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This Week in AI

von Jason Calacanis

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An experts-only AI podcast: Think the 'All In' podcast for AI. Jason + 3 CEO-level experts breaking down the news & trends.

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  1. Would you pay $1000/month for your agents? | TWiAI E38

    Thanks to our partner, @Paypal! Pay zero processing fees on your first $100K in eligible PayPal payment volume. Learn more athttp://paypal.launch.co/* Today’s show: Grok Bot users maxed out their weekly limits over Halloween Weekend, and Sp

  2. Anthropic’s Money Machine, “Slop” Degrees & the Meat Proxy | TWiAI Ep 37

    This Week In Startups is made possible by: PayPal: https://paypal.launch.co Today’s show: Anthropic’s S-1 is finally out and it’s a beast: $16.3 billion in revenue in the first half of this year, up from $1.2 billion in 2025. Plus a $1.6 bi

  3. No One Likes Any of Sam Altman’s 3 AI Endgames | TWiAI E36

    This Week In AI is made possible by PayPal:http://paypal.launch.co Today’s show: Sam Altman told OpenAI staff that there are only three ways for AI regulation to go: an international watchdog, every lab merging into one CERN-style entity, o

  4. Why Fortune 500 Companies Are Quietly Switching to Open Models

    This Week In AI is made possible by: PayPal: http://paypal.launch.co Today’s show: Companies are spending $1 million on AI in a single month, but can’t always point directly to any resulting revenue. Jeffrey Morgan of Ollama joins Jason to

  5. Data Centers Aren't Killing the Grid. They Could SAVE It.

    Thanks to our partner, @Paypal! Pay zero processing fees on your first $100K in eligible PayPal payment volume. Learn more at https://paypal.launch.co/Today’s show:Demand for AI requires America to build data centers faster than the power g

  6. Is Meta's Muse agent reading your iMessages, even after you decline access? | E33

    This Week In Startups is made possible by:PayPal: https://paypal.com/businessToday’s show:OpenAI is delaying GPT-6.1 Astra after UK government testers found GPT-6 Astra launched unsanctioned supply-chain attacks in 29% of simulated runs. Ja

  7. Why OpenAI Should Buy Off the World’s Top Mathematicians | E32

    This Week In Startups is made possible by: PayPal - Pay zero processing fees on your first $100K in eligible PayPal payment volume. Learn more athttps://paypal.launch.co/ Today’s show: OpenAI is claiming to have solved more than 100 math pr

  8. The biggest AI threat still comes from humans | E31

    This Week In Startups is made possible by: PayPal:http://paypal.launch.co Today’s show: Dario Amodei and Sam Altman are apparently scared of AI models going rogue. Swarms of agents spontaneously deciding to copy themselves over to thousands

  9. OpenAI's chief scientist wants to slow down | E30

    This Week In Startups is made possible by: PayPal - Pay zero processing fees on your first $100K in eligible PayPal payment volume. Learn more athttp://paypal.launch.co Today’s show: OpenAI's chief scientist wrote a lengthy manifesto arguin

  10. The real danger is the gap BETWEEN two robots | E29

    This Week In Startups is made possible by: Paypal Today’s show: Anthropic gave AI agents hands, allowing them to control real-world equipment like robots and microscopes… but is it safe to give autonomous agents their own lasers? Gatik’s Ga

  11. XBOW Founder: “Your Infrastructure is Not Safe” | EP 28

    This Week In Startups is made possible by:PaypalToday’s show:XBOW’s AI has held the top rank on the HackerOne leaderboard for more than a year. On TWiAI, founder Oege de Moor (who also built GitHub Copilot) tells us that no one’s infrastruc

  12. Anthropic is training to destroy your company | EP 27

    This Week In AI is made possible by: PayPal - Pay zero processing fees on your first $100K in eligible PayPal payment volume. Learn more athttp://paypal.launch.co Today’s show: *On “All In,” Gavin Baker said that Anthropic leadership privat

  13. Why Anthropic is watermarking every word Claude writes | E26

    This Week In AI is made possible by: Paypal Open Today’s show: Anthropic’s new Claude watermark travels around any and all copy-and-pasted text. Is this a logical response to AI slop, or more overreach from those regulation-loving Europeans

  14. Is open source AI really ahead of the frontier? 3 builders weigh in. | E25

    This Week In Startups is made possible by: PAYPAL OPEN Today’s show: China’s Alibaba just dropped a 2.4 trillion parameter open weight model that the company claims only trails Anthropic’s flagship among the major frontier rivals. Of course

  15. Are we already in the Singularity? | E24

    This Week In Startups is made possible by: Paypal Open Today’s show: On a podcast this week, Sam Altman made a bold declaration: “We are now, like, in the singularity.” A bold claim which Alex puts bluntly to this week’s panel. Grant Lee of

