Ketamine & Cocaine: Ranking Drugs for Longevity (Part 1)

Can doing lines help you live longer? That depends on what you’re taking. In this three-part series, I’m ranking drugs based on their ties to longevity, starting with ketamine and cocaine. I tested ketamine on myself to study its impacts on the brain — here’s what we found.

Study Links:

Ketamine’s Effects on Epigenetic Age (medrxiv.org/content/10.1101/2024.09.10.2431325…?)

Extending Ketamine’s Therapeutic Window (science.org/doi/10.1126/science.abb6748)

Ibogaine Therapy for PTSD (nature.com/articles/s41591-023-02705-w)

Hosts:

Bryan Johnson: Blueprint Founder

Kate Tolo: Blueprint Co-Founder

Dr. Mike Mallin: Lead Physician for Bryan Johnson

Connect:

X: x.com/bryan_johnson

YouTube: youtube.com/@BryanJohnson

Instagram: instagram.com/bryanjohnson

TikTok: tiktok.com/@_bryan_johnson_

Chapters:

00:00 - Introduction

03:14 - Social Norms Around Drugs

08:59 - Psychedelics as Therapy: Overview

10:20 - Cocaine

17:15 - Fentanyl Dangers

23:27 - Ketamine: Brain Impacts + Longevity

41:29 - Measuring The Impacts of Psychedelics

47:51 - Longevity Rankings: Cocaine + Ketamine