist, researcher, and coach to Tour de France champion Tadej Pogačar. His work places lactate at the centre of human health, showing it as a fuel and biomarker rather than