  16. America already lost one AI race | TWiAI Ep 23

    This Week In Startups is made possible by: PAYPAL OPEN Today’s show: This week, our panel of AI experts — Anand Kannappan (Patronus AI), Ori Goshen (AI21 Labs), and Alex Finn (Henry Intelligent Machines) — join special guest host Lon Harris

  17. Grok 4.5 and GLM-5.2 kick off Token Price Wars | E22

    This Week In Startups is made possible by: PAYPAL OPEN Today’s show: The price of tokens keeps tumbling down, and it’s changing who controls AI. Grok 4.5 and GLM-5.2 landed within two weeks of one another, offering powerful alternatives at

  18. What happens if China pulls the plug on open-source AI? | Ep 21

    This Week In Startups is made possible by: PAYPAL Today’s show: China is weighing a ban on foreign access to its top AI models… the same low-cost open-weight systems on which half of the Valley’s startups are building. So we asked our two a

  19. Mythos, Sonnet 5, GLM-5.2 Dominate the News Cycle | Episode 20

    This Week In Startups is made possible by: PAYPAL Today’s show: The US government won’t let you use the most powerful releases from US AI labs… but a Chinese lab is giving away their latest frontier model for free. This week, we’ve got thre

  20. Are world models the unlock for Physical AI? | Episode 19

    This Week In Startups is made possible by: Paypal Today’s show: *When we think of “Physical AI,” most of us conjure images of humanoid robots and self-driving cars. But there’s a lot more to the category than just breakdancing Chinese bots

  21. Why AI Models Aren’t the Product Any More | TWiAI Ep 18

    SpaceX bought Cursor for $60 billion. Satya Nadella says companies need to stop relying on third party AI models and build their own “token capital.” The focus is shifting from LLMs to the application layer sitting on top of them. Here to u

  22. Hermes Agent, NotebookLM & LiveKit Founders on the AI Agent Race | TWiAI 17

    Apple just paid a rival a billion dollars a year because it could not build Siri itself, and that tells you where the AI platform war actually stands: the edge has moved up the stack, from the model to the agent layer sitting on top of it.

  23. AI Layoffs, Compute Costs & Agents | Naveen Rao & Alex Finn on This Week in AI Episode 16

    The future of AI isn't about whether the model is smart enough. It's about whether we can afford to run it. We dug into the AI cost panic, the energy wall that's coming for compute, and why "developers are disappearing" gets the economics e

  24. "Nobody Lost Their Job to AI, Just the Promise of AI" - This Week in AI Ep 15

    The AI jobs panic is here. Meta cut 8,000. Intuit cut 3,000. CapEx went up. Nobody can agree if anyone has actually lost a job to AI, or just to the promise of it. We dug into the GPU squeeze, the new craft of "reward engineering," Pope Leo

  25. Grads boo AI, Reese Witherspoon gets dunked + Karpathy joins Anthropic | TWiAI E14

    The frontier labs are coming for the application layer, and they're going to steal your idea. We dug into Andrej Karpathy's move to Anthropic, the new rules of AI etiquette, and why graduates are booing AI at commencement speeches. This wee

  26. How the 1% Will Own Compute (and What It Means for You)

    The future of AI isn't a smarter chatbot. It's a model that watches your screen, listens to the room, and acts on what it sees. We dug into Thinking Machines' new interaction model, what it means for compute, and the layoff wave that's alre

  27. Is Anthropic a Cult? AI Beats ER Doctors & Recursive Self-Improvement | This Week in AI E12

    This week, JCal sits down with two builders working on opposite ends of the AI stack: Naveen Rao, co-founder and CEO of Unconventional AI (his $4.5B startup rethinking the computer from first principles), and Trey Holterman, co-founder and

  28. Cursor's $60B Deal, DeepSeek V4 & the Death of the AI Moat | This Week in AI E11

    This week Jason sits down with three founders at the frontier of AI infrastructure, software development, and vertical AI: Matan Grinberg, co-founder and CEO of Factory; Russ d'Sa, co-founder and CEO of LiveKit; and George Sivulka, founder

  29. Aravind Srinivas & Edwin Chen: The $1B Bootstrap, Apple's AI Edge, and Benchmarks | TWiAI E10

    This week we sat down with Aravind Srinivas and Edwin Chen. Aravind is the co-founder and CEO of Perplexity, whose revenue has grown from $100M to $500M on the back of Perplexity Computer. Edwin is the co-founder and CEO of Surge AI, the da

  30. The Future of AI: Personal Agents, Taste & Private Data | Lin Qiao & Demi Guo | E9

    This week we sit down with Lin Qiao and Demi Guo on This Week in AI Episode 9. Lin is the co-founder and CEO of Fireworks AI, a frontier inference platform processing tens of trillions of tokens per day, built by seven ex-Meta engineers who

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