Healthy aging – Was gibt es Neues vom Chef des Buck Instituts Eric Verdin?

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0:57 Werbung. In the willcome to stay young, i have an spoken to him in three month. The last time was at the Global Health Band Summit and February in Riad and so much as happensins them, so it's high time for an update from one of the wills most renound aging researches the president of the bug Institut for Research on Aging, Professor Eric Word in I'm happy to welcome you to stay Young Eric. But good morning or good afternoon and i good to see you're get.

1:30 Good morning, unusual, but perhaps this will be in assassary more off in the future requestion about the activities of the Trump Administration, the new guidelines of the powerful and financialy strong ni h. With mean enormes cuts for many research institutions have been suspended by the chords for the time being, but what does this mean already for bug today?

1:57 For the bug today, i think really so this are unusual time for for sure one of the key is you that we are confronted with now is the assertanty because they were directives from the Trump administration interps of. The am out of grands that would be this tributeed, but this is all being fording court, and so we do that no and i think it's going to take of you mons that being set i think everyone wrecking nice is that DNIH budgets i're going to be got the question is by all match is a ten Prozent twenty Prozent the Trump Administration is is aiming for forty prozent given defekt that on was haf of our budget. Is coming from the NH for the back or for anya the organisation that's conducting

2:49 by medical researching in the US outing. This is going to me in the significant cuts and and i should see a significant up a genity for europe because they are a lot of the european scient is to or we will, we're estublition the US we're like be thinking me be the next stop in there core rears good be the US. I can be the europe and in a wade it's i grup in in belgum and was attracted to the funding sichuation in the US we'm i see not the opposit brain drain hapening you know hoppoly it will saddl one think that is also go to remember that i try to to do is a fact that the ni h is been an incredible engine of. Economic access for the US and you know the date asses that about every dollar.

3:36 This bin invested in to the nih and them's a basic research as you'll think about two dollars of economic outputs and that's bring you're markable if you think about and you go them programm, so we have that cooler hits will privail and that the Administration will seeed of on you a what we doing and the public sir and we seas it the sucess of medice in all that.

3:57 New advances is is a result of the the work of the anage so i try to remain optimistic and while o so preparing for whatmy.com in the future. For example, that's have a look of at the MRNA research and particular inkluding new vaxens is no in the word of collap stay say what do you think about this? Yes, this is we're going the emotions and politics and and frankly, think that's just have nothing to do it science a get mixed and a very dangers mixture and combustive mixture for some reason the mr anive xenes, which we're really the discovery that god as out of the previous pandemic and rich all of us, wrecking nice or incredible important tools. For the rapidity that they're allow is to to developed new vaxines, this became a political

4:57 as you. There's a hall french grip of be polo clame that they're dangers i remain convence that they are incredible in this, this is one we're seen and they also off her potatial be on vireses for cancer. A treatment so I'll for gened therapy for the condition. We'll see i think right know it is difficult for example to get grands if you're can menschen no the term mrnavaxi, but oh for me with the future, i think scientes will beable to make the case better then these are save and and axedy hilly effective one think that i think is important for all of us for me as a scientes have in word, my hol life as a scientes.

5:41 And big down a position of leadership is the fact that and unministration is it will to comin and in some way a sail science is a reflexion of the fact at as sign this, we've not dun and not of a good job and not a percerasive job and not to convince of public of the value of what we doing and i was imagine that um. That it's anybody with tried to touch the na h the public with rice and what's that the aministration know not this is not be touched.

6:10 Nothing is happening and i think it's a reflection of the filled or fillio to community the imports of what we doing and this is why i think podcast like hears or science communicators play and enormes Roll and really highlighting the value you don't not was are. In this business, i just what's they mustov us are in this business not to like monty not to be film is, but for the passion of really make a difference in the world and i think it's clear that we all benefiting from. Long lives and and healthing and many cases i remind people that we live twice as long is we used to a hundred fifty years a go, that's incredible on average and i think there's still summage potential to continu in crising

6:58 are have and benefiting from all of this signs and i think hop for me, this is only a temporary set back and and we will can back and continu to do what we know hot to do. So that's move on to the positive news. Back and you're partner company phenom have have reseved ran. I'm right two Millionen dollars in funding for your pof project with this you one to revolutionize have care with the help of ai what is pof? So buns for first and i see a few words about phenom hef what is not a company, but it was so not for profit in the ben and word.

