Psilocybin, LSD & Marijuana: Ranking Drugs for Longevity (Part 2)

Should I try shrooms for science? In part two of three of our series investigating drugs for longevity, I’m putting psilocybin, LSD and DMT under the microscope - and revealing some pretty exciting research that connects psychedelics to longer lifespans. We’ll also talk about weed, and what the data says about marijuana for longevity.

Study Links:

Psilocybin for Cancer Patients (pmc.ncbi.nlm.nih.gov/articles/PMC5367557)

LSD: Longevity in Worms (biorxiv.org/content/10.1101/2025.06.16.659936v…)

Cannabis Use Disorder Increases Mortality Risk (jamanetwork.com/journals/jamanetworkopen/fulla…)

Marijuana Increases Epigenetic Aging (link.springer.com/article/10.1186/s13148-022-0…)

Marijuana’s Impacts on Sleep (pubmed.ncbi.nlm.nih.gov/24726015)

Improving Sleep with Medical Cannabis (pubmed.ncbi.nlm.nih.gov/36539991)

Hosts:

Bryan Johnson: Blueprint Founder

Kate Tolo: Blueprint Co-Founder

Dr. Mike Mallin: Lead Physician for Bryan Johnson

Connect:

X: x.com/bryan_johnson

YouTube: youtube.com/@BryanJohnson

Instagram: instagram.com/bryanjohnson

TikTok: tiktok.com/@_bryan_johnson_

Chapters:

00:00 - Introduction

01:52 - First Experiences With Drugs

05:42 - Psychedelics in Society

13:29 - Psilocybin, LSD & DMT

34:35 - Marijuana

50:53 - Longevity Rankings