7:37 Oh so Organisation. That is big that was fund it by lee hot and with home we have intered a long term, a strategic partnerships or Lee hot bekam a professor at the buck and and we like to you will we're clusly with many of is phenom health collies, phenom the hole ideo phenom health is that car it you go to see you're doctor today you're most doctors rely on a very small number of. What We Call Biological Tests if you go and get you're blood John, You're Doctor will measure typicly maybe fifty different markers you're blood, we're go will you're himoglobin you're you're rea and this is a typ of test at you do on so your we're doctor trice to see ok i you in good health for not most doctus is i mention rely on fifty to a

8:32 hundred different. A markus today with the technology that we have and this technologies are what we go the omix proto omix metabol omix transcrip omix we can reliable measure out of the blood, a hundreds of thasens of different variables. Ok, so that's there's an incredible discripancey between what we have in the climic and what we can do. In an experimental setting thundation of or wora potphinom health is this idea that they has to be a lotmore information based on this hundreds of thesens of variables that we do not access that we do not understand and so the home and of the the collaboration we can phinom health and the back institut is to see ok, that's start measuring this variables and in one blood raw we can

9:25 generate. Relatively easy, a hundred thousand, different variables and that's start looking at all of them and tried of the terman. We're some of there was axually more predictive of health and and disies and so. This is also part of a hall revisiting of the hall field of aging right now medicine is preocupideed self mostly with treeding you what you get sick. A vision is that we want to privent disies and the wait a privent disies is to identified i'm very really and we have some evidance using the tools that i just describe final have that we measural of this variables, we can the text the acurance or a predictive markers for a disies fifteen to twent years or that one the disies is going to have

10:13 and for example. That is in right now that you have hard attack you go to see the doctor. The Doctor will trit you and we can save must bepoled from hard attacks, but we have evidance that the signs of the hard attack we're already have in in three and the world in what you would go see you doctor and the doctor with beable to do regret of bluddraw if we are very complex bluddra.

10:38 And we would be apple to predict if you don't change and you think to you're lifest out to they for from now, you will get a heart attack so that what be a very the inform of medicine that what opoly allowers to privent a holseries of this is and what i'm talking about heart attack. This is only one alsimers is another big one most of the therapies and alsimers fail becausewe.com to late. And so, and here going we can have markers that we can i that the five fifteen to twentineers arely that or predictive or what's going to have and and this we know man of this this is or driven by lifestyle the ideers that by haveing and the pling this diagnostic tools we will beable to have trurly präventive medicine and.

11:22 The prosper not the prosper, the a collaboration that was funded by arpa h, which is a another organisation from the government here in the US. The paths that he that you menschen is our forest at themed to really start laying out the granwork for this very complex data analysis, now the lasting that i one it last point i want it to make.

11:46 Is the roll of ai and this obviously in a doctor or you and i can deal with a hundred variables. We can look at them. We can see them change what you dealing with a hundred thesand values, there's no human brain that can understand this and and so the hol roll of ai in this is to to analyst this very large that is that and chid to understand them better and it is a nintigreal part of to holafred. So Tell me when will this part?

12:16 Project be a product rady for the market for me. Or her to say because there are a number of issues relative to this one this we know two and to stand the systems better and so i with to dick the hole studies about five years. This is ok, it's we are dick and this five years to study it second, there is a cost to this technologies and ryan all there they are to expensive to be the floid in the klinik.

12:45 The the hope and the thinking is leehood was the coalidor of this projekt with us invented the first DNA sequenting machine machine, and this is back in when he started is lab and and the sevenees and this dna sequenting machine let to the sequenting of the human geno, which the first lee remines as all the time, the first human geno cost 3 billion dollar.

13:11 And today four to years later, you can get it done for hundred Fifty dollars so you can in my you considian enormes contraction of of cost and so the prediction by lean and asses that if this technologies or starting to be deployed with and ten fifteen mabbey twenty years they will be com so shape that the will big part of your rutine exams or at the.

13:35 Dr. I'm to old. We will we will, but we will still be it around in ten fifteen twenty years and we will batif it from this technology. Ok, i've can researching kiton bodies for a some time. I found your announcement now that kiton bodies can modify missfuled beta emeloid proteins alowing them to be removed by cellulo cleansing.

14:03 Extremly interesting i get i should we take and key to diat or should we take keytone easters as a diatary supplement to prevent alzheimer's please. That's not very good question, so I'll we have publish the navidance that one we but my so on a key to john it. They do a peer to age better the live longer and ramarkabley one of the the tissues of the organs that we solbeing the most protective aging was the brain and ramarkabley mys on this kitage anic dyt showed i can the improus memory as they h versus stand the mouse and on kitage anic dyt we'll like to the slow lead loose memory, so this in carage us to reidy try to under sand.

14:55 What is the effekt of kiton bodies and major kiton bodies is call bhb, but i hadroxibuterate and we and ded phone that it is able to just by it self to helpin and in not refolding of some of this upnormal proteins that form aggrigits joing altsimers this is so this is a and in vitro study a lab study, but. Independity of this with benable to show that kito genic diat is really nora protective we've also given it to mais that or prom to a disease that lux like out simers disease. For example, if you we can engine your mais, what's some unic proteins that or associate with us simers disease in humans and this mais show acetarate the mansure and what you but them on a kito genic diat again.

15:47 They are protective and there's and a dotal evidance in the literatur that's being and a kita genic dight my actually improve cagnition in humans is well, but officy there we don't have long to am klinical chiles now the problem with a kita genic dight and i can speak about this to because i have been on a kita genic dight i'm not on one now but i have trid it for i up of your is a diffical task because a sensually you. They're two ways to be a three ways to be in kitosis on one is long term fasting of this, the you can do fasting your pisotity, but you can not fast at re day all the time you have to e the second way is to exercise, there's a forms of long term exercise that will in

16:33 doers kitosis, but you can out do this, you can not i can not run treeours a they. And the other way is to restric carbor hydray to decrease you amon of sugger all forms of carbor hydrays that you eats and that's the way most people go on a kit to johnny did this dides or complicate it to be onest because that means no bread, no potato, no pitza, no pastry, not of the things that make live some time special and so.

17:01 The very restrictive you can't get almost can not eat in the fruits as well can's fruits contain shugger. There are a number of people of a go on the is kitor genic dides and there's studed for long time, there's a clear evidance that they're protective again tiped to die a bd is so there's a lot of good things about this dides, but they are for most part diffical to follow so we can up with the differne idea with is the ide of this what you mention this kito on esters.

17:31 So a kiton astors are artificial monicules that are made out of the major kiton buddy and another parts. And when you in just do's your buddy endters a state that is very simut of to kitos is and what you can measure, but i have axibutorate in the blod and we in intrediment or reeffidance in animal models, we have actiony seen.

17:55 Manu of the beneficial effects of a kito genic diat we capitulated by this monicules and we're schon this and noaly in mais, but also we conducting clinical childs in humans and we have a product on the market that action you is a kito anestor so i what so it's still are the days, but the prediction is is that this can be com in alternative reway to keep your memory gering the aging Prozess. Here of a chapter about keytone hastes as an interview with you in my you book, so you menschens mais sure mais are good model organisms, but i saw a post from you you set yes, mais a good model organism on rich we can test long genity research and therapies now you say also mais are mais and live short lifes humans.

18:52 By comparison are the naked Mode rats a mong the Primats and we live exceptionaly long lives for a wasize and we a not really comparible do we know need to shift research and development away from the mouse model? Yes, I'm glad you so my Post. I was a tring to be a little provokative because there's a hold the bate ray know that's happening in terms of you know hows and we conduct. Reserch and there's some me make clear of the point at i think mies are on important modal, so are frutflies so are c eligance a little warm that we study so we want to study biology. I think it's good to study it in of a ridio system, there's one modal system, which is study it last and all of the other ones and it's humans.

19:48 And i think the point of the post that you saw was to make the case that mabi we should stop the humans mo and the risent for doing. This is one. We study aging, for example, in mais we learning a lot of important things, i'm surling we'll never tried to dominage the merit of the studies, a work and mais and all the at in will models as ben instrumental to everything we know about aging research to they but we also are supported by a public.

20:16 Who gibs us money so the una h or the Max-Planck-Institut or the humboldt and all of this organisations that are supporting research Agent typicy funded by the public and i think the public is the manding of us more solutions to the problems of aging. And i think there needs to be more offered to really a revisit human as a modal system, and the reason i suggestive this is that are somit he things that we can now do in humans or in sells from humans that will a lots to excelerate the hole prosess to generate new jugs and new interventions against the aging prosess or the reason for the post was really to just for it out there that i think we should consider to humans as a good. Equivalent modal system typic

21:03 lead this is not to have research Word Research start in the simplus modal system and that in the works it's away up progressivly to one war complicate it. The problem is that you my find and intervention that words quite will in mais, but you have a drug and you think of my go this is going to be something invasing and that you was to humans and it fails and actually the etrition rate as we go from mais to human is enormus what is a lot of things that get last?

21:31 That do not work and fill and my argument was that maybe if we start it more aftin for men the regly we will be more sucess for that, they will uping drikes that was the hole point of this coles. The not a Post Eric Rerden Post iphone it's increisingly exiting few wicks a go i Gass you set that GLP One reset to agonists wait loss injections.

21:58 Can be come the moest interesting longivity drugs of the near future. Tell me more. Yes I've standby this. I think this is a and exiding really new development. There is one thing that that's truck me as we've been studing aging now at the molicular level for five thirty years is there's one pathway and mecking is that keats poping up. And this is all link to are ability to metabolize glucoes chugger and the roll of insulin in the spotway so as one we e chuggers, we need insulin to to metabolize it and, and if you don't have insulin you get in to type one div Bd s if you big am insulin resistance you have type to div bd s it turns out that one scientist study and try to identify what i'm malecut a mecanism.

22:53 Of aging, one of the pathways that emergis all the time is insulin signaling how insulin works and so this has been identifieed and a little warms the eligance and fruit flys and multipolorganism and acruding and humans. There's also not a thing call the itp intervention testing Programm, this is an IH supporting Programm that will Test. You think drugs that you can nominates for example, if you think you have a drug that will delay aging, you can right of my shortpaper to a two pages and it to the aniage making the case for the fact that drug might be incrising lie, spam, and it will be reviewed by comedy of expert, and if they are convince. Of you're hypothesis, they will like you do the experiment and they will a feed the drug to

23:48 mais for two years and measure the life spin and so this programm is been in place for. I think what in ten years, there's tested seveny different molicules and i think what in ten if in merages have in a very strong effekt on life spin so bezo drugs when given to this animals what in krise that life spin by minim minimum of tentimes to twenty Prozent.

24:10 So really significant if you think about a human that what be a jug that we're increase all life span by fifteen to twenty years so three of or markable in exiding and what's amazing is that many of the jugs that have a merged out of this program. A targining again gluco is an incitent signaling and seval of these jugs archued in the klinik, one of them is famers goal a carbos at prvence the absorption of shogain your intestin. I not a one this kind of glyphosin, which is or guardians.

24:41 It's a type two di bd s medicine with prävents you know lowers your blood shogger and by working on the kidney and there's been a lot of talks about the roll of met for men, which is another type two di bd s drug with also them's to be increasing live spand or hellspand or both so meaning to see there are so many things. So many convergion navidance that always point to that pathway in signaling and glukros metabolism as being the pathways, the Drive Aging One the Inquitance GLP One Aggrenist Simagritite as sampic One Jaro z Bones all of these names that we all here about kim on the market, these or drugs that we're anitialy develop this anti diabetic drugs again targeting insulin signaling.

25:31 Secondary Discovery was defekt at this drugs also increase a lot people to loose wate and so, and now we have millions of people in this contry across the world with bintaking these drugs for plus to ten years, so there a peer to be remarkabley save, but the think that is a merch as is quiet interesting is this them to have some protective effekt on the brain on the kindy on the hard, so we sing. Agan the same patron in merge a drug that was anitialy developed aganstive to die b d's themes to have global a have protective effekt and so the prediction and there's a hole school of people we have been experimenting on this taking them at lorados, so these a people who my not be a beast that my not be diabetic, but there's still taking the

26:21 drug and in some case is supporting some interesting beneficial effekt so. So, i was going a little bit of a provokative Post not provokative for the sick of being provokative, but really bringing it up to people's consusness that we're can really but be think about this drucks as they be a first global enta aging druck that will be avalable so we will see i just see the experiments have to be done and no long term, but there's some very promising.

26:51 Ja, and so many people a taking now this wate los injections. For a long javity effekt, and they don't know wither it's really proved bet, they do it love question the twelve howmarks of aging a something like the holy grail at the entrance to long javity science for a few weeks now there have been 14 howmarks and we a looking more and more closly to see with a certain howmarks could be fundamental ones that's all to speak controll the others.

27:25 Please and like in us. The holmers of vaging was a scientific paper that was rittin by friend and a callic guido kromer who was believe is austrian and french and spandishy as multiple nationality's brillian man kim up with the ideas and that the idea of categorizing the problems that are sociate with aging.

27:51 In the Series of hollmarks this hat been done befor for cancer. We're so a very classic paper call the hollmarks of cancer with identifieter hollseries of malecutor abnomalities in cancer. This case it did it for aging and what it was is a soed of in the temp to organized the field and trient to describ all of the abnomalities that happen in cancer, not the reason white. This Initiative afric was in porn the pickers. It's really a love you to defined what the problem is the problem of aging is is very complex as you menschen with a been between tenen forteen the for in home markets of aging and people is still arguing as to home in the execly that are it's a futal discussion the problem

28:38 is that aging is multifectorial. And with also me that they is not going to be a simpel and Sir to aging or magic pill at some people still home. I will so everything so we we want to understand aging and fid it we have to understand all of this variables, the paper of the holmarks of aging was support as an Organisation Tool, but we are all realising that all of this holmarks or insticutly link to we chader.

29:09 It's not they're not and re disreate little boxes and with something happens at you have to sold if you interfear of example, with one of the holmarks you like actually be korrekting tree at a holmarks and this is we're the feel this right now is string to get i'm not to more integrateed view of the this holmarks of aging and the mecked is movaging a why is that import is a dispoint we all wrecking nice that for example, you can so. The my to conria problem and my to conria r d's little think up them is the power center in the cell that all are you to generate energy and we know that as you h my to conria bekommen less and less effective so my to conral this function is one of the hallmarks of aging, but we

29:58 also know that if you so that problem you don't so auf aging and we know that my to conral function. We'll have an effect on stampsells for example, so stampsell this funkion is also a home mark of aging so right know what the feel is really trine to do is to get a much or integrate you of the aging process and also trine to identify what we goal note that is hominy interventions do we need to generate against aging and how do this intervention interact with the chader that's really the neck from teer interms of we're mulving an aging science. And there is one palmark of aging or two, which are calling a little bit, the others or is and there a hiraki. Yes, there's the degree of hiraki for example, a good a home mark on aging that we are

30:49 working on a lot is inflamation ok so this ideer the chronic inflamation a curse, dring aging and it is calls by a holseries of problems. But it self because part of the aging process, so it's a really mat adaptive. We all know about inflamation that you get if you cut yourself example, if you burn your skin, you will have a little bubble, it will be com red it will be com painful eventually the bubble is going to schrank you can have a little crust and eventually so this is all of this reactions of part is what we call inflamation this is AA repair prozess in the body.

31:32 At turns on as you h you abody you aquibulated damage for hosaries of reason. I'll think the example of ultraviolate light you go outside you get exposed to the son you can get a burn, but if you don't get a burn, the uve a radiation will in in doers DNA damage all of discreate damage and all abodies this is what drive the aging process and all abody respons to all of these insels by reparing it self VA inflamation. At some point gering, the Aging Prozess we're notable to repair as efficiently and then means releaed this leads to something chronic inflamation the problem is that the chronic inflamation normally resolve it sos one's you've have a burn and the cross is phone and off you're skin

32:20 looks like it you's to look at the beginning, it's going toly repair it and there's no trace of it in the case of chronic inflamation. Because the problem can have a be completely solved. It's stays there all the time and so there's really a lot of word contringed to understand this hole prosess that people call inflamaging and it's roll in the aging prosess because it turns out that the inflamation it soles becoms one of the problems on top of everything all so i was the a holaging prosess is very compicated.

32:53 We're still acording to what i've see in and really there's in understanding this prozess and there are amazing discoveriesto.com in the future, so this is what we're keeping working on. And could be that the wait los injections could decrease the inflamation the silent inflamation and little bit, so that's finish with a little bit of optimism. Name one of your research areas that will be particularly important for us piece.

33:27 Oh just this is really top. You're asking me to two's between my chilgin and I'm. Ok. I know I'm not to areas that I'm really exideed about is what we call this biomarkers of aging. We talk to about feen of have every and this discussion, there's right now is in explosion. In the study of all these biomarkers of agings or going things that are in you're blood that you can detect that change draging the aging prozess and hope for the that change. If you're schon the are intervening he the with the dragor a lifestyle modification, i would predic that we think that next five years we will have the stuols of valible some them or valible clinicly right now you can buy some kids i would are you that they're not

34:16 really. For prime time in terms of a consumer market, if you don't you can by them, but in the next five here is i think we going to larne all lot about how to we assess have we all go to live in some way some what blind we all think we doing the best we can to try to stay healthy, but we don't really have an indication and so the stuhls are going to be key in the future not on you for you and i to deside ok and i doing the right think but also. To MC recomendations, we tell if we about the we're should go on this died or this died.

34:51 It is so that he this the like leo is that many of this recomendations i're going to be hiley and divitual so this is what we goed personalies or procision medicine and that the tools are going to allowers what is working for you know what is working for me and what is working for brian johnson we all heard about brian johnson and what he is string to do.

35:11 Internes of optimizing is hef and what he's doing is working very well for brian johnson, but there's a good wrecking mission that and my not the working for you, but the ls because he is brian johnson so there is a really an need to develop this individualized tools to allar you to assess your hef and to and to modifieed acording lea, so that's one aria them really exideed about I'm. We do study the roll of information and in the roll of the immunsystem in aging, there is growing evidence that the immunsystem is key in the aging Prozess. We are learning how to recking nice to signs of aging and that system and one of the beauty of the immunsystem is that we can study it readily simply by

35:58 drying blood out of you're arm, we can get all of the blood sales we can study it am in the Lob. We can't botify them and reinfues them and there's have it in's right now emerging that the immune system the peers to be dominant in terms of it's roll in aging, there two argans that a peer to be ridi critical, it's the brain and the immune system and the reason for this is probibity because they are distributed argance so we have immune soles in the every tissue of abody. The brained it self coordinates everything so this is the two organs that you what a keep healthy as you h and this we're walking on that we're cride exoded because it means it is one of the central organs and the holaging process and i expect also in this aria and

36:43 then exeou yars a lot of events is a novel medicance thatwill.com all away. Thank you so much eric for your time and your valuable insights. It's a youge amount of informations for our really happy viewers and listeners and three months at the latest at will the time for the next update thank you. Right i pleasure go to see you.

37:09 Go to see you. Danke fürs Zuhören. Ich hoffe diese Folge hat dir gefallen. Weitere Informationen findest du wie immer. In den Show Notes. Wenn du etwas in dieser Folge gelernt hast und diesen Podcast unterstützen möchtest, würde ich mich über eine Bewertung freuen. Damit hilfst du mir und anderen Zuhörern, dass dieser Podcast und seine Inhalte leichter gefunden werden. Besuch mich auch auf meinen anderen Kanälen bei. Instagram, tik tok, Facebook oder You. Tube.

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